Characterizing trachoma elimination using serology

Trachoma is targeted for global elimination as a public health problem by 2030. Measurement of IgG antibodies in children is being considered for surveillance and programmatic decision-making. There are currently no programmatic guidelines based on serology, which represents a generalizable problem...

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Autores principales: Everlyn Kamau, Pearl Anne Ante-Testard, Sarah Gwyn, Seth Blumberg, Zeinab Abdalla, Kristen Aiemjoy, Abdou Amza, Solomon Aragie, Ahmed M. Arzika, Marcel S Awoussi, Robin L. Bailey, Robert Butcher, E. Kelly Callahan, David Chaima, Adisu Abebe Dawed, Martha Idalí Saboyá-Díaz, Abou-Bakr Sidik Domingo, Chris Drakeley, Belgesa E Elshafie, Paul M. Emerson, Kimberly Fornace, Katherine Gass, E. Brook Goodhew, Jaouad Hammou, Emma M. Harding‐Esch, PJ Hooper, Boubacar Kadri, Khumbo Kalua, Sarjo Kanyi, Mabula Kasubi, Amir Bedri Kello, Robert Ko, Patrick J. Lammie, Andrés G. Lescano, Ramatou Maliki, Michael Masika, Stephanie J Migchelsen, Beido Nassirou, John M. Nesemann, Nishanth Parameswaran, William Pomat, Kristen K. Renneker, Chrissy h. Roberts, Prudence Rymil, Eshetu Sata, Laura Senyonjo, Fikre Seife, Ansumana Sillah, Oliver Sokana, Ariktha Srivathsan, Zerihun Tadesse, Fasihah Taleo, Emma Michelle Taylor, Rabebe Tekeraoi, Kwamy Togbey, Sheila K. West, Karana Wickens, Timothy William, Dionna M. Wittberg, Dorothy Yeboah‐Manu, Mohammed Youbi, Tàye Zeru, Jeremy D. Keenan, Thomas M. Lietman, Anthony W. Solomon, Scott D. Nash, Diana L. Martin, Benjamin F. Arnold
Formato: Artículo
Lenguaje:inglés
Publicado: 2025
Materias:
Trachoma
Medicine
Seroconversion
Chlamydia trachomatis
Serology
Transmission (telecommunications)
Psychological intervention
Immunology
Environmental health
Antibody
Pathology
Computer science
Telecommunications
Psychiatry
Africa epidemiology
Antibodies, Bacterial blood
Antibodies, Bacterial immunology
Antigens, Bacterial
Bacterial Proteins
Child, Preschool
Chlamydia trachomatis immunology
Female
Humans
Immunoglobulin G blood
Immunoglobulin G immunology
Infant
Latin America epidemiology
Male
Trachoma blood
Trachoma immunology
Trachoma microbiology
Trachoma epidemiology
Trachoma prevention & control
Seroepidemiologic Studies
Disease Eradication
Life Sciences Immunology and Microbiology Microbiology Reproductive tract infections research
Health Sciences Medicine Epidemiology Cervical Cancer and HPV Research
Health Sciences Medicine Physiology Syphilis Diagnosis and Treatment
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Sumario:Trachoma is targeted for global elimination as a public health problem by 2030. Measurement of IgG antibodies in children is being considered for surveillance and programmatic decision-making. There are currently no programmatic guidelines based on serology, which represents a generalizable problem in seroepidemiology and disease elimination. Here, we collate Chlamydia trachomatis Pgp3 and CT694 IgG measurements from 48 serosurveys across Africa, Latin America, and the Pacific Islands (41,168 children ages 1-5 years) and propose a novel approach to estimate the probability that population C. trachomatis transmission is below or above levels requiring ongoing programmatic action. We determine that trachoma programs could halt control measures with >90% certainty when seroconversion rates (SCRs) are ≤2.2 per 100 person-years. Conversely, SCRs ≥4.5 per 100 person-years correspond with >90% certainty that further control interventions are needed. More extreme SCR thresholds correspond with higher levels of confidence of elimination (lower SCR) or ongoing action needed (higher SCR). This study demonstrates a robust approach for using trachoma serosurveys to guide elimination program decisions.

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