Evaluación de la toxicidad de chalconas sintéticas con potencial anti-Leishmania en ratones BALB/c
OBJECTIVE: To evaluate the toxicity of three synthetic chalcones administered intraperitoneally to BALB/c mice. MATERIALS AND METHODS: The median lethal dose (LD50) was estimated by Dixon's Up-and-Down method. Subchronic toxicity of chalcones was evaluated at 20 and 40 mg/kg for 21 days. Behavi...
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2021
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| author | Karina Cancino-Maldonado Inés Castro Carlos Yauri Valérie Jullian Jorge Arévalo Michel Sauvain Vanessa Adaui Denis Castillo |
| author_browse | Carlos Yauri Denis Castillo Inés Castro Jorge Arévalo Karina Cancino-Maldonado Michel Sauvain Valérie Jullian Vanessa Adaui |
| author_facet | Karina Cancino-Maldonado Inés Castro Carlos Yauri Valérie Jullian Jorge Arévalo Michel Sauvain Vanessa Adaui Denis Castillo |
| author_sort | Karina Cancino-Maldonado |
| collection | Producción científica |
| description | OBJECTIVE: To evaluate the toxicity of three synthetic chalcones administered intraperitoneally to BALB/c mice. MATERIALS AND METHODS: The median lethal dose (LD50) was estimated by Dixon's Up-and-Down method. Subchronic toxicity of chalcones was evaluated at 20 and 40 mg/kg for 21 days. Behavioral, physiological, biochemical, and histological toxic effects were evaluated. RESULTS: Chalcone 43 produced mucus in feces, visceral damage (liver) and alterations in organ coefficient (kidney, p = 0.037 and brain, p = 0.008) when compared to the control group. In addition, histological analysis showed that this chalcone produced edema, inflammation and necrosis in the evaluated organs, although there was no significant difference with the control. None of the biochemical parameters differed significantly between the treatment groups at 40 mg/kg dose and the control. CONCLUSIONS: The LD50 for all three chalcones was greater than 550 mg/kg of body weight. Chalcones 40 and 42 were found to be relatively non-toxic. Both can be considered safe for intraperitoneal application in BALB/c mice and, consequently, are potential candidates for use in the treatment of leishmaniasis. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/909 |
| institution | UPeU |
| language | Spanish |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/9092026-10-30T16:14:58ZEvaluación de la toxicidad de chalconas sintéticas con potencial anti-Leishmania en ratones BALB/cKarina Cancino-MaldonadoInés CastroCarlos YauriValérie JullianJorge ArévaloMichel SauvainVanessa AdauiDenis CastilloMedicineMolecular biologyBiologyMedicineMolecular biologyBiologyAnimalsAnimalsAnimalsAntiprotozoal Agents therapeutic useAntiprotozoal Agents therapeutic useAntiprotozoal Agents therapeutic useChalconeChalconeChalconeLeishmaniasisLeishmaniasisLeishmaniasisMice, Inbred BALB CMice, Inbred BALB CMice, Inbred BALB CChalcones toxicityChalcones toxicityChalcones toxicityMiceMiceMiceHealth Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis StudiesPhysical Sciences Chemistry Organic Chemistry Synthesis and biological activityHealth Sciences Medicine Surgery Natural Products and Biological ResearchOBJECTIVE: To evaluate the toxicity of three synthetic chalcones administered intraperitoneally to BALB/c mice. MATERIALS AND METHODS: The median lethal dose (LD50) was estimated by Dixon's Up-and-Down method. Subchronic toxicity of chalcones was evaluated at 20 and 40 mg/kg for 21 days. Behavioral, physiological, biochemical, and histological toxic effects were evaluated. RESULTS: Chalcone 43 produced mucus in feces, visceral damage (liver) and alterations in organ coefficient (kidney, p = 0.037 and brain, p = 0.008) when compared to the control group. In addition, histological analysis showed that this chalcone produced edema, inflammation and necrosis in the evaluated organs, although there was no significant difference with the control. None of the biochemical parameters differed significantly between the treatment groups at 40 mg/kg dose and the control. CONCLUSIONS: The LD50 for all three chalcones was greater than 550 mg/kg of body weight. Chalcones 40 and 42 were found to be relatively non-toxic. Both can be considered safe for intraperitoneal application in BALB/c mice and, consequently, are potential candidates for use in the treatment of leishmaniasis.Articlehttps://pubmed.ncbi.nlm.nih.gov/34932744https://rpmesp.ins.gob.pe/index.php/rpmesp/article/download/6937/4368https://doi.org/10.17843/rpmesp.2021.383.693710.17843/rpmesp.2021.383.6937https://hdl.handle.net/20.500.15037/909W3197511246esRevista Peruana de Medicina Experimental y Salud Pública1726-46341726-46422021-09-042026-06-13T09:40:11Z2026-06-13T09:40:11Z |
| spellingShingle | Medicine Molecular biology Biology Medicine Molecular biology Biology Animals Animals Animals Antiprotozoal Agents therapeutic use Antiprotozoal Agents therapeutic use Antiprotozoal Agents therapeutic use Chalcone Chalcone Chalcone Leishmaniasis Leishmaniasis Leishmaniasis Mice, Inbred BALB C Mice, Inbred BALB C Mice, Inbred BALB C Chalcones toxicity Chalcones toxicity Chalcones toxicity Mice Mice Mice Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies Physical Sciences Chemistry Organic Chemistry Synthesis and biological activity Health Sciences Medicine Surgery Natural Products and Biological Research Karina Cancino-Maldonado Inés Castro Carlos Yauri Valérie Jullian Jorge Arévalo Michel Sauvain Vanessa Adaui Denis Castillo Evaluación de la toxicidad de chalconas sintéticas con potencial anti-Leishmania en ratones BALB/c |
| title | Evaluación de la toxicidad de chalconas sintéticas con potencial anti-Leishmania en ratones BALB/c |
| title_full | Evaluación de la toxicidad de chalconas sintéticas con potencial anti-Leishmania en ratones BALB/c |
| title_fullStr | Evaluación de la toxicidad de chalconas sintéticas con potencial anti-Leishmania en ratones BALB/c |
| title_full_unstemmed | Evaluación de la toxicidad de chalconas sintéticas con potencial anti-Leishmania en ratones BALB/c |
| title_short | Evaluación de la toxicidad de chalconas sintéticas con potencial anti-Leishmania en ratones BALB/c |
| title_sort | evaluacion de la toxicidad de chalconas sinteticas con potencial anti leishmania en ratones balb c |
| topic | Medicine Molecular biology Biology Medicine Molecular biology Biology Animals Animals Animals Antiprotozoal Agents therapeutic use Antiprotozoal Agents therapeutic use Antiprotozoal Agents therapeutic use Chalcone Chalcone Chalcone Leishmaniasis Leishmaniasis Leishmaniasis Mice, Inbred BALB C Mice, Inbred BALB C Mice, Inbred BALB C Chalcones toxicity Chalcones toxicity Chalcones toxicity Mice Mice Mice Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies Physical Sciences Chemistry Organic Chemistry Synthesis and biological activity Health Sciences Medicine Surgery Natural Products and Biological Research |
| topic_facet | Medicine Molecular biology Biology Medicine Molecular biology Biology Animals Animals Animals Antiprotozoal Agents therapeutic use Antiprotozoal Agents therapeutic use Antiprotozoal Agents therapeutic use Chalcone Chalcone Chalcone Leishmaniasis Leishmaniasis Leishmaniasis Mice, Inbred BALB C Mice, Inbred BALB C Mice, Inbred BALB C Chalcones toxicity Chalcones toxicity Chalcones toxicity Mice Mice Mice Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies Physical Sciences Chemistry Organic Chemistry Synthesis and biological activity Health Sciences Medicine Surgery Natural Products and Biological Research |
| url | https://pubmed.ncbi.nlm.nih.gov/34932744 https://rpmesp.ins.gob.pe/index.php/rpmesp/article/download/6937/4368 https://doi.org/10.17843/rpmesp.2021.383.6937 https://hdl.handle.net/20.500.15037/909 |
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