Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer
Importance: This was a clinical study of total neoadjuvant therapy (TNT) for rectal cancer. Objective: To assess the use and outcomes of TNT in routine practice. Design, Setting, and Participants: This international, multicenter study was conducted at 61 centers across 21 countries and included cons...
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2025
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| author | Alessandro Audisio Chiara Gallio Vaneja Velenik Hélène Meillat Erika Ruíz‐García María Carmen Riesco Martínez Javier Suárez Alecha Gertjan Rasschaert Carlos Carvalho Violaine Randrian Iva Kirac Jorge Hernando Mehmet Artaç Juan Manuel O’Connor Ithai Waldhorn Pètra M. Braam Ali Shamseddine Roberto Moretto Carolina de la Pinta Francesca De Felice Audrius Dulskas D. Páez López-Bravo Alexander Vanden Bulcke Felix Bock Amélie Deleporte Marc Van den Eynde Karen Geboes Mauro Loi Marco Messina Constance Houlzé-Laroye Alberto Puccini Alessandro Pastorino Demetris Papamichael Michele Fiore Daniel Sur Michal Eid Claire Antoun Massimiliano Salati Ingrid Garajová Matas Jakubauskas Jiří Tomášek Cidália Pinto Jérôme Schwingel Federica Morano Richard Adams Alexandre Dermine Amélie Chau Ahsan Javed Michele Ghidini Francesco Fiorica Paola Montenegro Angelica Petrillo Gaya Spolverato N. Mulet Margalef Marie Diaz Chiara Baratelli Francesco Puleo Athanasios Karampeazis Fatma Sert Quentin Gilliaux Alfonso De Stefano Gabriel Liberale Luigi Moretti Philippe Martinive Vaiva Deltuvaite Thomas Vincent S. Staggs Everardo D. Saad Jean-Luc Van Laethem Francesco Sclafani Nada Benhima Irene Assaf Gianluca Ricco Roberta Fazio Fatima-Zahra Abbassi Giacomo Bregni Ana Veron María Gómez Galdón Maria Antonietta Bali Ernestas Sileika Edita Baltruškevičienė Laura Miceviciute Laudy Chehade Annamaria Pessino Chiara Pirrone Greta Catani Ana Fortuna David Tougeron Valentina Daprà Michela Bartolini María Alsina Oğuzhan Yıldız Maria E. Gallego A.C. Virgili Manrique M. Carmen Martínez Josep Balart Juan Carlos Pernas Berta Martín-Cullell Edith A. Fernández-Figueroa Rogelio Cuervo-Campos Antonio Moreno-Avendaño Laura Galeani Geneviève Van Ooteghem Astrid De Cuyper Christopthe Remue R Bachmann Daniel Léonard Anca Dragean Marie-Laure Castella Paméla Baldin Valeria Pavese Beatrice Borelli Elvira Rampello Carlos Orlando Salsaña Reyes Jennifer Aoun Mariana Figueiredo Martina Manni Christos Cortas Martina Benincasa Marius Kryžauskas Tomas Poškus Carlo Messina Nuno Couto Ana Clara Catarina Freitas Joaquim Gago G. Atalaia S Soares Brandao José Azevedo Laura M. Fernández Pedro Vieira Hugo Domingos Oriol Parés Miguel Borges Bernd Frerker Francesco Celotto Eva Pape Gabriëlle H. van Ramshorst Jhanzeb Ihsan Victoria Shallcross Shakil Ahmed José María Fernández Cebrián Ana Ferrer‐Gomez E. Canales Lachén Raquel García Latorre Íñigo Martínez Delfrade Beatriz Peñas García M. Martín B. Frutos B.I. Morón Reyes Ferreiro Sofía Parejo Juan Carlos García‐Ruiz Pedro Abadía Javier Díe Trill Elena Mendía Juan Ocaña Jiménez E Tobaruela Araceli Ballestero Pérez Gloria M. Rodriguez S. Sancho André D’Hoore Albert Wolthuis Gabriele Bislenghi Karin Haustermans Sabine Tejpar Filip Van Herpe Jeroen Dekervel Eric Van Cutsem Raphaëla C. Dresen Xavier Sagaert Gert De Hertogh Philippe Leclercq Lynn Debrun M. Amin Dalia Andrea Modrego Guillaume Piessen |
| author_browse | A.C. Virgili Manrique Ahsan Javed Albert Wolthuis Alberto Puccini Alessandro Audisio Alessandro Pastorino Alexander Vanden Bulcke Alexandre Dermine Alfonso De Stefano Ali Shamseddine Amélie Chau Amélie Deleporte Ana Clara Ana Ferrer‐Gomez Ana Fortuna Ana Veron Anca Dragean Andrea Modrego André D’Hoore Angelica Petrillo Annamaria Pessino Antonio Moreno-Avendaño Araceli Ballestero Pérez Astrid De Cuyper Athanasios Karampeazis Audrius Dulskas B. Frutos B.I. Morón Beatrice Borelli Beatriz Peñas García Bernd Frerker Berta Martín-Cullell Carlo Messina Carlos Carvalho Carlos Orlando Salsaña Reyes Carolina de la Pinta Catarina Freitas Chiara Baratelli Chiara Gallio Chiara Pirrone Christopthe Remue Christos Cortas Cidália Pinto Claire Antoun Constance Houlzé-Laroye D. Páez López-Bravo Daniel Léonard Daniel Sur David Tougeron Demetris Papamichael E Tobaruela E. Canales Lachén Edita Baltruškevičienė Edith A. Fernández-Figueroa Elena Mendía Elvira Rampello Eric Van Cutsem Erika Ruíz‐García Ernestas Sileika Eva Pape Everardo D. Saad Fatima-Zahra Abbassi Fatma Sert Federica Morano Felix Bock Filip Van Herpe Francesca De Felice Francesco Celotto Francesco Fiorica Francesco Puleo Francesco Sclafani G. Atalaia Gabriel Liberale Gabriele Bislenghi Gabriëlle H. van Ramshorst Gaya Spolverato Geneviève Van Ooteghem Gert De Hertogh Gertjan Rasschaert Giacomo Bregni Gianluca Ricco Gloria M. Rodriguez Greta Catani Guillaume Piessen Hugo Domingos Hélène Meillat Ingrid Garajová Irene Assaf Ithai Waldhorn Iva Kirac Javier Díe Trill Javier Suárez Alecha Jean-Luc Van Laethem Jennifer Aoun Jeroen Dekervel Jhanzeb Ihsan Jiří Tomášek Joaquim Gago Jorge Hernando Josep Balart José Azevedo José María Fernández Cebrián Juan Carlos García‐Ruiz Juan Carlos Pernas Juan Manuel O’Connor Juan Ocaña Jiménez Jérôme Schwingel Karen Geboes Karin Haustermans Laudy Chehade Laura Galeani Laura M. Fernández Laura Miceviciute Luigi Moretti Lynn Debrun M. Amin Dalia M. Carmen Martínez M. Martín Marc Van den Eynde Marco Messina Maria Antonietta Bali Maria E. Gallego Mariana Figueiredo Marie Diaz Marie-Laure Castella Marius Kryžauskas Martina Benincasa Martina Manni María Alsina María Carmen Riesco Martínez María Gómez Galdón Massimiliano Salati Matas Jakubauskas Mauro Loi Mehmet Artaç Michal Eid Michela Bartolini Michele Fiore Michele Ghidini Miguel Borges N. Mulet Margalef Nada Benhima Nuno Couto Oriol Parés Oğuzhan Yıldız Paméla Baldin Paola Montenegro Pedro Abadía Pedro Vieira Philippe Leclercq Philippe Martinive Pètra M. Braam Quentin Gilliaux R Bachmann Raphaëla C. Dresen Raquel García Latorre Reyes Ferreiro Richard Adams Roberta Fazio Roberto Moretto Rogelio Cuervo-Campos S Soares Brandao S. Sancho Sabine Tejpar Shakil Ahmed Sofía Parejo Tomas Poškus Vaiva Deltuvaite Thomas Valentina Daprà Valeria Pavese Vaneja Velenik Victoria Shallcross Vincent S. Staggs Violaine Randrian Xavier Sagaert Íñigo Martínez Delfrade |
| author_facet | Alessandro Audisio Chiara Gallio Vaneja Velenik Hélène Meillat Erika Ruíz‐García María Carmen Riesco Martínez Javier Suárez Alecha Gertjan Rasschaert Carlos Carvalho Violaine Randrian Iva Kirac Jorge Hernando Mehmet Artaç Juan Manuel O’Connor Ithai Waldhorn Pètra M. Braam Ali Shamseddine Roberto Moretto Carolina de la Pinta Francesca De Felice Audrius Dulskas D. Páez López-Bravo Alexander Vanden Bulcke Felix Bock Amélie Deleporte Marc Van den Eynde Karen Geboes Mauro Loi Marco Messina Constance Houlzé-Laroye Alberto Puccini Alessandro Pastorino Demetris Papamichael Michele Fiore Daniel Sur Michal Eid Claire Antoun Massimiliano Salati Ingrid Garajová Matas Jakubauskas Jiří Tomášek Cidália Pinto Jérôme Schwingel Federica Morano Richard Adams Alexandre Dermine Amélie Chau Ahsan Javed Michele Ghidini Francesco Fiorica Paola Montenegro Angelica Petrillo Gaya Spolverato N. Mulet Margalef Marie Diaz Chiara Baratelli Francesco Puleo Athanasios Karampeazis Fatma Sert Quentin Gilliaux Alfonso De Stefano Gabriel Liberale Luigi Moretti Philippe Martinive Vaiva Deltuvaite Thomas Vincent S. Staggs Everardo D. Saad Jean-Luc Van Laethem Francesco Sclafani Nada Benhima Irene Assaf Gianluca Ricco Roberta Fazio Fatima-Zahra Abbassi Giacomo Bregni Ana Veron María Gómez Galdón Maria Antonietta Bali Ernestas Sileika Edita Baltruškevičienė Laura Miceviciute Laudy Chehade Annamaria Pessino Chiara Pirrone Greta Catani Ana Fortuna David Tougeron Valentina Daprà Michela Bartolini María Alsina Oğuzhan Yıldız Maria E. Gallego A.C. Virgili Manrique M. Carmen Martínez Josep Balart Juan Carlos Pernas Berta Martín-Cullell Edith A. Fernández-Figueroa Rogelio Cuervo-Campos Antonio Moreno-Avendaño Laura Galeani Geneviève Van Ooteghem Astrid De Cuyper Christopthe Remue R Bachmann Daniel Léonard Anca Dragean Marie-Laure Castella Paméla Baldin Valeria Pavese Beatrice Borelli Elvira Rampello Carlos Orlando Salsaña Reyes Jennifer Aoun Mariana Figueiredo Martina Manni Christos Cortas Martina Benincasa Marius Kryžauskas Tomas Poškus Carlo Messina Nuno Couto Ana Clara Catarina Freitas Joaquim Gago G. Atalaia S Soares Brandao José Azevedo Laura M. Fernández Pedro Vieira Hugo Domingos Oriol Parés Miguel Borges Bernd Frerker Francesco Celotto Eva Pape Gabriëlle H. van Ramshorst Jhanzeb Ihsan Victoria Shallcross Shakil Ahmed José María Fernández Cebrián Ana Ferrer‐Gomez E. Canales Lachén Raquel García Latorre Íñigo Martínez Delfrade Beatriz Peñas García M. Martín B. Frutos B.I. Morón Reyes Ferreiro Sofía Parejo Juan Carlos García‐Ruiz Pedro Abadía Javier Díe Trill Elena Mendía Juan Ocaña Jiménez E Tobaruela Araceli Ballestero Pérez Gloria M. Rodriguez S. Sancho André D’Hoore Albert Wolthuis Gabriele Bislenghi Karin Haustermans Sabine Tejpar Filip Van Herpe Jeroen Dekervel Eric Van Cutsem Raphaëla C. Dresen Xavier Sagaert Gert De Hertogh Philippe Leclercq Lynn Debrun M. Amin Dalia Andrea Modrego Guillaume Piessen |
| author_sort | Alessandro Audisio |
| collection | Producción científica |
| description | Importance: This was a clinical study of total neoadjuvant therapy (TNT) for rectal cancer. Objective: To assess the use and outcomes of TNT in routine practice. Design, Setting, and Participants: This international, multicenter study was conducted at 61 centers across 21 countries and included consecutive patients treated off trial with TNT for stage II/III rectal adenocarcinoma from September 2012 to December 2023. Data were analyzed between August and October 2024. Exposure: TNT, defined as the delivery of radiotherapy and nonradiosensitizing chemotherapy before surgery or watch and wait. Main Outcomes and Measures: The primary outcome was type of TNT administered. Secondary outcomes were patient characteristics, treatment adherence, safety, and efficacy overall and by type of TNT in the entire population and after propensity vector matching. Results: A total of 1585 patients (588 female [37.1%]; median [IQR] age, 61 [53-68] years) were included, 1260 (79.5%) of whom had 1 or more high-risk features (eg, cT4, cN2, extramural venous invasion, threatened/involved mesorectal fascia, and lateropelvic lymphadenopathy). Patients were treated with the PRODIGE 23-like regimen (FOLFIRINOX/FOLFOXIRI followed by long-course chemoradiotherapy) (271 [17.7%]), RAPIDO-like regimen (short-course radiotherapy followed by consolidation FOLFOX/CAPOX) (529 [33.4%]), OPRA induction-like (induction FOLFOX/CAPOX followed by long-course chemoradiotherapy) (190 [12.0%]), OPRA consolidation-like (long-course chemoradiotherapy followed by consolidation FOLFOX/CAPOX) (257 [16.2%]), and other regimens (360 [22.7%]). After TNT, 192 (12.1%) underwent watch and wait, and 30 (1.9%) underwent local excision. Pathological or clinical complete response was reported in 23.2% of cases. At treatment failure, 8.5% was local and 16.4% was distant progression. Three-year event-free survival (EFS) was 68% (95% CI, 64%-71%), and 5-year overall survival (OS) was 79% (95% CI, 75%-83%). In the overall population, patients treated with the PRODIGE 23-like regimen were most likely to have serious adverse events (61 [23.5%]) but had better local control and survival outcomes than those treated with the RAPIDO-like (EFS: hazard ratio [HR], 0.68; 95% CI, 0.49-0.95; P = .03; OS: HR, 0.51; 95% CI, 0.27-0.97; P = .04), OPRA induction-like (EFS: HR, 0.66; 95% CI, 0.44-0.98; P = .04; OS: HR, 0.35; 95% CI, 0.18-0.70; P = .003), and OPRA consolidation-like (EFS: HR, 0.64; 95% CI, 0.44-0.93; P = .02; OS: HR, 0.50; 95% CI, 0.25-1.00; P = .05) regimens. In the matched population (928 patients [58.5%]), no differences in survival outcomes were observed between the TNT regimens. Conclusions and Relevance: The findings of this case series study show substantial variation in the choice of the TNT regimen and were overall aligned with those reported in clinical trials, suggesting the efficacy of TNT in a clinical setting regardless of the specific regimen. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1169 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/11692026-10-30T16:15:18ZTotal Neoadjuvant Therapy for Locally Advanced Rectal CancerAlessandro AudisioChiara GallioVaneja VelenikHélène MeillatErika Ruíz‐GarcíaMaría Carmen Riesco MartínezJavier Suárez AlechaGertjan RasschaertCarlos CarvalhoViolaine RandrianIva KiracJorge HernandoMehmet ArtaçJuan Manuel O’ConnorIthai WaldhornPètra M. BraamAli ShamseddineRoberto MorettoCarolina de la PintaFrancesca De FeliceAudrius DulskasD. Páez López-BravoAlexander Vanden BulckeFelix BockAmélie DeleporteMarc Van den EyndeKaren GeboesMauro LoiMarco MessinaConstance Houlzé-LaroyeAlberto PucciniAlessandro PastorinoDemetris PapamichaelMichele FioreDaniel SurMichal EidClaire AntounMassimiliano SalatiIngrid GarajováMatas JakubauskasJiří TomášekCidália PintoJérôme SchwingelFederica MoranoRichard AdamsAlexandre DermineAmélie ChauAhsan JavedMichele GhidiniFrancesco FioricaPaola MontenegroAngelica PetrilloGaya SpolveratoN. Mulet MargalefMarie DiazChiara BaratelliFrancesco PuleoAthanasios KarampeazisFatma SertQuentin GilliauxAlfonso De StefanoGabriel LiberaleLuigi MorettiPhilippe MartiniveVaiva Deltuvaite ThomasVincent S. StaggsEverardo D. SaadJean-Luc Van LaethemFrancesco SclafaniNada BenhimaIrene AssafGianluca RiccoRoberta FazioFatima-Zahra AbbassiGiacomo BregniAna VeronMaría Gómez GaldónMaria Antonietta BaliErnestas SileikaEdita BaltruškevičienėLaura MiceviciuteLaudy ChehadeAnnamaria PessinoChiara PirroneGreta CataniAna FortunaDavid TougeronValentina DapràMichela BartoliniMaría AlsinaOğuzhan YıldızMaria E. GallegoA.C. Virgili ManriqueM. Carmen MartínezJosep BalartJuan Carlos PernasBerta Martín-CullellEdith A. Fernández-FigueroaRogelio Cuervo-CamposAntonio Moreno-AvendañoLaura GaleaniGeneviève Van OoteghemAstrid De CuyperChristopthe RemueR BachmannDaniel LéonardAnca DrageanMarie-Laure CastellaPaméla BaldinValeria PaveseBeatrice BorelliElvira RampelloCarlos Orlando Salsaña ReyesJennifer AounMariana FigueiredoMartina ManniChristos CortasMartina BenincasaMarius KryžauskasTomas PoškusCarlo MessinaNuno CoutoAna ClaraCatarina FreitasJoaquim GagoG. AtalaiaS Soares BrandaoJosé AzevedoLaura M. FernándezPedro VieiraHugo DomingosOriol ParésMiguel BorgesBernd FrerkerFrancesco CelottoEva PapeGabriëlle H. van RamshorstJhanzeb IhsanVictoria ShallcrossShakil AhmedJosé María Fernández CebriánAna Ferrer‐GomezE. Canales LachénRaquel García LatorreÍñigo Martínez DelfradeBeatriz Peñas GarcíaM. MartínB. FrutosB.I. MorónReyes FerreiroSofía ParejoJuan Carlos García‐RuizPedro AbadíaJavier Díe TrillElena MendíaJuan Ocaña JiménezE TobaruelaAraceli Ballestero PérezGloria M. RodriguezS. SanchoAndré D’HooreAlbert WolthuisGabriele BislenghiKarin HaustermansSabine TejparFilip Van HerpeJeroen DekervelEric Van CutsemRaphaëla C. DresenXavier SagaertGert De HertoghPhilippe LeclercqLynn DebrunM. Amin DaliaAndrea ModregoGuillaume PiessenMedicineNeoadjuvant therapyColorectal cancerOncologyMEDLINEInternal medicineCancerBreast cancerPolitical scienceLawMedicineNeoadjuvant therapyColorectal cancerOncologyMEDLINEInternal medicineCancerBreast cancerAdenocarcinoma pathologyAdenocarcinoma pathologyAdenocarcinoma pathologyAdenocarcinoma therapyAdenocarcinoma therapyAdenocarcinoma therapyAgedAgedAgedAntineoplastic Combined Chemotherapy Protocols therapeutic useAntineoplastic Combined Chemotherapy Protocols therapeutic useAntineoplastic Combined Chemotherapy Protocols therapeutic useLeucovorin therapeutic useLeucovorin therapeutic useLeucovorin therapeutic useFemaleFemaleFemaleFluorouracil administration & dosageFluorouracil administration & dosageFluorouracil administration & dosageFluorouracil therapeutic useFluorouracil therapeutic useFluorouracil therapeutic useHumansHumansHumansMaleMaleMaleMiddle AgedMiddle AgedMiddle AgedNeoplasm StagingNeoplasm StagingNeoplasm StagingRectal Neoplasms drug therapyRectal Neoplasms drug therapyRectal Neoplasms drug therapyRectal Neoplasms mortalityRectal Neoplasms mortalityRectal Neoplasms mortalityRectal Neoplasms pathologyRectal Neoplasms pathologyRectal Neoplasms pathologyRectal Neoplasms therapyRectal Neoplasms therapyRectal Neoplasms therapyTreatment OutcomeTreatment OutcomeTreatment OutcomeNeoadjuvant Therapy methodsNeoadjuvant Therapy methodsNeoadjuvant Therapy methodsChemoradiotherapyChemoradiotherapyChemoradiotherapyHealth Sciences Medicine Oncology Colorectal Cancer Surgical TreatmentsHealth Sciences Medicine Surgery Colorectal and Anal CarcinomasHealth Sciences Medicine Pulmonary and Respiratory Medicine Prostate Cancer Diagnosis and TreatmentImportance: This was a clinical study of total neoadjuvant therapy (TNT) for rectal cancer. Objective: To assess the use and outcomes of TNT in routine practice. Design, Setting, and Participants: This international, multicenter study was conducted at 61 centers across 21 countries and included consecutive patients treated off trial with TNT for stage II/III rectal adenocarcinoma from September 2012 to December 2023. Data were analyzed between August and October 2024. Exposure: TNT, defined as the delivery of radiotherapy and nonradiosensitizing chemotherapy before surgery or watch and wait. Main Outcomes and Measures: The primary outcome was type of TNT administered. Secondary outcomes were patient characteristics, treatment adherence, safety, and efficacy overall and by type of TNT in the entire population and after propensity vector matching. Results: A total of 1585 patients (588 female [37.1%]; median [IQR] age, 61 [53-68] years) were included, 1260 (79.5%) of whom had 1 or more high-risk features (eg, cT4, cN2, extramural venous invasion, threatened/involved mesorectal fascia, and lateropelvic lymphadenopathy). Patients were treated with the PRODIGE 23-like regimen (FOLFIRINOX/FOLFOXIRI followed by long-course chemoradiotherapy) (271 [17.7%]), RAPIDO-like regimen (short-course radiotherapy followed by consolidation FOLFOX/CAPOX) (529 [33.4%]), OPRA induction-like (induction FOLFOX/CAPOX followed by long-course chemoradiotherapy) (190 [12.0%]), OPRA consolidation-like (long-course chemoradiotherapy followed by consolidation FOLFOX/CAPOX) (257 [16.2%]), and other regimens (360 [22.7%]). After TNT, 192 (12.1%) underwent watch and wait, and 30 (1.9%) underwent local excision. Pathological or clinical complete response was reported in 23.2% of cases. At treatment failure, 8.5% was local and 16.4% was distant progression. Three-year event-free survival (EFS) was 68% (95% CI, 64%-71%), and 5-year overall survival (OS) was 79% (95% CI, 75%-83%). In the overall population, patients treated with the PRODIGE 23-like regimen were most likely to have serious adverse events (61 [23.5%]) but had better local control and survival outcomes than those treated with the RAPIDO-like (EFS: hazard ratio [HR], 0.68; 95% CI, 0.49-0.95; P = .03; OS: HR, 0.51; 95% CI, 0.27-0.97; P = .04), OPRA induction-like (EFS: HR, 0.66; 95% CI, 0.44-0.98; P = .04; OS: HR, 0.35; 95% CI, 0.18-0.70; P = .003), and OPRA consolidation-like (EFS: HR, 0.64; 95% CI, 0.44-0.93; P = .02; OS: HR, 0.50; 95% CI, 0.25-1.00; P = .05) regimens. In the matched population (928 patients [58.5%]), no differences in survival outcomes were observed between the TNT regimens. Conclusions and Relevance: The findings of this case series study show substantial variation in the choice of the TNT regimen and were overall aligned with those reported in clinical trials, suggesting the efficacy of TNT in a clinical setting regardless of the specific regimen.Articlehttps://pubmed.ncbi.nlm.nih.gov/40638097http://hdl.handle.net/2078.1/30377810.1001/jamaoncol.2025.2026https://hdl.handle.net/20.500.15037/1169W4412161458enJAMA Oncology2374-24372374-24452025-07-102026-06-13T09:48:32Z2026-06-13T09:48:32Z |
| spellingShingle | Medicine Neoadjuvant therapy Colorectal cancer Oncology MEDLINE Internal medicine Cancer Breast cancer Political science Law Medicine Neoadjuvant therapy Colorectal cancer Oncology MEDLINE Internal medicine Cancer Breast cancer Adenocarcinoma pathology Adenocarcinoma pathology Adenocarcinoma pathology Adenocarcinoma therapy Adenocarcinoma therapy Adenocarcinoma therapy Aged Aged Aged Antineoplastic Combined Chemotherapy Protocols therapeutic use Antineoplastic Combined Chemotherapy Protocols therapeutic use Antineoplastic Combined Chemotherapy Protocols therapeutic use Leucovorin therapeutic use Leucovorin therapeutic use Leucovorin therapeutic use Female Female Female Fluorouracil administration & dosage Fluorouracil administration & dosage Fluorouracil administration & dosage Fluorouracil therapeutic use Fluorouracil therapeutic use Fluorouracil therapeutic use Humans Humans Humans Male Male Male Middle Aged Middle Aged Middle Aged Neoplasm Staging Neoplasm Staging Neoplasm Staging Rectal Neoplasms drug therapy Rectal Neoplasms drug therapy Rectal Neoplasms drug therapy Rectal Neoplasms mortality Rectal Neoplasms mortality Rectal Neoplasms mortality Rectal Neoplasms pathology Rectal Neoplasms pathology Rectal Neoplasms pathology Rectal Neoplasms therapy Rectal Neoplasms therapy Rectal Neoplasms therapy Treatment Outcome Treatment Outcome Treatment Outcome Neoadjuvant Therapy methods Neoadjuvant Therapy methods Neoadjuvant Therapy methods Chemoradiotherapy Chemoradiotherapy Chemoradiotherapy Health Sciences Medicine Oncology Colorectal Cancer Surgical Treatments Health Sciences Medicine Surgery Colorectal and Anal Carcinomas Health Sciences Medicine Pulmonary and Respiratory Medicine Prostate Cancer Diagnosis and Treatment Alessandro Audisio Chiara Gallio Vaneja Velenik Hélène Meillat Erika Ruíz‐García María Carmen Riesco Martínez Javier Suárez Alecha Gertjan Rasschaert Carlos Carvalho Violaine Randrian Iva Kirac Jorge Hernando Mehmet Artaç Juan Manuel O’Connor Ithai Waldhorn Pètra M. Braam Ali Shamseddine Roberto Moretto Carolina de la Pinta Francesca De Felice Audrius Dulskas D. Páez López-Bravo Alexander Vanden Bulcke Felix Bock Amélie Deleporte Marc Van den Eynde Karen Geboes Mauro Loi Marco Messina Constance Houlzé-Laroye Alberto Puccini Alessandro Pastorino Demetris Papamichael Michele Fiore Daniel Sur Michal Eid Claire Antoun Massimiliano Salati Ingrid Garajová Matas Jakubauskas Jiří Tomášek Cidália Pinto Jérôme Schwingel Federica Morano Richard Adams Alexandre Dermine Amélie Chau Ahsan Javed Michele Ghidini Francesco Fiorica Paola Montenegro Angelica Petrillo Gaya Spolverato N. Mulet Margalef Marie Diaz Chiara Baratelli Francesco Puleo Athanasios Karampeazis Fatma Sert Quentin Gilliaux Alfonso De Stefano Gabriel Liberale Luigi Moretti Philippe Martinive Vaiva Deltuvaite Thomas Vincent S. Staggs Everardo D. Saad Jean-Luc Van Laethem Francesco Sclafani Nada Benhima Irene Assaf Gianluca Ricco Roberta Fazio Fatima-Zahra Abbassi Giacomo Bregni Ana Veron María Gómez Galdón Maria Antonietta Bali Ernestas Sileika Edita Baltruškevičienė Laura Miceviciute Laudy Chehade Annamaria Pessino Chiara Pirrone Greta Catani Ana Fortuna David Tougeron Valentina Daprà Michela Bartolini María Alsina Oğuzhan Yıldız Maria E. Gallego A.C. Virgili Manrique M. Carmen Martínez Josep Balart Juan Carlos Pernas Berta Martín-Cullell Edith A. Fernández-Figueroa Rogelio Cuervo-Campos Antonio Moreno-Avendaño Laura Galeani Geneviève Van Ooteghem Astrid De Cuyper Christopthe Remue R Bachmann Daniel Léonard Anca Dragean Marie-Laure Castella Paméla Baldin Valeria Pavese Beatrice Borelli Elvira Rampello Carlos Orlando Salsaña Reyes Jennifer Aoun Mariana Figueiredo Martina Manni Christos Cortas Martina Benincasa Marius Kryžauskas Tomas Poškus Carlo Messina Nuno Couto Ana Clara Catarina Freitas Joaquim Gago G. Atalaia S Soares Brandao José Azevedo Laura M. Fernández Pedro Vieira Hugo Domingos Oriol Parés Miguel Borges Bernd Frerker Francesco Celotto Eva Pape Gabriëlle H. van Ramshorst Jhanzeb Ihsan Victoria Shallcross Shakil Ahmed José María Fernández Cebrián Ana Ferrer‐Gomez E. Canales Lachén Raquel García Latorre Íñigo Martínez Delfrade Beatriz Peñas García M. Martín B. Frutos B.I. Morón Reyes Ferreiro Sofía Parejo Juan Carlos García‐Ruiz Pedro Abadía Javier Díe Trill Elena Mendía Juan Ocaña Jiménez E Tobaruela Araceli Ballestero Pérez Gloria M. Rodriguez S. Sancho André D’Hoore Albert Wolthuis Gabriele Bislenghi Karin Haustermans Sabine Tejpar Filip Van Herpe Jeroen Dekervel Eric Van Cutsem Raphaëla C. Dresen Xavier Sagaert Gert De Hertogh Philippe Leclercq Lynn Debrun M. Amin Dalia Andrea Modrego Guillaume Piessen Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer |
| title | Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer |
| title_full | Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer |
| title_fullStr | Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer |
| title_full_unstemmed | Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer |
| title_short | Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer |
| title_sort | total neoadjuvant therapy for locally advanced rectal cancer |
| topic | Medicine Neoadjuvant therapy Colorectal cancer Oncology MEDLINE Internal medicine Cancer Breast cancer Political science Law Medicine Neoadjuvant therapy Colorectal cancer Oncology MEDLINE Internal medicine Cancer Breast cancer Adenocarcinoma pathology Adenocarcinoma pathology Adenocarcinoma pathology Adenocarcinoma therapy Adenocarcinoma therapy Adenocarcinoma therapy Aged Aged Aged Antineoplastic Combined Chemotherapy Protocols therapeutic use Antineoplastic Combined Chemotherapy Protocols therapeutic use Antineoplastic Combined Chemotherapy Protocols therapeutic use Leucovorin therapeutic use Leucovorin therapeutic use Leucovorin therapeutic use Female Female Female Fluorouracil administration & dosage Fluorouracil administration & dosage Fluorouracil administration & dosage Fluorouracil therapeutic use Fluorouracil therapeutic use Fluorouracil therapeutic use Humans Humans Humans Male Male Male Middle Aged Middle Aged Middle Aged Neoplasm Staging Neoplasm Staging Neoplasm Staging Rectal Neoplasms drug therapy Rectal Neoplasms drug therapy Rectal Neoplasms drug therapy Rectal Neoplasms mortality Rectal Neoplasms mortality Rectal Neoplasms mortality Rectal Neoplasms pathology Rectal Neoplasms pathology Rectal Neoplasms pathology Rectal Neoplasms therapy Rectal Neoplasms therapy Rectal Neoplasms therapy Treatment Outcome Treatment Outcome Treatment Outcome Neoadjuvant Therapy methods Neoadjuvant Therapy methods Neoadjuvant Therapy methods Chemoradiotherapy Chemoradiotherapy Chemoradiotherapy Health Sciences Medicine Oncology Colorectal Cancer Surgical Treatments Health Sciences Medicine Surgery Colorectal and Anal Carcinomas Health Sciences Medicine Pulmonary and Respiratory Medicine Prostate Cancer Diagnosis and Treatment |
| topic_facet | Medicine Neoadjuvant therapy Colorectal cancer Oncology MEDLINE Internal medicine Cancer Breast cancer Political science Law Medicine Neoadjuvant therapy Colorectal cancer Oncology MEDLINE Internal medicine Cancer Breast cancer Adenocarcinoma pathology Adenocarcinoma pathology Adenocarcinoma pathology Adenocarcinoma therapy Adenocarcinoma therapy Adenocarcinoma therapy Aged Aged Aged Antineoplastic Combined Chemotherapy Protocols therapeutic use Antineoplastic Combined Chemotherapy Protocols therapeutic use Antineoplastic Combined Chemotherapy Protocols therapeutic use Leucovorin therapeutic use Leucovorin therapeutic use Leucovorin therapeutic use Female Female Female Fluorouracil administration & dosage Fluorouracil administration & dosage Fluorouracil administration & dosage Fluorouracil therapeutic use Fluorouracil therapeutic use Fluorouracil therapeutic use Humans Humans Humans Male Male Male Middle Aged Middle Aged Middle Aged Neoplasm Staging Neoplasm Staging Neoplasm Staging Rectal Neoplasms drug therapy Rectal Neoplasms drug therapy Rectal Neoplasms drug therapy Rectal Neoplasms mortality Rectal Neoplasms mortality Rectal Neoplasms mortality Rectal Neoplasms pathology Rectal Neoplasms pathology Rectal Neoplasms pathology Rectal Neoplasms therapy Rectal Neoplasms therapy Rectal Neoplasms therapy Treatment Outcome Treatment Outcome Treatment Outcome Neoadjuvant Therapy methods Neoadjuvant Therapy methods Neoadjuvant Therapy methods Chemoradiotherapy Chemoradiotherapy Chemoradiotherapy Health Sciences Medicine Oncology Colorectal Cancer Surgical Treatments Health Sciences Medicine Surgery Colorectal and Anal Carcinomas Health Sciences Medicine Pulmonary and Respiratory Medicine Prostate Cancer Diagnosis and Treatment |
| url | https://pubmed.ncbi.nlm.nih.gov/40638097 http://hdl.handle.net/2078.1/303778 https://hdl.handle.net/20.500.15037/1169 |
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