Possible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholics
The rate of ethanol metabolism (EMR) was determined in alcoholic patients with or without hepatic necrosis, steatosis, and/or cirrhosis. Fifty six cases were studied after 9–25 days of abstinence (mean 15 days). A significant increase in EMR (P<0.01) was found in alcoholics with hepatic necrosis...
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1977
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| _version_ | 1881508964218175488 |
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| author | G Ugarte Hern�n Iturriaga T Pereda |
| author_browse | G Ugarte Hern�n Iturriaga T Pereda |
| author_facet | G Ugarte Hern�n Iturriaga T Pereda |
| author_sort | G Ugarte |
| collection | Producción científica |
| description | The rate of ethanol metabolism (EMR) was determined in alcoholic patients with or without hepatic necrosis, steatosis, and/or cirrhosis. Fifty six cases were studied after 9–25 days of abstinence (mean 15 days). A significant increase in EMR (P<0.01) was found in alcoholics with hepatic necrosis (265±20.5 mg/kg/hr) compared with alcoholics with normal liver histology (154±17) and nonalcoholic controls (159±15). In alcoholics with liver steatosis but without necrosis a lesser increase in EMR (207±20,P<0.05) was also observed. Patients with slight fibrosis but without other abnormalities in their liver biopsies and cirrhotics with overt liver failure (jaundice, ascites) showed EMR similar to controls. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1688 |
| institution | UPeU |
| language | English |
| publishDate | 1977 |
| publishDateRange | 1977 |
| publishDateSort | 1977 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/16882026-11-02T22:34:06ZPossible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholicsG UgarteHern�n IturriagaT PeredaSteatosisGastroenterologyInternal medicineCirrhosisAscitesMedicineAbstinenceNecrosisAlcoholic liver diseaseFibrosisEthanolJaundicePathologyBiologyPsychiatryBiochemistrySteatosisGastroenterologyInternal medicineCirrhosisAscitesMedicineAbstinenceNecrosisAlcoholic liver diseaseFibrosisEthanolJaundicePathologyBiologyPsychiatryAdultAdultAdultEthanol metabolismEthanol metabolismEthanol metabolismAlcoholism metabolismAlcoholism metabolismAlcoholism metabolismBiopsyBiopsyBiopsyChronic DiseaseChronic DiseaseChronic DiseaseFatty Liver metabolismFatty Liver metabolismFatty Liver metabolismHumansHumansHumansLiver pathologyLiver pathologyLiver pathologyLiver Cirrhosis metabolismLiver Cirrhosis metabolismLiver Cirrhosis metabolismLiver Diseases metabolismLiver Diseases metabolismLiver Diseases metabolismMaleMaleMaleMiddle AgedMiddle AgedMiddle AgedNecrosisNecrosisNecrosisChemical and Drug Induced Liver Injury metabolismChemical and Drug Induced Liver Injury metabolismChemical and Drug Induced Liver Injury metabolismHealth Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health EffectsHealth Sciences Medicine Epidemiology Liver Disease Diagnosis and TreatmentHealth Sciences Medicine Hepatology Liver Disease and TransplantationThe rate of ethanol metabolism (EMR) was determined in alcoholic patients with or without hepatic necrosis, steatosis, and/or cirrhosis. Fifty six cases were studied after 9–25 days of abstinence (mean 15 days). A significant increase in EMR (P<0.01) was found in alcoholics with hepatic necrosis (265±20.5 mg/kg/hr) compared with alcoholics with normal liver histology (154±17) and nonalcoholic controls (159±15). In alcoholics with liver steatosis but without necrosis a lesser increase in EMR (207±20,P<0.05) was also observed. Patients with slight fibrosis but without other abnormalities in their liver biopsies and cirrhotics with overt liver failure (jaundice, ascites) showed EMR similar to controls.Articlehttps://pubmed.ncbi.nlm.nih.gov/85766110.1007/bf01071886https://hdl.handle.net/20.500.15037/1688W1987607701enDigestive Diseases and Sciences0163-21161573-25681977-05-012026-06-13T14:18:50Z2026-06-13T14:18:50Z |
| spellingShingle | Steatosis Gastroenterology Internal medicine Cirrhosis Ascites Medicine Abstinence Necrosis Alcoholic liver disease Fibrosis Ethanol Jaundice Pathology Biology Psychiatry Biochemistry Steatosis Gastroenterology Internal medicine Cirrhosis Ascites Medicine Abstinence Necrosis Alcoholic liver disease Fibrosis Ethanol Jaundice Pathology Biology Psychiatry Adult Adult Adult Ethanol metabolism Ethanol metabolism Ethanol metabolism Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Biopsy Biopsy Biopsy Chronic Disease Chronic Disease Chronic Disease Fatty Liver metabolism Fatty Liver metabolism Fatty Liver metabolism Humans Humans Humans Liver pathology Liver pathology Liver pathology Liver Cirrhosis metabolism Liver Cirrhosis metabolism Liver Cirrhosis metabolism Liver Diseases metabolism Liver Diseases metabolism Liver Diseases metabolism Male Male Male Middle Aged Middle Aged Middle Aged Necrosis Necrosis Necrosis Chemical and Drug Induced Liver Injury metabolism Chemical and Drug Induced Liver Injury metabolism Chemical and Drug Induced Liver Injury metabolism Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Health Sciences Medicine Hepatology Liver Disease and Transplantation G Ugarte Hern�n Iturriaga T Pereda Possible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholics |
| title | Possible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholics |
| title_full | Possible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholics |
| title_fullStr | Possible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholics |
| title_full_unstemmed | Possible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholics |
| title_short | Possible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholics |
| title_sort | possible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholics |
| topic | Steatosis Gastroenterology Internal medicine Cirrhosis Ascites Medicine Abstinence Necrosis Alcoholic liver disease Fibrosis Ethanol Jaundice Pathology Biology Psychiatry Biochemistry Steatosis Gastroenterology Internal medicine Cirrhosis Ascites Medicine Abstinence Necrosis Alcoholic liver disease Fibrosis Ethanol Jaundice Pathology Biology Psychiatry Adult Adult Adult Ethanol metabolism Ethanol metabolism Ethanol metabolism Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Biopsy Biopsy Biopsy Chronic Disease Chronic Disease Chronic Disease Fatty Liver metabolism Fatty Liver metabolism Fatty Liver metabolism Humans Humans Humans Liver pathology Liver pathology Liver pathology Liver Cirrhosis metabolism Liver Cirrhosis metabolism Liver Cirrhosis metabolism Liver Diseases metabolism Liver Diseases metabolism Liver Diseases metabolism Male Male Male Middle Aged Middle Aged Middle Aged Necrosis Necrosis Necrosis Chemical and Drug Induced Liver Injury metabolism Chemical and Drug Induced Liver Injury metabolism Chemical and Drug Induced Liver Injury metabolism Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Health Sciences Medicine Hepatology Liver Disease and Transplantation |
| topic_facet | Steatosis Gastroenterology Internal medicine Cirrhosis Ascites Medicine Abstinence Necrosis Alcoholic liver disease Fibrosis Ethanol Jaundice Pathology Biology Psychiatry Biochemistry Steatosis Gastroenterology Internal medicine Cirrhosis Ascites Medicine Abstinence Necrosis Alcoholic liver disease Fibrosis Ethanol Jaundice Pathology Biology Psychiatry Adult Adult Adult Ethanol metabolism Ethanol metabolism Ethanol metabolism Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Biopsy Biopsy Biopsy Chronic Disease Chronic Disease Chronic Disease Fatty Liver metabolism Fatty Liver metabolism Fatty Liver metabolism Humans Humans Humans Liver pathology Liver pathology Liver pathology Liver Cirrhosis metabolism Liver Cirrhosis metabolism Liver Cirrhosis metabolism Liver Diseases metabolism Liver Diseases metabolism Liver Diseases metabolism Male Male Male Middle Aged Middle Aged Middle Aged Necrosis Necrosis Necrosis Chemical and Drug Induced Liver Injury metabolism Chemical and Drug Induced Liver Injury metabolism Chemical and Drug Induced Liver Injury metabolism Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Health Sciences Medicine Hepatology Liver Disease and Transplantation |
| url | https://pubmed.ncbi.nlm.nih.gov/857661 https://hdl.handle.net/20.500.15037/1688 |
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