[Major histocompatibility system as a risk factor for alcoholic liver disease].
Several associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and change from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among Chil...
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
1995
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| _version_ | 1881508963358343168 |
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| author | Llop, Elena Hirsch, Sandra la Maza, de Bunout, Daniel Iturriaga, H Silva, C Vizcarra Ugarte, German Alex Rothhammer, Francisco |
| author_browse | Bunout, Daniel Hirsch, Sandra Iturriaga, H Llop, Elena Rothhammer, Francisco Silva, C Vizcarra Ugarte, German Alex la Maza, de |
| author_facet | Llop, Elena Hirsch, Sandra la Maza, de Bunout, Daniel Iturriaga, H Silva, C Vizcarra Ugarte, German Alex Rothhammer, Francisco |
| author_sort | Llop, Elena |
| collection | Producción científica |
| description | Several associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and change from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among Chilean alcoholics. We studied blood groups, serum proteins and HLA antigens in 39 alcoholic cirrhotics, 104 asymptomatic alcoholics and 44 non alcoholic controls. Asymptomatic alcoholics were also subjected to a percutaneous liver biopsy that showed moderate to severe histological liver damage in 46 subjects (44%). No differences in the studied genetic markers, were found among the four groups. It is concluded that this study does not confirm previously reported associations between genetic markers and alcoholic liver disease. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1660 |
| institution | UPeU |
| language | English |
| publishDate | 1995 |
| publishDateRange | 1995 |
| publishDateSort | 1995 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/16602026-10-30T16:16:24Z[Major histocompatibility system as a risk factor for alcoholic liver disease].Llop, ElenaHirsch, Sandrala Maza, deBunout, DanielIturriaga, HSilva, CVizcarra Ugarte, German AlexRothhammer, FranciscoAlcoholic liver diseaseAsymptomaticMedicineHuman leukocyte antigenHistocompatibilityPopulationDiseaseLiver diseaseAlleleRisk factorGastroenterologyLiver biopsyImmunologyInternal medicineBiopsyAntigenBiologyGeneGeneticsCirrhosisEnvironmental healthAdultAlcoholism geneticsChileGene FrequencyHLA Antigens bloodHLA Antigens classificationHumansLiver pathologyLiver Cirrhosis, Alcoholic geneticsLiver Cirrhosis, Alcoholic immunologyMajor Histocompatibility Complex geneticsMiddle AgedRisk FactorsCase-Control StudiesHealth Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health EffectsHealth Sciences Medicine Epidemiology Liver Disease Diagnosis and TreatmentSeveral associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and change from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among Chilean alcoholics. We studied blood groups, serum proteins and HLA antigens in 39 alcoholic cirrhotics, 104 asymptomatic alcoholics and 44 non alcoholic controls. Asymptomatic alcoholics were also subjected to a percutaneous liver biopsy that showed moderate to severe histological liver damage in 46 subjects (44%). No differences in the studied genetic markers, were found among the four groups. It is concluded that this study does not confirm previously reported associations between genetic markers and alcoholic liver disease.Articlehttps://pubmed.ncbi.nlm.nih.gov/8525220https://hdl.handle.net/20.500.15037/1660W2409255488enPubMed1995-06-012026-06-13T14:18:04Z2026-06-13T14:18:04Z |
| spellingShingle | Alcoholic liver disease Asymptomatic Medicine Human leukocyte antigen Histocompatibility Population Disease Liver disease Allele Risk factor Gastroenterology Liver biopsy Immunology Internal medicine Biopsy Antigen Biology Gene Genetics Cirrhosis Environmental health Adult Alcoholism genetics Chile Gene Frequency HLA Antigens blood HLA Antigens classification Humans Liver pathology Liver Cirrhosis, Alcoholic genetics Liver Cirrhosis, Alcoholic immunology Major Histocompatibility Complex genetics Middle Aged Risk Factors Case-Control Studies Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Llop, Elena Hirsch, Sandra la Maza, de Bunout, Daniel Iturriaga, H Silva, C Vizcarra Ugarte, German Alex Rothhammer, Francisco [Major histocompatibility system as a risk factor for alcoholic liver disease]. |
| title | [Major histocompatibility system as a risk factor for alcoholic liver disease]. |
| title_full | [Major histocompatibility system as a risk factor for alcoholic liver disease]. |
| title_fullStr | [Major histocompatibility system as a risk factor for alcoholic liver disease]. |
| title_full_unstemmed | [Major histocompatibility system as a risk factor for alcoholic liver disease]. |
| title_short | [Major histocompatibility system as a risk factor for alcoholic liver disease]. |
| title_sort | major histocompatibility system as a risk factor for alcoholic liver disease |
| topic | Alcoholic liver disease Asymptomatic Medicine Human leukocyte antigen Histocompatibility Population Disease Liver disease Allele Risk factor Gastroenterology Liver biopsy Immunology Internal medicine Biopsy Antigen Biology Gene Genetics Cirrhosis Environmental health Adult Alcoholism genetics Chile Gene Frequency HLA Antigens blood HLA Antigens classification Humans Liver pathology Liver Cirrhosis, Alcoholic genetics Liver Cirrhosis, Alcoholic immunology Major Histocompatibility Complex genetics Middle Aged Risk Factors Case-Control Studies Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment |
| topic_facet | Alcoholic liver disease Asymptomatic Medicine Human leukocyte antigen Histocompatibility Population Disease Liver disease Allele Risk factor Gastroenterology Liver biopsy Immunology Internal medicine Biopsy Antigen Biology Gene Genetics Cirrhosis Environmental health Adult Alcoholism genetics Chile Gene Frequency HLA Antigens blood HLA Antigens classification Humans Liver pathology Liver Cirrhosis, Alcoholic genetics Liver Cirrhosis, Alcoholic immunology Major Histocompatibility Complex genetics Middle Aged Risk Factors Case-Control Studies Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment |
| url | https://pubmed.ncbi.nlm.nih.gov/8525220 https://hdl.handle.net/20.500.15037/1660 |
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