Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru

INTRODUCTION: Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim of the study was to describe the clinical features of hospitalized adult patients with COVID-19 and to determine the prognostic factors associated with in-hospita...

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Autores principales: Mejía, Fernando, Medina, Carlos, Cornejo, Enrique, Morello, Enrique, Vásquez, Sergio, Alave Rosas, Jorge Luis, Schwalb, Alvaro, Málaga, Germán
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Publicado: 2020
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author Mejía, Fernando
Medina, Carlos
Cornejo, Enrique
Morello, Enrique
Vásquez, Sergio
Alave Rosas, Jorge Luis
Schwalb, Alvaro
Málaga, Germán
author_browse Alave Rosas, Jorge Luis
Cornejo, Enrique
Medina, Carlos
Mejía, Fernando
Morello, Enrique
Málaga, Germán
Schwalb, Alvaro
Vásquez, Sergio
author_facet Mejía, Fernando
Medina, Carlos
Cornejo, Enrique
Morello, Enrique
Vásquez, Sergio
Alave Rosas, Jorge Luis
Schwalb, Alvaro
Málaga, Germán
author_sort Mejía, Fernando
collection Producción científica
description INTRODUCTION: Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim of the study was to describe the clinical features of hospitalized adult patients with COVID-19 and to determine the prognostic factors associated with in-hospital mortality. METHODS: We conducted a retrospective cohort study among adult patients with COVID-19 admitted to Hospital Cayetano Heredia; a tertiary care hospital in Lima, Peru. The primary outcome was in-hospital mortality. Multivariate Cox proportional hazards regression was used to identify factors independently associated with in-hospital mortality. RESULTS: A total of 369 patients (median age 59 years [IQR:49-68]; 241 (65.31%) male) were included. Most patients (68.56%) reported at least one comorbidity; more frequently: obesity (42.55%), diabetes mellitus (21.95%), and hypertension (21.68%). The median duration of symptoms prior to hospital admission was 7 days (IQR: 5-10). Reported in-hospital mortality was 49.59%. By multiple Cox regression, oxygen saturation (SaO2) values of less than 90% on admission correlated with mortality, presenting 1.86 (95%CI: 1.02-3.39), 4.44 (95%CI: 2.46-8.02) and 7.74 (95%CI: 4.54-13.19) times greater risk of death for SaO2 of 89-85%, 84-80% and <80%, respectively, when compared to patients with SaO2 >90%. Additionally, age >60 years was associated with 1.88 times greater mortality. CONCLUSIONS: Oxygen saturation below 90% on admission is a strong predictor of in-hospital mortality in patients with COVID-19. In settings with limited resources, efforts to reduce mortality in COVID-19 should focus on early identification of hypoxemia and timely access to hospital care.
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spelling oai:cris.upeu.edu.pe:20.500.15037/1782026-11-02T22:00:04ZOxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, PeruMejía, FernandoMedina, CarlosCornejo, EnriqueMorello, EnriqueVásquez, SergioAlave Rosas, Jorge LuisSchwalb, AlvaroMálaga, GermánINTRODUCTION: Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim of the study was to describe the clinical features of hospitalized adult patients with COVID-19 and to determine the prognostic factors associated with in-hospital mortality. METHODS: We conducted a retrospective cohort study among adult patients with COVID-19 admitted to Hospital Cayetano Heredia; a tertiary care hospital in Lima, Peru. The primary outcome was in-hospital mortality. Multivariate Cox proportional hazards regression was used to identify factors independently associated with in-hospital mortality. RESULTS: A total of 369 patients (median age 59 years [IQR:49-68]; 241 (65.31%) male) were included. Most patients (68.56%) reported at least one comorbidity; more frequently: obesity (42.55%), diabetes mellitus (21.95%), and hypertension (21.68%). The median duration of symptoms prior to hospital admission was 7 days (IQR: 5-10). Reported in-hospital mortality was 49.59%. By multiple Cox regression, oxygen saturation (SaO2) values of less than 90% on admission correlated with mortality, presenting 1.86 (95%CI: 1.02-3.39), 4.44 (95%CI: 2.46-8.02) and 7.74 (95%CI: 4.54-13.19) times greater risk of death for SaO2 of 89-85%, 84-80% and <80%, respectively, when compared to patients with SaO2 >90%. Additionally, age >60 years was associated with 1.88 times greater mortality. CONCLUSIONS: Oxygen saturation below 90% on admission is a strong predictor of in-hospital mortality in patients with COVID-19. In settings with limited resources, efforts to reduce mortality in COVID-19 should focus on early identification of hypoxemia and timely access to hospital care.Articlehttps://pubmed.ncbi.nlm.nih.gov/33370364https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244171&type=printablehttps://doi.org/10.1371/journal.pone.0244171PMC776947910.1371/journal.pone.0244171https://hdl.handle.net/20.500.15037/17833370364W3117227522enPLoS ONE1932-62032020-12-282026-06-13T07:49:02Z2026-06-13T07:49:02Z
spellingShingle Mejía, Fernando
Medina, Carlos
Cornejo, Enrique
Morello, Enrique
Vásquez, Sergio
Alave Rosas, Jorge Luis
Schwalb, Alvaro
Málaga, Germán
Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
title Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
title_full Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
title_fullStr Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
title_full_unstemmed Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
title_short Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru
title_sort oxygen saturation as a predictor of mortality in hospitalized adult patients with covid 19 in a public hospital in lima peru
url https://pubmed.ncbi.nlm.nih.gov/33370364
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244171&type=printable
https://doi.org/10.1371/journal.pone.0244171
https://hdl.handle.net/20.500.15037/178
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