Evidence-based clinical standard for the diagnosis and treatment of invasive lung aspergillosis in the patient with oncohematologic disease

Aspergillosis is a disease caused by the filamentous fungus Aspergillus spp. with a spectrum of clinical presentation that includes invasive and noninvasive forms. The invasive clinical presentation of aspergillosis most frequently affects people with compromised immune systems. In patients with onc...

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Autores principales: Jorge Alberto Cortés, Diego Andrés Rodríguez Lugo, Martha Carolina Valderrama-Ríos, Ricardo Rabagliati, Domênico Capone, Carlos Álvarez, Fabio Varón-Vega, Laura Cristina Nócua-Báez, Cándida Díaz‐Brochero, Leonardo Enciso-Olivera, Sonia Isabel Cuervo, Luis Thompson, Dora Corzo-León, Luis E. Cuéllar, Erika Paola Vergara, Fernando Riera, Patricia Cornejo‐Juárez, Rita Rojas, Beatriz L. Gómez, Adriana Marcela Celis Ramírez, José Luis Sandoval‐Gutiérrez, Mauricio Sarmiento, Diana Lorena Ochoa, Márcio Nucci
Formato: Artículo
Lenguaje:inglés
Publicado: 2025
Materias:
Aspergillosis
Context (archaeology)
Guideline
Intensive care medicine
Medicine
Disease
Immunology
Pathology
Biology
Paleontology
Antifungal Agents therapeutic use
Humans
Immunocompromised Host
Evidence-Based Medicine
Evidence-Based Medicine standards
Hematologic Neoplasms complications
Hematologic Neoplasms immunology
Invasive Pulmonary Aspergillosis diagnosis
Invasive Pulmonary Aspergillosis drug therapy
Invasive Pulmonary Aspergillosis immunology
Invasive Pulmonary Aspergillosis microbiology
Health Sciences Medicine Infectious Diseases Antifungal resistance and susceptibility
Health Sciences Medicine Epidemiology Fungal Infections and Studies
Health Sciences Veterinary Small Animals Infectious Diseases and Mycology
Acceso en línea:Ver en el sistema de origen
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Sumario:Aspergillosis is a disease caused by the filamentous fungus Aspergillus spp. with a spectrum of clinical presentation that includes invasive and noninvasive forms. The invasive clinical presentation of aspergillosis most frequently affects people with compromised immune systems. In patients with oncohematologic pathology, invasive lung aspergillosis is a significant opportunistic mycosis, because it occurs frequently and has a major impact on morbidity, mortality, and high costs. The global problem of antimicrobial resistance, to which improper use of antifungals contributes, has put Aspergilus spp. in the spotlight, so it is important to generate guidelines for guidance in the proper use of antifungals in the management of invasive lung aspergillosis, to obtain better clinical outcomes and promote rational use of antifungals. This guideline contains recommendations for diagnosing and treating invasive lung aspergillosis in patients with oncohematologic disease, based on evidence and defined through a participatory process of expert consensus, for the Latin American context.

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