Body Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American Countries
Introduction:In South America, the rise in chronic respiratory diseases and weight-related issues due to the ongoing epidemiological transition has prompted research into their interrelationship. Methods:We sought to assess the association between body mass index (BMI) and bronchodilator responsiven...
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2025
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| author | Anderson N. Soriano-Moreno Andrés G. Lescano Robert H. Gilman J. Jaime Miranda Antonio Bernabé‐Ortiz Adolfo Rubinstein Laura Gutiérrez Vilma Irazola Robert A. Wise William Checkley |
| author_browse | Adolfo Rubinstein Anderson N. Soriano-Moreno Andrés G. Lescano Antonio Bernabé‐Ortiz J. Jaime Miranda Laura Gutiérrez Robert A. Wise Robert H. Gilman Vilma Irazola William Checkley |
| author_facet | Anderson N. Soriano-Moreno Andrés G. Lescano Robert H. Gilman J. Jaime Miranda Antonio Bernabé‐Ortiz Adolfo Rubinstein Laura Gutiérrez Vilma Irazola Robert A. Wise William Checkley |
| author_sort | Anderson N. Soriano-Moreno |
| collection | Producción científica |
| description | Introduction:In South America, the rise in chronic respiratory diseases and weight-related issues due to the ongoing epidemiological transition has prompted research into their interrelationship. Methods:We sought to assess the association between body mass index (BMI) and bronchodilator responsiveness (BDR) among adults in Peru, Chile, Uruguay, and Argentina, using population-based data from two cohort studies.We defined BDR as a 12% and 200 mL increase in either forced expiratory volume in one second (FEV1) or forced vital capacity (FVC) after administration of a short-acting bronchodilator.The analysis also distinguished between FEV-and FVC-specific BDR.We used logistic regression adjusted for confounders to evaluate associations with BMI.Results: Among 7,160 participants (55.2% men, mean age 57.3 years), 23.7% had a BMI <25 kg/m and 35.5% had a BMI 30 kg/m.Overall, 9.5% met the criteria for BDR; with 7.8% showing FEV1specific and 4.9% FVC-specific responses.Compared to a BMI of 20-24.9kg/m, a BMI 30 kg/m was associated with higher odds of FVC-specific BDR (adjusted OR = 1.47, 95% CI 1.08-2.03),whereas a BMI <20 kg/m was associated with FEV-specific BDR among participants with asthma (6.34, 1.16-35.1)and chronic bronchitis (4.71, 1.28-15.9),and with higher odds of any BDR in those with chronic bronchitis (3.90, 1.19-11.93). Conclusion:There was a differential relationship between BMI and types of BDR: higher BMI was associated with FVC-specific responsiveness, whereas lower BMI was linked to FEV-specific BDR in individuals with asthma and chronic bronchitis and to overall BDR in those with chronic bronchitis. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/571 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/5712026-10-30T16:14:41ZBody Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American CountriesAnderson N. Soriano-MorenoAndrés G. LescanoRobert H. GilmanJ. Jaime MirandaAntonio Bernabé‐OrtizAdolfo RubinsteinLaura GutiérrezVilma IrazolaRobert A. WiseWilliam CheckleyMedicineBody mass indexAsthmaBronchodilatorChronic bronchitisDemographyBronchitisAfrican americanEnvironmental healthBronchodilator Agentsβ2 adrenergic receptorInternal medicineGerontologyDifferential (mechanical device)PediatricsPhysical therapyPhysical activityBody mass indexAsthmaBronchodilatorChronic bronchitisBronchitisAfrican americanHealth Sciences Medicine Complementary and alternative medicine Cardiovascular and exercise physiologySocial Sciences Psychology Social Psychology Psychological Well-being and Life SatisfactionHealth Sciences Medicine Cardiology and Cardiovascular Medicine Blood Pressure and Hypertension StudiesIntroduction:In South America, the rise in chronic respiratory diseases and weight-related issues due to the ongoing epidemiological transition has prompted research into their interrelationship. Methods:We sought to assess the association between body mass index (BMI) and bronchodilator responsiveness (BDR) among adults in Peru, Chile, Uruguay, and Argentina, using population-based data from two cohort studies.We defined BDR as a 12% and 200 mL increase in either forced expiratory volume in one second (FEV1) or forced vital capacity (FVC) after administration of a short-acting bronchodilator.The analysis also distinguished between FEV-and FVC-specific BDR.We used logistic regression adjusted for confounders to evaluate associations with BMI.Results: Among 7,160 participants (55.2% men, mean age 57.3 years), 23.7% had a BMI <25 kg/m and 35.5% had a BMI 30 kg/m.Overall, 9.5% met the criteria for BDR; with 7.8% showing FEV1specific and 4.9% FVC-specific responses.Compared to a BMI of 20-24.9kg/m, a BMI 30 kg/m was associated with higher odds of FVC-specific BDR (adjusted OR = 1.47, 95% CI 1.08-2.03),whereas a BMI <20 kg/m was associated with FEV-specific BDR among participants with asthma (6.34, 1.16-35.1)and chronic bronchitis (4.71, 1.28-15.9),and with higher odds of any BDR in those with chronic bronchitis (3.90, 1.19-11.93). Conclusion:There was a differential relationship between BMI and types of BDR: higher BMI was associated with FVC-specific responsiveness, whereas lower BMI was linked to FEV-specific BDR in individuals with asthma and chronic bronchitis and to overall BDR in those with chronic bronchitis.Articlehttps://pubmed.ncbi.nlm.nih.gov/41046133https://doi.org/10.15326/jcopdf.2025.060810.15326/jcopdf.2025.0608https://hdl.handle.net/20.500.15037/571W4414791602enChronic Obstructive Pulmonary Diseases Journal of the COPD Foundation2372-952X2025-01-012026-06-13T08:17:40Z2026-06-13T08:17:40Z |
| spellingShingle | Medicine Body mass index Asthma Bronchodilator Chronic bronchitis Demography Bronchitis African american Environmental health Bronchodilator Agents β2 adrenergic receptor Internal medicine Gerontology Differential (mechanical device) Pediatrics Physical therapy Physical activity Body mass index Asthma Bronchodilator Chronic bronchitis Bronchitis African american Health Sciences Medicine Complementary and alternative medicine Cardiovascular and exercise physiology Social Sciences Psychology Social Psychology Psychological Well-being and Life Satisfaction Health Sciences Medicine Cardiology and Cardiovascular Medicine Blood Pressure and Hypertension Studies Anderson N. Soriano-Moreno Andrés G. Lescano Robert H. Gilman J. Jaime Miranda Antonio Bernabé‐Ortiz Adolfo Rubinstein Laura Gutiérrez Vilma Irazola Robert A. Wise William Checkley Body Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American Countries |
| title | Body Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American Countries |
| title_full | Body Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American Countries |
| title_fullStr | Body Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American Countries |
| title_full_unstemmed | Body Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American Countries |
| title_short | Body Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American Countries |
| title_sort | body mass index and bronchodilator responsiveness in adults analysis of 2 population based studies in 4 south american countries |
| topic | Medicine Body mass index Asthma Bronchodilator Chronic bronchitis Demography Bronchitis African american Environmental health Bronchodilator Agents β2 adrenergic receptor Internal medicine Gerontology Differential (mechanical device) Pediatrics Physical therapy Physical activity Body mass index Asthma Bronchodilator Chronic bronchitis Bronchitis African american Health Sciences Medicine Complementary and alternative medicine Cardiovascular and exercise physiology Social Sciences Psychology Social Psychology Psychological Well-being and Life Satisfaction Health Sciences Medicine Cardiology and Cardiovascular Medicine Blood Pressure and Hypertension Studies |
| topic_facet | Medicine Body mass index Asthma Bronchodilator Chronic bronchitis Demography Bronchitis African american Environmental health Bronchodilator Agents β2 adrenergic receptor Internal medicine Gerontology Differential (mechanical device) Pediatrics Physical therapy Physical activity Body mass index Asthma Bronchodilator Chronic bronchitis Bronchitis African american Health Sciences Medicine Complementary and alternative medicine Cardiovascular and exercise physiology Social Sciences Psychology Social Psychology Psychological Well-being and Life Satisfaction Health Sciences Medicine Cardiology and Cardiovascular Medicine Blood Pressure and Hypertension Studies |
| url | https://pubmed.ncbi.nlm.nih.gov/41046133 https://doi.org/10.15326/jcopdf.2025.0608 https://hdl.handle.net/20.500.15037/571 |
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