Clinical features of Guillain–Barré syndrome and factors associated with mortality during the 2019 outbreak in Peru
Peru has suffered an increase of Guillain Barre Syndrome incidence since 2015, being the biggest outbreak during 2019. We aimed to describe the clinical features, outcomes, and factors associated with mortality among cases reported in the 2019 outbreak. Cross-sectional analysis of data from the Nati...
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2022
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| author | Mary F. Reyes-Vega M. Gabriela Soto-Cabezas Anderson N. Soriano-Moreno Andree Valle-Campos Francisco Aquino-Peña Noemi Flores-Jaime Luis Ordoñez Ibargüen Kevin S. Martel César V. Munayco |
| author_browse | Anderson N. Soriano-Moreno Andree Valle-Campos César V. Munayco Francisco Aquino-Peña Kevin S. Martel Luis Ordoñez Ibargüen M. Gabriela Soto-Cabezas Mary F. Reyes-Vega Noemi Flores-Jaime |
| author_facet | Mary F. Reyes-Vega M. Gabriela Soto-Cabezas Anderson N. Soriano-Moreno Andree Valle-Campos Francisco Aquino-Peña Noemi Flores-Jaime Luis Ordoñez Ibargüen Kevin S. Martel César V. Munayco |
| author_sort | Mary F. Reyes-Vega |
| collection | Producción científica |
| description | Peru has suffered an increase of Guillain Barre Syndrome incidence since 2015, being the biggest outbreak during 2019. We aimed to describe the clinical features, outcomes, and factors associated with mortality among cases reported in the 2019 outbreak. Cross-sectional analysis of data from the National Surveillance of Guillain Barre Syndrome of the National Center for Control Disease and Prevention of Peru. We included all cases that met the Brighton criteria, level 1 to level 3. We used multivariable logistic regression to determinate factors associated with mortality. Overall, 772 cases were analyzed (58.7% male; mean age, 41.7 ± 20.3). 86.0% of cases aged over 30 years. 71.4% had a respiratory or gastrointestinal infection in the last 4 weeks. Case fatality rate was 4.3% and 32.2% of survivors reported sequelae. Axonal subtypes were identified in 75.6% of cases with an available nerve conduction study (38.7%). Age and impaired function of cranial nerves were independently associated with mortality. The 2019 outbreak of Guillain Barre syndrome in Peru was an unprecedented event that affected several regions of the country. Axonal damage was more frequent than demyelinating involvement, which is compatible with findings pointing to Campylobacter jejuni as the triggering agent. The case fatality rate was similar to that reported previously in Peru and other countries, but the high frequency of sequelae is striking. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/586 |
| institution | UPeU |
| language | English |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/5862026-11-02T22:34:06ZClinical features of Guillain–Barré syndrome and factors associated with mortality during the 2019 outbreak in PeruMary F. Reyes-VegaM. Gabriela Soto-CabezasAnderson N. Soriano-MorenoAndree Valle-CamposFrancisco Aquino-PeñaNoemi Flores-JaimeLuis Ordoñez IbargüenKevin S. MartelCésar V. MunaycoCase fatality rateMedicineOutbreakGuillain-Barre syndromeIncidence (geometry)Campylobacter jejuniPediatricsMortality rateLogistic regressionEpidemiologyInternal medicineVirologyPhysicsGeneticsBacteriaBiologyOpticsCase fatality rateMedicineOutbreakGuillain-Barre syndromeIncidence (geometry)Campylobacter jejuniPediatricsMortality rateLogistic regressionEpidemiologyInternal medicineVirologyAdultAdultAdultCross-Sectional StudiesCross-Sectional StudiesCross-Sectional StudiesDisease OutbreaksDisease OutbreaksDisease OutbreaksFemaleFemaleFemaleHumansHumansHumansMaleMaleMaleMiddle AgedMiddle AgedMiddle AgedPeru epidemiologyPeru epidemiologyPeru epidemiologyDisease ProgressionDisease ProgressionDisease ProgressionGuillain-Barre SyndromeGuillain-Barre SyndromeGuillain-Barre SyndromeYoung AdultYoung AdultYoung AdultHealth Sciences Medicine Neurology Peripheral Neuropathies and DisordersHealth Sciences Medicine Neurology Long-Term Effects of COVID-19Life Sciences Immunology and Microbiology Microbiology Bacterial Infections and VaccinesPeru has suffered an increase of Guillain Barre Syndrome incidence since 2015, being the biggest outbreak during 2019. We aimed to describe the clinical features, outcomes, and factors associated with mortality among cases reported in the 2019 outbreak. Cross-sectional analysis of data from the National Surveillance of Guillain Barre Syndrome of the National Center for Control Disease and Prevention of Peru. We included all cases that met the Brighton criteria, level 1 to level 3. We used multivariable logistic regression to determinate factors associated with mortality. Overall, 772 cases were analyzed (58.7% male; mean age, 41.7 ± 20.3). 86.0% of cases aged over 30 years. 71.4% had a respiratory or gastrointestinal infection in the last 4 weeks. Case fatality rate was 4.3% and 32.2% of survivors reported sequelae. Axonal subtypes were identified in 75.6% of cases with an available nerve conduction study (38.7%). Age and impaired function of cranial nerves were independently associated with mortality. The 2019 outbreak of Guillain Barre syndrome in Peru was an unprecedented event that affected several regions of the country. Axonal damage was more frequent than demyelinating involvement, which is compatible with findings pointing to Campylobacter jejuni as the triggering agent. The case fatality rate was similar to that reported previously in Peru and other countries, but the high frequency of sequelae is striking.Articlehttps://pubmed.ncbi.nlm.nih.gov/3609884010.1007/s00415-022-11331-4https://hdl.handle.net/20.500.15037/586W4295350330enJournal of Neurology0340-53541432-14592022-09-132026-06-13T08:18:05Z2026-06-13T08:18:05Z |
| spellingShingle | Case fatality rate Medicine Outbreak Guillain-Barre syndrome Incidence (geometry) Campylobacter jejuni Pediatrics Mortality rate Logistic regression Epidemiology Internal medicine Virology Physics Genetics Bacteria Biology Optics Case fatality rate Medicine Outbreak Guillain-Barre syndrome Incidence (geometry) Campylobacter jejuni Pediatrics Mortality rate Logistic regression Epidemiology Internal medicine Virology Adult Adult Adult Cross-Sectional Studies Cross-Sectional Studies Cross-Sectional Studies Disease Outbreaks Disease Outbreaks Disease Outbreaks Female Female Female Humans Humans Humans Male Male Male Middle Aged Middle Aged Middle Aged Peru epidemiology Peru epidemiology Peru epidemiology Disease Progression Disease Progression Disease Progression Guillain-Barre Syndrome Guillain-Barre Syndrome Guillain-Barre Syndrome Young Adult Young Adult Young Adult Health Sciences Medicine Neurology Peripheral Neuropathies and Disorders Health Sciences Medicine Neurology Long-Term Effects of COVID-19 Life Sciences Immunology and Microbiology Microbiology Bacterial Infections and Vaccines Mary F. Reyes-Vega M. Gabriela Soto-Cabezas Anderson N. Soriano-Moreno Andree Valle-Campos Francisco Aquino-Peña Noemi Flores-Jaime Luis Ordoñez Ibargüen Kevin S. Martel César V. Munayco Clinical features of Guillain–Barré syndrome and factors associated with mortality during the 2019 outbreak in Peru |
| title | Clinical features of Guillain–Barré syndrome and factors associated with mortality during the 2019 outbreak in Peru |
| title_full | Clinical features of Guillain–Barré syndrome and factors associated with mortality during the 2019 outbreak in Peru |
| title_fullStr | Clinical features of Guillain–Barré syndrome and factors associated with mortality during the 2019 outbreak in Peru |
| title_full_unstemmed | Clinical features of Guillain–Barré syndrome and factors associated with mortality during the 2019 outbreak in Peru |
| title_short | Clinical features of Guillain–Barré syndrome and factors associated with mortality during the 2019 outbreak in Peru |
| title_sort | clinical features of guillain barre syndrome and factors associated with mortality during the 2019 outbreak in peru |
| topic | Case fatality rate Medicine Outbreak Guillain-Barre syndrome Incidence (geometry) Campylobacter jejuni Pediatrics Mortality rate Logistic regression Epidemiology Internal medicine Virology Physics Genetics Bacteria Biology Optics Case fatality rate Medicine Outbreak Guillain-Barre syndrome Incidence (geometry) Campylobacter jejuni Pediatrics Mortality rate Logistic regression Epidemiology Internal medicine Virology Adult Adult Adult Cross-Sectional Studies Cross-Sectional Studies Cross-Sectional Studies Disease Outbreaks Disease Outbreaks Disease Outbreaks Female Female Female Humans Humans Humans Male Male Male Middle Aged Middle Aged Middle Aged Peru epidemiology Peru epidemiology Peru epidemiology Disease Progression Disease Progression Disease Progression Guillain-Barre Syndrome Guillain-Barre Syndrome Guillain-Barre Syndrome Young Adult Young Adult Young Adult Health Sciences Medicine Neurology Peripheral Neuropathies and Disorders Health Sciences Medicine Neurology Long-Term Effects of COVID-19 Life Sciences Immunology and Microbiology Microbiology Bacterial Infections and Vaccines |
| topic_facet | Case fatality rate Medicine Outbreak Guillain-Barre syndrome Incidence (geometry) Campylobacter jejuni Pediatrics Mortality rate Logistic regression Epidemiology Internal medicine Virology Physics Genetics Bacteria Biology Optics Case fatality rate Medicine Outbreak Guillain-Barre syndrome Incidence (geometry) Campylobacter jejuni Pediatrics Mortality rate Logistic regression Epidemiology Internal medicine Virology Adult Adult Adult Cross-Sectional Studies Cross-Sectional Studies Cross-Sectional Studies Disease Outbreaks Disease Outbreaks Disease Outbreaks Female Female Female Humans Humans Humans Male Male Male Middle Aged Middle Aged Middle Aged Peru epidemiology Peru epidemiology Peru epidemiology Disease Progression Disease Progression Disease Progression Guillain-Barre Syndrome Guillain-Barre Syndrome Guillain-Barre Syndrome Young Adult Young Adult Young Adult Health Sciences Medicine Neurology Peripheral Neuropathies and Disorders Health Sciences Medicine Neurology Long-Term Effects of COVID-19 Life Sciences Immunology and Microbiology Microbiology Bacterial Infections and Vaccines |
| url | https://pubmed.ncbi.nlm.nih.gov/36098840 https://hdl.handle.net/20.500.15037/586 |
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