Evaluación de la toxicidad de chalconas sintéticas con potencial anti-Leishmania en ratones BALB/c

OBJECTIVE: To evaluate the toxicity of three synthetic chalcones administered intraperitoneally to BALB/c mice. MATERIALS AND METHODS: The median lethal dose (LD50) was estimated by Dixon's Up-and-Down method. Subchronic toxicity of chalcones was evaluated at 20 and 40 mg/kg for 21 days. Behavi...

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Autores principales: Karina Cancino-Maldonado, Inés Castro, Carlos Yauri, Valérie Jullian, Jorge Arévalo, Michel Sauvain, Vanessa Adaui, Denis Castillo
Formato: Artículo
Lenguaje:español
Publicado: 2021
Materias:
Medicine
Molecular biology
Biology
Animals
Antiprotozoal Agents therapeutic use
Chalcone
Leishmaniasis
Mice, Inbred BALB C
Chalcones toxicity
Mice
Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies
Physical Sciences Chemistry Organic Chemistry Synthesis and biological activity
Health Sciences Medicine Surgery Natural Products and Biological Research
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Sumario:OBJECTIVE: To evaluate the toxicity of three synthetic chalcones administered intraperitoneally to BALB/c mice. MATERIALS AND METHODS: The median lethal dose (LD50) was estimated by Dixon's Up-and-Down method. Subchronic toxicity of chalcones was evaluated at 20 and 40 mg/kg for 21 days. Behavioral, physiological, biochemical, and histological toxic effects were evaluated. RESULTS: Chalcone 43 produced mucus in feces, visceral damage (liver) and alterations in organ coefficient (kidney, p = 0.037 and brain, p = 0.008) when compared to the control group. In addition, histological analysis showed that this chalcone produced edema, inflammation and necrosis in the evaluated organs, although there was no significant difference with the control. None of the biochemical parameters differed significantly between the treatment groups at 40 mg/kg dose and the control. CONCLUSIONS: The LD50 for all three chalcones was greater than 550 mg/kg of body weight. Chalcones 40 and 42 were found to be relatively non-toxic. Both can be considered safe for intraperitoneal application in BALB/c mice and, consequently, are potential candidates for use in the treatment of leishmaniasis.

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