Body Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American Countries

Introduction:In South America, the rise in chronic respiratory diseases and weight-related issues due to the ongoing epidemiological transition has prompted research into their interrelationship. Methods:We sought to assess the association between body mass index (BMI) and bronchodilator responsiven...

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Autores principales: Anderson N. Soriano-Moreno, Andrés G. Lescano, Robert H. Gilman, J. Jaime Miranda, Antonio Bernabé‐Ortiz, Adolfo Rubinstein, Laura Gutiérrez, Vilma Irazola, Robert A. Wise, William Checkley
Formato: Artículo
Lenguaje:inglés
Publicado: 2025
Materias:
Medicine
Body mass index
Asthma
Bronchodilator
Chronic bronchitis
Demography
Bronchitis
African american
Environmental health
Bronchodilator Agents
β2 adrenergic receptor
Internal medicine
Gerontology
Differential (mechanical device)
Pediatrics
Physical therapy
Physical activity
Health Sciences Medicine Complementary and alternative medicine Cardiovascular and exercise physiology
Social Sciences Psychology Social Psychology Psychological Well-being and Life Satisfaction
Health Sciences Medicine Cardiology and Cardiovascular Medicine Blood Pressure and Hypertension Studies
Acceso en línea:Ver en el sistema de origen
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Sumario:Introduction:In South America, the rise in chronic respiratory diseases and weight-related issues due to the ongoing epidemiological transition has prompted research into their interrelationship. Methods:We sought to assess the association between body mass index (BMI) and bronchodilator responsiveness (BDR) among adults in Peru, Chile, Uruguay, and Argentina, using population-based data from two cohort studies.We defined BDR as a 12% and 200 mL increase in either forced expiratory volume in one second (FEV1) or forced vital capacity (FVC) after administration of a short-acting bronchodilator.The analysis also distinguished between FEV-and FVC-specific BDR.We used logistic regression adjusted for confounders to evaluate associations with BMI.Results: Among 7,160 participants (55.2% men, mean age 57.3 years), 23.7% had a BMI <25 kg/m and 35.5% had a BMI 30 kg/m.Overall, 9.5% met the criteria for BDR; with 7.8% showing FEV1specific and 4.9% FVC-specific responses.Compared to a BMI of 20-24.9kg/m, a BMI 30 kg/m was associated with higher odds of FVC-specific BDR (adjusted OR = 1.47, 95% CI 1.08-2.03),whereas a BMI <20 kg/m was associated with FEV-specific BDR among participants with asthma (6.34, 1.16-35.1)and chronic bronchitis (4.71, 1.28-15.9),and with higher odds of any BDR in those with chronic bronchitis (3.90, 1.19-11.93). Conclusion:There was a differential relationship between BMI and types of BDR: higher BMI was associated with FVC-specific responsiveness, whereas lower BMI was linked to FEV-specific BDR in individuals with asthma and chronic bronchitis and to overall BDR in those with chronic bronchitis.

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