[Major histocompatibility system as a risk factor for alcoholic liver disease].

Several associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and change from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among Chil...

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Guardado en:
Autores principales: Llop, Elena, Hirsch, Sandra, la Maza, de, Bunout, Daniel, Iturriaga, H, Silva, C, Vizcarra Ugarte, German Alex, Rothhammer, Francisco
Formato: Artículo
Lenguaje:inglés
Publicado: 1995
Materias:
Alcoholic liver disease
Asymptomatic
Medicine
Human leukocyte antigen
Histocompatibility
Population
Disease
Liver disease
Allele
Risk factor
Gastroenterology
Liver biopsy
Immunology
Internal medicine
Biopsy
Antigen
Biology
Gene
Genetics
Cirrhosis
Environmental health
Adult
Alcoholism genetics
Chile
Gene Frequency
HLA Antigens blood
HLA Antigens classification
Humans
Liver pathology
Liver Cirrhosis, Alcoholic genetics
Liver Cirrhosis, Alcoholic immunology
Major Histocompatibility Complex genetics
Middle Aged
Risk Factors
Case-Control Studies
Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects
Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment
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Sumario:Several associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and change from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among Chilean alcoholics. We studied blood groups, serum proteins and HLA antigens in 39 alcoholic cirrhotics, 104 asymptomatic alcoholics and 44 non alcoholic controls. Asymptomatic alcoholics were also subjected to a percutaneous liver biopsy that showed moderate to severe histological liver damage in 46 subjects (44%). No differences in the studied genetic markers, were found among the four groups. It is concluded that this study does not confirm previously reported associations between genetic markers and alcoholic liver disease.

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