bla OXA−51 ‐Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in Peru

Background Common identification techniques do not differentiate among members of the Acinetobacter calcoaceticus–baumannii (ACB) complex, and the presence of non‐ baumannii Acinetobacter is often misinterpreted. The b l a OXA−51 gene is located within the chromosome of Acinetobacter baumannii . Des...

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Autores principales: Rosario Oporto-Llerena, Rosario Huerto-Huánuco, Yaneth Quispe-Hualpa, Luciano A. Palomino-Kobayashi, Maria Gabriela Soza Bieli-Bianchi, Jesús Rojas‐Jaimes, Patricia Gonzales, Luis Pollack, Andrea C. Gómez, Gina Salvador-Luján, Edwin Antonio Cuaresma Cuadros, Néstor Luque, Martín Casapía, Kovy Arteaga‐Livias, Yolanda Sáenz, María J. Pons, Joaquím Ruiz
Formato: Artículo
Lenguaje:inglés
Publicado: 2025
Materias:
Acinetobacter calcoaceticus-baumannii complex
blaOXA-51
Acinetobacter baumannii
antimicrobial resistance
urinary tract infection
community-acquired infections
nosocomial infections
species identification
Peru
Antibiotic Resistance in Bacteria
Infections and bacterial resistance
Bacterial Identification and Susceptibility Testing
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Sumario:Background Common identification techniques do not differentiate among members of the Acinetobacter calcoaceticus–baumannii (ACB) complex, and the presence of non‐ baumannii Acinetobacter is often misinterpreted. The b l a OXA−51 gene is located within the chromosome of Acinetobacter baumannii . Despite its plasmid dissemination to other members of the genus, it may be considered in initial species screening. Thus, this study aimed to determine the presence of b l a OXA−51 ‐negative Acinetobacter spp. as a cause of infection in Peru. Methods Two hundred ninety‐eight ACB complex isolates from different regions of Peru were isolated between January 2018 and March 2024. Of these, 272 and 25 were confirmed as hospital‐acquired and community infections, respectively. The presence of b l a OXA−51 was determined by polymerase chain reaction, and the susceptibility levels to 12 antimicrobial agents were determined. Results The results showed that 38 (12.7%) isolates were b l a OXA−51 ‐negative. These isolates were frequent among community infections (13/25, p < 0.0001), often causing urine infections. They showed significantly lower levels of resistance to almost all antimicrobial agents tested, and most of them were recovered from regions outside metropolitan Lima. Conclusion A relevant number of infections by non‐ baumannii Acinetobacter species in Peru is suggested, highlighting the need for systematic identification of these species in the country.

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