Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
INTRODUCTION: Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim of the study was to describe the clinical features of hospitalized adult patients with COVID-19 and to determine the prognostic factors associated with in-hospita...
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| Formato: | Artículo |
| Lenguaje: | inglés |
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2020
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| _version_ | 1881761957882626048 |
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| author | Mejía, Fernando Medina, Carlos Cornejo, Enrique Morello, Enrique Vásquez, Sergio Alave Rosas, Jorge Luis Schwalb, Alvaro Málaga, Germán |
| author_browse | Alave Rosas, Jorge Luis Cornejo, Enrique Medina, Carlos Mejía, Fernando Morello, Enrique Málaga, Germán Schwalb, Alvaro Vásquez, Sergio |
| author_facet | Mejía, Fernando Medina, Carlos Cornejo, Enrique Morello, Enrique Vásquez, Sergio Alave Rosas, Jorge Luis Schwalb, Alvaro Málaga, Germán |
| author_sort | Mejía, Fernando |
| collection | Producción científica |
| description | INTRODUCTION: Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim of the study was to describe the clinical features of hospitalized adult patients with COVID-19 and to determine the prognostic factors associated with in-hospital mortality. METHODS: We conducted a retrospective cohort study among adult patients with COVID-19 admitted to Hospital Cayetano Heredia; a tertiary care hospital in Lima, Peru. The primary outcome was in-hospital mortality. Multivariate Cox proportional hazards regression was used to identify factors independently associated with in-hospital mortality. RESULTS: A total of 369 patients (median age 59 years [IQR:49-68]; 241 (65.31%) male) were included. Most patients (68.56%) reported at least one comorbidity; more frequently: obesity (42.55%), diabetes mellitus (21.95%), and hypertension (21.68%). The median duration of symptoms prior to hospital admission was 7 days (IQR: 5-10). Reported in-hospital mortality was 49.59%. By multiple Cox regression, oxygen saturation (SaO2) values of less than 90% on admission correlated with mortality, presenting 1.86 (95%CI: 1.02-3.39), 4.44 (95%CI: 2.46-8.02) and 7.74 (95%CI: 4.54-13.19) times greater risk of death for SaO2 of 89-85%, 84-80% and <80%, respectively, when compared to patients with SaO2 >90%. Additionally, age >60 years was associated with 1.88 times greater mortality. CONCLUSIONS: Oxygen saturation below 90% on admission is a strong predictor of in-hospital mortality in patients with COVID-19. In settings with limited resources, efforts to reduce mortality in COVID-19 should focus on early identification of hypoxemia and timely access to hospital care. |
| format | Article |
| fuente_str | CRIS |
| fuente_tipo_str_mv | CRIS|Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/178 |
| institution | UPeU |
| language | English |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/1782026-11-02T22:00:04ZOxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, PeruMejía, FernandoMedina, CarlosCornejo, EnriqueMorello, EnriqueVásquez, SergioAlave Rosas, Jorge LuisSchwalb, AlvaroMálaga, GermánINTRODUCTION: Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim of the study was to describe the clinical features of hospitalized adult patients with COVID-19 and to determine the prognostic factors associated with in-hospital mortality. METHODS: We conducted a retrospective cohort study among adult patients with COVID-19 admitted to Hospital Cayetano Heredia; a tertiary care hospital in Lima, Peru. The primary outcome was in-hospital mortality. Multivariate Cox proportional hazards regression was used to identify factors independently associated with in-hospital mortality. RESULTS: A total of 369 patients (median age 59 years [IQR:49-68]; 241 (65.31%) male) were included. Most patients (68.56%) reported at least one comorbidity; more frequently: obesity (42.55%), diabetes mellitus (21.95%), and hypertension (21.68%). The median duration of symptoms prior to hospital admission was 7 days (IQR: 5-10). Reported in-hospital mortality was 49.59%. By multiple Cox regression, oxygen saturation (SaO2) values of less than 90% on admission correlated with mortality, presenting 1.86 (95%CI: 1.02-3.39), 4.44 (95%CI: 2.46-8.02) and 7.74 (95%CI: 4.54-13.19) times greater risk of death for SaO2 of 89-85%, 84-80% and <80%, respectively, when compared to patients with SaO2 >90%. Additionally, age >60 years was associated with 1.88 times greater mortality. CONCLUSIONS: Oxygen saturation below 90% on admission is a strong predictor of in-hospital mortality in patients with COVID-19. In settings with limited resources, efforts to reduce mortality in COVID-19 should focus on early identification of hypoxemia and timely access to hospital care.Articlehttps://pubmed.ncbi.nlm.nih.gov/33370364https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244171&type=printablehttps://doi.org/10.1371/journal.pone.0244171PMC776947910.1371/journal.pone.0244171https://hdl.handle.net/20.500.15037/17833370364W3117227522enPLoS ONE1932-62032020-12-282026-06-13T07:49:02Z2026-06-13T07:49:02Z |
| spellingShingle | Mejía, Fernando Medina, Carlos Cornejo, Enrique Morello, Enrique Vásquez, Sergio Alave Rosas, Jorge Luis Schwalb, Alvaro Málaga, Germán Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru |
| title | Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru |
| title_full | Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru |
| title_fullStr | Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru |
| title_full_unstemmed | Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru |
| title_short | Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru |
| title_sort | oxygen saturation as a predictor of mortality in hospitalized adult patients with covid 19 in a public hospital in lima peru |
| url | https://pubmed.ncbi.nlm.nih.gov/33370364 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244171&type=printable https://doi.org/10.1371/journal.pone.0244171 https://hdl.handle.net/20.500.15037/178 |
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