Cerebral hemodynamic changes at high altitude in adults: a systematic review and meta-analysis of transcranial Doppler and duplex ultrasound studies

In this first global meta-analysis of ultrasound-based cerebral hemodynamics at ≥1,500 m, we show that altitude exposure is associated with lower cerebral blood flow velocity, volumetric flow, arterial diameter, and oxygen saturation in healthy adults. Native status, age, and altitude level partly e...

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Autores principales: Jean Pierre Zila-Velasque, Pamela Grados‐Espinoza, Sebastian Abanto-Urbano, Mely Olarte-Durand, Martha Isabel Vilca-Salas, Paula Moran-Ballon, Carlos Quispe‐Vicuña, Victor Velásquez‐Rimachi, Joel M. Sequeiros, Kateriny Margot Regalado-Rodríguez, Patrick E. Zila-Velasque, Sthefano E. Zila-Velasque, Sheidy Clemente-Tueros, Fernando Terry, Carlos Alva‐Díaz
Formato: Artículo de revisión
Lenguaje:inglés
Publicado: 2026
Materias:
high altitude
cerebral hemodynamics
cerebral blood flow velocity
cerebral blood flow
cerebral oxygen saturation
cerebral arteries
arterial diameter
high-altitude adaptation
cerebral perfusion
High Altitude and Hypoxia
Spaceflight effects on biology
Thermoregulation and physiological responses
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Sumario:In this first global meta-analysis of ultrasound-based cerebral hemodynamics at ≥1,500 m, we show that altitude exposure is associated with lower cerebral blood flow velocity, volumetric flow, arterial diameter, and oxygen saturation in healthy adults. Native status, age, and altitude level partly explain marked heterogeneity. These findings highlight distinct adaptive patterns between native and nonnative populations and underscore the need for standardized, longitudinal studies of brain perfusion at altitude.

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