Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent

Lung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in its early stages. The study of metabolic alterations after surgical intervention with curative intent could be used to as...

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Autores principales: Saida Sánchez Espirilla, Antonio Pereira‐Vega, Belén Callejón‐Leblic, Isabel Díaz-Olivares, Rafael Santos Santana, Carolina Gotera Rivera, José Luis Gómez‐Ariza, José Luís López-Campos, Ana Isabel Blanco-Orozco, Luis Seijó, María Teresa Nava Rodríguez, Luis Alejandro Padrón Fraysse, Ángeles Herrera-Chilla, Germán Peces‐Barba, Tamara García‐Barrera
Formato: Artículo
Lenguaje:inglés
Publicado: 2023
Materias:
Metabolomics
Lung cancer
Medicine
Hydrophilic interaction chromatography
Cancer
Internal medicine
Gastroenterology
Surgery
High-performance liquid chromatography
Bioinformatics
Chromatography
Chemistry
Biology
Humans
Lung Neoplasms diagnosis
Lung Neoplasms surgery
Neoplasm Recurrence, Local
Mass Spectrometry methods
Metabolomics methods
Metabolome
Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Metabolomics and Mass Spectrometry Studies
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Cancer, Hypoxia, and Metabolism
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Cancer, Lipids, and Metabolism
Acceso en línea:Ver en el sistema de origen
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Sumario:Lung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in its early stages. The study of metabolic alterations after surgical intervention with curative intent could be used to assess the response to treatment or the detection of cancer recurrence. In this study, we have evaluated the metabolomic profile of serum samples (n = 110) from preoperative (PRE) and postoperative (POST) LC patients collected at two different time points (1 month, A; 3–6 months, B) with respect to healthy people. An untargeted metabolomic platform based on reversed phase (RP) and hydrophilic interaction chromatography (HILIC), using ultra-high performance liquid chromatography (UHPLC) and mass spectrometry (MS), was applied (MassIVE ID MSV000092213). Twenty-two altered metabolites were annotated by comparing all the different studied groups. DG(14,0/22:1), stearamide, proline, and E,e-carotene-3,3′-dione were found altered in PRE, and their levels returned to those of a baseline control group 3–6 months after surgery. Furthermore, 3-galactosyllactose levels remained altered after intervention in some patients. This study provides unique insights into the metabolic profiles of LC patients after surgery at two different time points by combining complementary analytical methods.

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