Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent
Lung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in its early stages. The study of metabolic alterations after surgical intervention with curative intent could be used to as...
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| author | Saida Sánchez Espirilla Antonio Pereira‐Vega Belén Callejón‐Leblic Isabel Díaz-Olivares Rafael Santos Santana Carolina Gotera Rivera José Luis Gómez‐Ariza José Luís López-Campos Ana Isabel Blanco-Orozco Luis Seijó María Teresa Nava Rodríguez Luis Alejandro Padrón Fraysse Ángeles Herrera-Chilla Germán Peces‐Barba Tamara García‐Barrera |
| author_browse | Ana Isabel Blanco-Orozco Antonio Pereira‐Vega Belén Callejón‐Leblic Carolina Gotera Rivera Germán Peces‐Barba Isabel Díaz-Olivares José Luis Gómez‐Ariza José Luís López-Campos Luis Alejandro Padrón Fraysse Luis Seijó María Teresa Nava Rodríguez Rafael Santos Santana Saida Sánchez Espirilla Tamara García‐Barrera Ángeles Herrera-Chilla |
| author_facet | Saida Sánchez Espirilla Antonio Pereira‐Vega Belén Callejón‐Leblic Isabel Díaz-Olivares Rafael Santos Santana Carolina Gotera Rivera José Luis Gómez‐Ariza José Luís López-Campos Ana Isabel Blanco-Orozco Luis Seijó María Teresa Nava Rodríguez Luis Alejandro Padrón Fraysse Ángeles Herrera-Chilla Germán Peces‐Barba Tamara García‐Barrera |
| author_sort | Saida Sánchez Espirilla |
| collection | Producción científica |
| description | Lung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in its early stages. The study of metabolic alterations after surgical intervention with curative intent could be used to assess the response to treatment or the detection of cancer recurrence. In this study, we have evaluated the metabolomic profile of serum samples (n = 110) from preoperative (PRE) and postoperative (POST) LC patients collected at two different time points (1 month, A; 3–6 months, B) with respect to healthy people. An untargeted metabolomic platform based on reversed phase (RP) and hydrophilic interaction chromatography (HILIC), using ultra-high performance liquid chromatography (UHPLC) and mass spectrometry (MS), was applied (MassIVE ID MSV000092213). Twenty-two altered metabolites were annotated by comparing all the different studied groups. DG(14,0/22:1), stearamide, proline, and E,e-carotene-3,3′-dione were found altered in PRE, and their levels returned to those of a baseline control group 3–6 months after surgery. Furthermore, 3-galactosyllactose levels remained altered after intervention in some patients. This study provides unique insights into the metabolic profiles of LC patients after surgery at two different time points by combining complementary analytical methods. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1364 |
| institution | UPeU |
| language | English |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/13642026-10-30T16:15:39ZUntargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative IntentSaida Sánchez EspirillaAntonio Pereira‐VegaBelén Callejón‐LeblicIsabel Díaz-OlivaresRafael Santos SantanaCarolina Gotera RiveraJosé Luis Gómez‐ArizaJosé Luís López-CamposAna Isabel Blanco-OrozcoLuis SeijóMaría Teresa Nava RodríguezLuis Alejandro Padrón FraysseÁngeles Herrera-ChillaGermán Peces‐BarbaTamara García‐BarreraMetabolomicsLung cancerMedicineHydrophilic interaction chromatographyCancerInternal medicineGastroenterologySurgeryHigh-performance liquid chromatographyBioinformaticsChromatographyChemistryBiologyMetabolomicsLung cancerMedicineHydrophilic interaction chromatographyCancerInternal medicineGastroenterologySurgeryHigh-performance liquid chromatographyBioinformaticsChromatographyChemistryBiologyHumansHumansHumansLung Neoplasms diagnosisLung Neoplasms diagnosisLung Neoplasms diagnosisLung Neoplasms surgeryLung Neoplasms surgeryLung Neoplasms surgeryNeoplasm Recurrence, LocalNeoplasm Recurrence, LocalNeoplasm Recurrence, LocalMass Spectrometry methodsMass Spectrometry methodsMass Spectrometry methodsMetabolomics methodsMetabolomics methodsMetabolomics methodsMetabolomeMetabolomeMetabolomeLife Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Metabolomics and Mass Spectrometry StudiesLife Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Cancer, Hypoxia, and MetabolismLife Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Cancer, Lipids, and MetabolismLung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in its early stages. The study of metabolic alterations after surgical intervention with curative intent could be used to assess the response to treatment or the detection of cancer recurrence. In this study, we have evaluated the metabolomic profile of serum samples (n = 110) from preoperative (PRE) and postoperative (POST) LC patients collected at two different time points (1 month, A; 3–6 months, B) with respect to healthy people. An untargeted metabolomic platform based on reversed phase (RP) and hydrophilic interaction chromatography (HILIC), using ultra-high performance liquid chromatography (UHPLC) and mass spectrometry (MS), was applied (MassIVE ID MSV000092213). Twenty-two altered metabolites were annotated by comparing all the different studied groups. DG(14,0/22:1), stearamide, proline, and E,e-carotene-3,3′-dione were found altered in PRE, and their levels returned to those of a baseline control group 3–6 months after surgery. Furthermore, 3-galactosyllactose levels remained altered after intervention in some patients. This study provides unique insights into the metabolic profiles of LC patients after surgery at two different time points by combining complementary analytical methods.Articlehttps://pubmed.ncbi.nlm.nih.gov/37843028https://doi.org/10.1021/acs.jproteome.3c0035610.1021/acs.jproteome.3c00356https://hdl.handle.net/20.500.15037/1364W4387661325enJournal of Proteome Research1535-38931535-39072023-10-162026-06-13T09:55:37Z2026-06-13T09:55:37Z |
| spellingShingle | Metabolomics Lung cancer Medicine Hydrophilic interaction chromatography Cancer Internal medicine Gastroenterology Surgery High-performance liquid chromatography Bioinformatics Chromatography Chemistry Biology Metabolomics Lung cancer Medicine Hydrophilic interaction chromatography Cancer Internal medicine Gastroenterology Surgery High-performance liquid chromatography Bioinformatics Chromatography Chemistry Biology Humans Humans Humans Lung Neoplasms diagnosis Lung Neoplasms diagnosis Lung Neoplasms diagnosis Lung Neoplasms surgery Lung Neoplasms surgery Lung Neoplasms surgery Neoplasm Recurrence, Local Neoplasm Recurrence, Local Neoplasm Recurrence, Local Mass Spectrometry methods Mass Spectrometry methods Mass Spectrometry methods Metabolomics methods Metabolomics methods Metabolomics methods Metabolome Metabolome Metabolome Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Metabolomics and Mass Spectrometry Studies Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Cancer, Hypoxia, and Metabolism Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Cancer, Lipids, and Metabolism Saida Sánchez Espirilla Antonio Pereira‐Vega Belén Callejón‐Leblic Isabel Díaz-Olivares Rafael Santos Santana Carolina Gotera Rivera José Luis Gómez‐Ariza José Luís López-Campos Ana Isabel Blanco-Orozco Luis Seijó María Teresa Nava Rodríguez Luis Alejandro Padrón Fraysse Ángeles Herrera-Chilla Germán Peces‐Barba Tamara García‐Barrera Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent |
| title | Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent |
| title_full | Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent |
| title_fullStr | Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent |
| title_full_unstemmed | Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent |
| title_short | Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent |
| title_sort | untargeted metabolomic study of lung cancer patients after surgery with curative intent |
| topic | Metabolomics Lung cancer Medicine Hydrophilic interaction chromatography Cancer Internal medicine Gastroenterology Surgery High-performance liquid chromatography Bioinformatics Chromatography Chemistry Biology Metabolomics Lung cancer Medicine Hydrophilic interaction chromatography Cancer Internal medicine Gastroenterology Surgery High-performance liquid chromatography Bioinformatics Chromatography Chemistry Biology Humans Humans Humans Lung Neoplasms diagnosis Lung Neoplasms diagnosis Lung Neoplasms diagnosis Lung Neoplasms surgery Lung Neoplasms surgery Lung Neoplasms surgery Neoplasm Recurrence, Local Neoplasm Recurrence, Local Neoplasm Recurrence, Local Mass Spectrometry methods Mass Spectrometry methods Mass Spectrometry methods Metabolomics methods Metabolomics methods Metabolomics methods Metabolome Metabolome Metabolome Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Metabolomics and Mass Spectrometry Studies Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Cancer, Hypoxia, and Metabolism Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Cancer, Lipids, and Metabolism |
| topic_facet | Metabolomics Lung cancer Medicine Hydrophilic interaction chromatography Cancer Internal medicine Gastroenterology Surgery High-performance liquid chromatography Bioinformatics Chromatography Chemistry Biology Metabolomics Lung cancer Medicine Hydrophilic interaction chromatography Cancer Internal medicine Gastroenterology Surgery High-performance liquid chromatography Bioinformatics Chromatography Chemistry Biology Humans Humans Humans Lung Neoplasms diagnosis Lung Neoplasms diagnosis Lung Neoplasms diagnosis Lung Neoplasms surgery Lung Neoplasms surgery Lung Neoplasms surgery Neoplasm Recurrence, Local Neoplasm Recurrence, Local Neoplasm Recurrence, Local Mass Spectrometry methods Mass Spectrometry methods Mass Spectrometry methods Metabolomics methods Metabolomics methods Metabolomics methods Metabolome Metabolome Metabolome Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Metabolomics and Mass Spectrometry Studies Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Cancer, Hypoxia, and Metabolism Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Cancer, Lipids, and Metabolism |
| url | https://pubmed.ncbi.nlm.nih.gov/37843028 https://doi.org/10.1021/acs.jproteome.3c00356 https://hdl.handle.net/20.500.15037/1364 |
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