Management of Acute Pulmonary Embolism: Clinical Challenges and Therapeutic Strategies
Acute pulmonary embolism (PE) is one of the main cardiovascular emergencies, representing the third leading cause of death from vascular causes worldwide.Despite diagnostic advances, early recognition and appropriate management of PE still pose significant challenges to clinical practice, especially...
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2025
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| author | Ryan Rafael Barros de Macedo Denis Rossanez Rodrigues Ana Paula Fernandes Kainaki Vanessa Queiroz Carneiro Pedro de Luca Kassem Pedro Augusto Godinho de Castilho José Micael Delgado Barbosa Júlia Leite Justo Laura Andrea Rincón Arenas Matheus Santos Machado Matheus Cordeiro da Rocha Magalhães Cardoso Maria Vitória do Nascimento Silva |
| author_browse | Ana Paula Fernandes Kainaki Denis Rossanez Rodrigues José Micael Delgado Barbosa Júlia Leite Justo Laura Andrea Rincón Arenas Maria Vitória do Nascimento Silva Matheus Cordeiro da Rocha Magalhães Cardoso Matheus Santos Machado Pedro Augusto Godinho de Castilho Pedro de Luca Kassem Ryan Rafael Barros de Macedo Vanessa Queiroz Carneiro |
| author_facet | Ryan Rafael Barros de Macedo Denis Rossanez Rodrigues Ana Paula Fernandes Kainaki Vanessa Queiroz Carneiro Pedro de Luca Kassem Pedro Augusto Godinho de Castilho José Micael Delgado Barbosa Júlia Leite Justo Laura Andrea Rincón Arenas Matheus Santos Machado Matheus Cordeiro da Rocha Magalhães Cardoso Maria Vitória do Nascimento Silva |
| author_sort | Ryan Rafael Barros de Macedo |
| collection | Producción científica |
| description | Acute pulmonary embolism (PE) is one of the main cardiovascular emergencies, representing the third leading cause of death from vascular causes worldwide.Despite diagnostic advances, early recognition and appropriate management of PE still pose significant challenges to clinical practice, especially in cases classified as intermediate risk, where the therapeutic decision must be individualized and based on multiple parameters.This article carries out a narrative review of the literature, bringing together the most up-to-date evidence on the diagnosis, risk stratification and treatment of PE, with an emphasis on controversial aspects of management and strategies aimed at reducing morbidity and mortality.It highlights the central role of assessing right ventricular function, the careful use of biomarkers, the positive impact of multidisciplinary teams (PERT) and therapeutic innovations such as low-dose thrombolysis and catheter-directed interventions.The importance of longitudinal monitoring to prevent chronic complications, such as thromboembolic pulmonary hypertension, is also highlighted.Given the high prevalence and complexity of PE, technical mastery combined with an integrated, evidence-based approach is fundamental to optimizing clinical outcomes. |
| format | Article |
| id | openalex:W4412455952 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | openalex:W4412455952Management of Acute Pulmonary Embolism: Clinical Challenges and Therapeutic StrategiesRyan Rafael Barros de MacedoDenis Rossanez RodriguesAna Paula Fernandes KainakiVanessa Queiroz CarneiroPedro de Luca KassemPedro Augusto Godinho de CastilhoJosé Micael Delgado BarbosaJúlia Leite JustoLaura Andrea Rincón ArenasMatheus Santos MachadoMatheus Cordeiro da Rocha Magalhães CardosoMaria Vitória do Nascimento Silvaacute pulmonary embolismrisk stratificationsubmassive pulmonary embolismright ventricular functionbiomarkerslow-dose thrombolysiscatheter-directed interventionthromboembolic pulmonary hypertensionchronic complicationsanticoagulationmortality reductionVenous Thromboembolism Diagnosis and ManagementCardiovascular and Diving-Related ComplicationsPulmonary Hypertension Research and TreatmentsAcute pulmonary embolism (PE) is one of the main cardiovascular emergencies, representing the third leading cause of death from vascular causes worldwide.Despite diagnostic advances, early recognition and appropriate management of PE still pose significant challenges to clinical practice, especially in cases classified as intermediate risk, where the therapeutic decision must be individualized and based on multiple parameters.This article carries out a narrative review of the literature, bringing together the most up-to-date evidence on the diagnosis, risk stratification and treatment of PE, with an emphasis on controversial aspects of management and strategies aimed at reducing morbidity and mortality.It highlights the central role of assessing right ventricular function, the careful use of biomarkers, the positive impact of multidisciplinary teams (PERT) and therapeutic innovations such as low-dose thrombolysis and catheter-directed interventions.The importance of longitudinal monitoring to prevent chronic complications, such as thromboembolic pulmonary hypertension, is also highlighted.Given the high prevalence and complexity of PE, technical mastery combined with an integrated, evidence-based approach is fundamental to optimizing clinical outcomes.Articlehttps://doi.org/10.22533/at.ed.1595262514079https://atenaeditora.com.br/catalogo/dowload-post/98735W4412455952enInternational Journal of Health Science2764-01592025-07-14 |
| spellingShingle | acute pulmonary embolism risk stratification submassive pulmonary embolism right ventricular function biomarkers low-dose thrombolysis catheter-directed intervention thromboembolic pulmonary hypertension chronic complications anticoagulation mortality reduction Venous Thromboembolism Diagnosis and Management Cardiovascular and Diving-Related Complications Pulmonary Hypertension Research and Treatments Ryan Rafael Barros de Macedo Denis Rossanez Rodrigues Ana Paula Fernandes Kainaki Vanessa Queiroz Carneiro Pedro de Luca Kassem Pedro Augusto Godinho de Castilho José Micael Delgado Barbosa Júlia Leite Justo Laura Andrea Rincón Arenas Matheus Santos Machado Matheus Cordeiro da Rocha Magalhães Cardoso Maria Vitória do Nascimento Silva Management of Acute Pulmonary Embolism: Clinical Challenges and Therapeutic Strategies |
| title | Management of Acute Pulmonary Embolism: Clinical Challenges and Therapeutic Strategies |
| title_full | Management of Acute Pulmonary Embolism: Clinical Challenges and Therapeutic Strategies |
| title_fullStr | Management of Acute Pulmonary Embolism: Clinical Challenges and Therapeutic Strategies |
| title_full_unstemmed | Management of Acute Pulmonary Embolism: Clinical Challenges and Therapeutic Strategies |
| title_short | Management of Acute Pulmonary Embolism: Clinical Challenges and Therapeutic Strategies |
| title_sort | management of acute pulmonary embolism clinical challenges and therapeutic strategies |
| topic | acute pulmonary embolism risk stratification submassive pulmonary embolism right ventricular function biomarkers low-dose thrombolysis catheter-directed intervention thromboembolic pulmonary hypertension chronic complications anticoagulation mortality reduction Venous Thromboembolism Diagnosis and Management Cardiovascular and Diving-Related Complications Pulmonary Hypertension Research and Treatments |
| topic_facet | acute pulmonary embolism risk stratification submassive pulmonary embolism right ventricular function biomarkers low-dose thrombolysis catheter-directed intervention thromboembolic pulmonary hypertension chronic complications anticoagulation mortality reduction Venous Thromboembolism Diagnosis and Management Cardiovascular and Diving-Related Complications Pulmonary Hypertension Research and Treatments |
| url | https://doi.org/10.22533/at.ed.1595262514079 https://atenaeditora.com.br/catalogo/dowload-post/98735 |
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