Cerebral hemodynamic changes at high altitude in adults: a systematic review and meta-analysis of transcranial Doppler and duplex ultrasound studies
In this first global meta-analysis of ultrasound-based cerebral hemodynamics at ≥1,500 m, we show that altitude exposure is associated with lower cerebral blood flow velocity, volumetric flow, arterial diameter, and oxygen saturation in healthy adults. Native status, age, and altitude level partly e...
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| Formato: | Artículo de revisión |
| Lenguaje: | inglés |
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2026
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| _version_ | 1881700513951514624 |
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| author | Jean Pierre Zila-Velasque Pamela Grados‐Espinoza Sebastian Abanto-Urbano Mely Olarte-Durand Martha Isabel Vilca-Salas Paula Moran-Ballon Carlos Quispe‐Vicuña Victor Velásquez‐Rimachi Joel M. Sequeiros Kateriny Margot Regalado-Rodríguez Patrick E. Zila-Velasque Sthefano E. Zila-Velasque Sheidy Clemente-Tueros Fernando Terry Carlos Alva‐Díaz |
| author_browse | Carlos Alva‐Díaz Carlos Quispe‐Vicuña Fernando Terry Jean Pierre Zila-Velasque Joel M. Sequeiros Kateriny Margot Regalado-Rodríguez Martha Isabel Vilca-Salas Mely Olarte-Durand Pamela Grados‐Espinoza Patrick E. Zila-Velasque Paula Moran-Ballon Sebastian Abanto-Urbano Sheidy Clemente-Tueros Sthefano E. Zila-Velasque Victor Velásquez‐Rimachi |
| author_facet | Jean Pierre Zila-Velasque Pamela Grados‐Espinoza Sebastian Abanto-Urbano Mely Olarte-Durand Martha Isabel Vilca-Salas Paula Moran-Ballon Carlos Quispe‐Vicuña Victor Velásquez‐Rimachi Joel M. Sequeiros Kateriny Margot Regalado-Rodríguez Patrick E. Zila-Velasque Sthefano E. Zila-Velasque Sheidy Clemente-Tueros Fernando Terry Carlos Alva‐Díaz |
| author_sort | Jean Pierre Zila-Velasque |
| collection | Producción científica |
| description | In this first global meta-analysis of ultrasound-based cerebral hemodynamics at ≥1,500 m, we show that altitude exposure is associated with lower cerebral blood flow velocity, volumetric flow, arterial diameter, and oxygen saturation in healthy adults. Native status, age, and altitude level partly explain marked heterogeneity. These findings highlight distinct adaptive patterns between native and nonnative populations and underscore the need for standardized, longitudinal studies of brain perfusion at altitude. |
| format | Review |
| id | openalex:W7170093755 |
| institution | UPeU |
| language | English |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| record_format | dspace |
| spelling | openalex:W7170093755Cerebral hemodynamic changes at high altitude in adults: a systematic review and meta-analysis of transcranial Doppler and duplex ultrasound studiesJean Pierre Zila-VelasquePamela Grados‐EspinozaSebastian Abanto-UrbanoMely Olarte-DurandMartha Isabel Vilca-SalasPaula Moran-BallonCarlos Quispe‐VicuñaVictor Velásquez‐RimachiJoel M. SequeirosKateriny Margot Regalado-RodríguezPatrick E. Zila-VelasqueSthefano E. Zila-VelasqueSheidy Clemente-TuerosFernando TerryCarlos Alva‐Díazhigh altitudecerebral hemodynamicscerebral blood flow velocitycerebral blood flowcerebral oxygen saturationcerebral arteriesarterial diameterhigh-altitude adaptationcerebral perfusionHigh Altitude and HypoxiaSpaceflight effects on biologyThermoregulation and physiological responsesIn this first global meta-analysis of ultrasound-based cerebral hemodynamics at ≥1,500 m, we show that altitude exposure is associated with lower cerebral blood flow velocity, volumetric flow, arterial diameter, and oxygen saturation in healthy adults. Native status, age, and altitude level partly explain marked heterogeneity. These findings highlight distinct adaptive patterns between native and nonnative populations and underscore the need for standardized, longitudinal studies of brain perfusion at altitude.Reviewhttps://doi.org/10.1152/japplphysiol.00176.2026W7170093755enJournal of Applied Physiology0161-75671522-16018750-75872026-07-22 |
| spellingShingle | high altitude cerebral hemodynamics cerebral blood flow velocity cerebral blood flow cerebral oxygen saturation cerebral arteries arterial diameter high-altitude adaptation cerebral perfusion High Altitude and Hypoxia Spaceflight effects on biology Thermoregulation and physiological responses Jean Pierre Zila-Velasque Pamela Grados‐Espinoza Sebastian Abanto-Urbano Mely Olarte-Durand Martha Isabel Vilca-Salas Paula Moran-Ballon Carlos Quispe‐Vicuña Victor Velásquez‐Rimachi Joel M. Sequeiros Kateriny Margot Regalado-Rodríguez Patrick E. Zila-Velasque Sthefano E. Zila-Velasque Sheidy Clemente-Tueros Fernando Terry Carlos Alva‐Díaz Cerebral hemodynamic changes at high altitude in adults: a systematic review and meta-analysis of transcranial Doppler and duplex ultrasound studies |
| title | Cerebral hemodynamic changes at high altitude in adults: a systematic review and meta-analysis of transcranial Doppler and duplex ultrasound studies |
| title_full | Cerebral hemodynamic changes at high altitude in adults: a systematic review and meta-analysis of transcranial Doppler and duplex ultrasound studies |
| title_fullStr | Cerebral hemodynamic changes at high altitude in adults: a systematic review and meta-analysis of transcranial Doppler and duplex ultrasound studies |
| title_full_unstemmed | Cerebral hemodynamic changes at high altitude in adults: a systematic review and meta-analysis of transcranial Doppler and duplex ultrasound studies |
| title_short | Cerebral hemodynamic changes at high altitude in adults: a systematic review and meta-analysis of transcranial Doppler and duplex ultrasound studies |
| title_sort | cerebral hemodynamic changes at high altitude in adults a systematic review and meta analysis of transcranial doppler and duplex ultrasound studies |
| topic | high altitude cerebral hemodynamics cerebral blood flow velocity cerebral blood flow cerebral oxygen saturation cerebral arteries arterial diameter high-altitude adaptation cerebral perfusion High Altitude and Hypoxia Spaceflight effects on biology Thermoregulation and physiological responses |
| topic_facet | high altitude cerebral hemodynamics cerebral blood flow velocity cerebral blood flow cerebral oxygen saturation cerebral arteries arterial diameter high-altitude adaptation cerebral perfusion High Altitude and Hypoxia Spaceflight effects on biology Thermoregulation and physiological responses |
| url | https://doi.org/10.1152/japplphysiol.00176.2026 |
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