Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Importance: This was a clinical study of total neoadjuvant therapy (TNT) for rectal cancer. Objective: To assess the use and outcomes of TNT in routine practice. Design, Setting, and Participants: This international, multicenter study was conducted at 61 centers across 21 countries and included cons...

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Autores principales: Alessandro Audisio, Chiara Gallio, Vaneja Velenik, Hélène Meillat, Erika Ruíz‐García, María Carmen Riesco Martínez, Javier Suárez Alecha, Gertjan Rasschaert, Carlos Carvalho, Violaine Randrian, Iva Kirac, Jorge Hernando, Mehmet Artaç, Juan Manuel O’Connor, Ithai Waldhorn, Pètra M. Braam, Ali Shamseddine, Roberto Moretto, Carolina de la Pinta, Francesca De Felice, Audrius Dulskas, D. Páez López-Bravo, Alexander Vanden Bulcke, Felix Bock, Amélie Deleporte, Marc Van den Eynde, Karen Geboes, Mauro Loi, Marco Messina, Constance Houlzé-Laroye, Alberto Puccini, Alessandro Pastorino, Demetris Papamichael, Michele Fiore, Daniel Sur, Michal Eid, Claire Antoun, Massimiliano Salati, Ingrid Garajová, Matas Jakubauskas, Jiří Tomášek, Cidália Pinto, Jérôme Schwingel, Federica Morano, Richard Adams, Alexandre Dermine, Amélie Chau, Ahsan Javed, Michele Ghidini, Francesco Fiorica, Paola Montenegro, Angelica Petrillo, Gaya Spolverato, N. Mulet Margalef, Marie Diaz, Chiara Baratelli, Francesco Puleo, Athanasios Karampeazis, Fatma Sert, Quentin Gilliaux, Alfonso De Stefano, Gabriel Liberale, Luigi Moretti, Philippe Martinive, Vaiva Deltuvaite Thomas, Vincent S. Staggs, Everardo D. Saad, Jean-Luc Van Laethem, Francesco Sclafani, Nada Benhima, Irene Assaf, Gianluca Ricco, Roberta Fazio, Fatima-Zahra Abbassi, Giacomo Bregni, Ana Veron, María Gómez Galdón, Maria Antonietta Bali, Ernestas Sileika, Edita Baltruškevičienė, Laura Miceviciute, Laudy Chehade, Annamaria Pessino, Chiara Pirrone, Greta Catani, Ana Fortuna, David Tougeron, Valentina Daprà, Michela Bartolini, María Alsina, Oğuzhan Yıldız, Maria E. Gallego, A.C. Virgili Manrique, M. Carmen Martínez, Josep Balart, Juan Carlos Pernas, Berta Martín-Cullell, Edith A. Fernández-Figueroa, Rogelio Cuervo-Campos, Antonio Moreno-Avendaño, Laura Galeani, Geneviève Van Ooteghem, Astrid De Cuyper, Christopthe Remue, R Bachmann, Daniel Léonard, Anca Dragean, Marie-Laure Castella, Paméla Baldin, Valeria Pavese, Beatrice Borelli, Elvira Rampello, Carlos Orlando Salsaña Reyes, Jennifer Aoun, Mariana Figueiredo, Martina Manni, Christos Cortas, Martina Benincasa, Marius Kryžauskas, Tomas Poškus, Carlo Messina, Nuno Couto, Ana Clara, Catarina Freitas, Joaquim Gago, G. Atalaia, S Soares Brandao, José Azevedo, Laura M. Fernández, Pedro Vieira, Hugo Domingos, Oriol Parés, Miguel Borges, Bernd Frerker, Francesco Celotto, Eva Pape, Gabriëlle H. van Ramshorst, Jhanzeb Ihsan, Victoria Shallcross, Shakil Ahmed, José María Fernández Cebrián, Ana Ferrer‐Gomez, E. Canales Lachén, Raquel García Latorre, Íñigo Martínez Delfrade, Beatriz Peñas García, M. Martín, B. Frutos, B.I. Morón, Reyes Ferreiro, Sofía Parejo, Juan Carlos García‐Ruiz, Pedro Abadía, Javier Díe Trill, Elena Mendía, Juan Ocaña Jiménez, E Tobaruela, Araceli Ballestero Pérez, Gloria M. Rodriguez, S. Sancho, André D’Hoore, Albert Wolthuis, Gabriele Bislenghi, Karin Haustermans, Sabine Tejpar, Filip Van Herpe, Jeroen Dekervel, Eric Van Cutsem, Raphaëla C. Dresen, Xavier Sagaert, Gert De Hertogh, Philippe Leclercq, Lynn Debrun, M. Amin Dalia, Andrea Modrego, Guillaume Piessen
Formato: Artículo
Lenguaje:inglés
Publicado: 2025
Materias:
Medicine
Neoadjuvant therapy
Colorectal cancer
Oncology
MEDLINE
Internal medicine
Cancer
Breast cancer
Political science
Law
Adenocarcinoma pathology
Adenocarcinoma therapy
Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Leucovorin therapeutic use
Female
Fluorouracil administration & dosage
Fluorouracil therapeutic use
Humans
Male
Middle Aged
Neoplasm Staging
Rectal Neoplasms drug therapy
Rectal Neoplasms mortality
Rectal Neoplasms pathology
Rectal Neoplasms therapy
Treatment Outcome
Neoadjuvant Therapy methods
Chemoradiotherapy
Health Sciences Medicine Oncology Colorectal Cancer Surgical Treatments
Health Sciences Medicine Surgery Colorectal and Anal Carcinomas
Health Sciences Medicine Pulmonary and Respiratory Medicine Prostate Cancer Diagnosis and Treatment
Acceso en línea:Ver en el sistema de origen
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