Possible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholics
The rate of ethanol metabolism (EMR) was determined in alcoholic patients with or without hepatic necrosis, steatosis, and/or cirrhosis. Fifty six cases were studied after 9–25 days of abstinence (mean 15 days). A significant increase in EMR (P<0.01) was found in alcoholics with hepatic necrosis...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
1977
|
| Materias: | |
| Acceso en línea: | Ver en el sistema de origen Enlace permanente (DOI o Handle) |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | The rate of ethanol metabolism (EMR) was determined in alcoholic patients with or without hepatic necrosis, steatosis, and/or cirrhosis. Fifty six cases were studied after 9–25 days of abstinence (mean 15 days). A significant increase in EMR (P<0.01) was found in alcoholics with hepatic necrosis (265±20.5 mg/kg/hr) compared with alcoholics with normal liver histology (154±17) and nonalcoholic controls (159±15). In alcoholics with liver steatosis but without necrosis a lesser increase in EMR (207±20,P<0.05) was also observed. Patients with slight fibrosis but without other abnormalities in their liver biopsies and cirrhotics with overt liver failure (jaundice, ascites) showed EMR similar to controls. |
|---|