Utility of Individual Neurocognitive Domains of the Rowland Universal Dementia Assessment Scale to Detect Cognitive Impairment in an Urban Illiterate Population
INTRODUCTION: Brief cognitive tests like the RUDAS are useful for early detection of neurodegenerative diseases, especially in low-literacy populations in low- and middle-income countries. This study assesses the diagnostic performance of the RUDAS by subdomains to detect MCI and dementia in illiter...
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2025
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| author | Nilton Custodio Marco Málaga Diego Chambergo‐Michilot Rosa Montesinos Diego Bustamante‐Paytan Fiorella Baca Juan C. Carbajal-Silva José Carlos Huilca David Lira Junior Senador Eder Herrera‐Pérez Monica M. Diaz Serggio Lanata Jorge Alarcón |
| author_browse | David Lira Diego Bustamante‐Paytan Diego Chambergo‐Michilot Eder Herrera‐Pérez Fiorella Baca Jorge Alarcón José Carlos Huilca Juan C. Carbajal-Silva Junior Senador Marco Málaga Monica M. Diaz Nilton Custodio Rosa Montesinos Serggio Lanata |
| author_facet | Nilton Custodio Marco Málaga Diego Chambergo‐Michilot Rosa Montesinos Diego Bustamante‐Paytan Fiorella Baca Juan C. Carbajal-Silva José Carlos Huilca David Lira Junior Senador Eder Herrera‐Pérez Monica M. Diaz Serggio Lanata Jorge Alarcón |
| author_sort | Nilton Custodio |
| collection | Producción científica |
| description | INTRODUCTION: Brief cognitive tests like the RUDAS are useful for early detection of neurodegenerative diseases, especially in low-literacy populations in low- and middle-income countries. This study assesses the diagnostic performance of the RUDAS by subdomains to detect MCI and dementia in illiterate individuals in Lima, Peru. METHODS: We performed a secondary analysis of a cohort of randomly selected illiterate individuals, recruited for validation of RUDAS in Lima, Peru. We compared the RUDAS domain and total scores to a battery of neuropsychological tests (FDS, BDS, ROCF, MINT and Craft 21) using a Spearman correlation coefficient. For diagnostic performance, we calculated the area under the curve (AUC) for each RUDAS domain. RESULTS: We included 187 patients (64 controls, 60 MCI, and 63 dementia patients). Average RUDAS score was 23.87 ± 0.93, 20.43 ± 1.39, and 14.97 ± 2.21, respectively. Differences were statistically significant between groups for all domains, except for ideomotor praxis and visuo-spatial praxis. For convergent validity, most significant correlations from the bivariate analysis remained in the age-adjusted regression, particularly for praxis, memory, and judgment. The total RUDAS score had an AUC of 98% (95% CI: 96-100%) for both MCI and dementia, by domains, judgment, verbal fluency, and memory AUC ranging from 0.7 to 0.8. CONCLUSIONS: Our study showed the RUDAS domains of visuo-spatial orientation and memory had an excellent diagnostic performance for the detection of dementia. However, further research is needed to validate the use of individual RUDAS items for assessing specific cognitive domains. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1170 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/11702026-10-30T16:15:18ZUtility of Individual Neurocognitive Domains of the Rowland Universal Dementia Assessment Scale to Detect Cognitive Impairment in an Urban Illiterate PopulationNilton CustodioMarco MálagaDiego Chambergo‐MichilotRosa MontesinosDiego Bustamante‐PaytanFiorella BacaJuan C. Carbajal-SilvaJosé Carlos HuilcaDavid LiraJunior SenadorEder Herrera‐PérezMonica M. DiazSerggio LanataJorge AlarcónDementiaPsychologyPopulationNeuropsychologyCognitionNeurocognitiveCohortBivariate analysisVerbal fluency testClinical psychologyMedicinePsychiatryPathologyStatisticsDiseaseEnvironmental healthMathematicsDementiaPsychologyPopulationNeuropsychologyCognitionNeurocognitiveCohortBivariate analysisVerbal fluency testClinical psychologyMedicinePsychiatryPathologyStatisticsDiseaseLiteracyLiteracyMental Status and Dementia TestsMental Status and Dementia TestsAgedAgedAged, 80 and overAged, 80 and overDementia diagnosisDementia diagnosisDementia psychologyDementia psychologyFemaleFemaleHumansHumansMaleMaleMiddle AgedMiddle AgedNeuropsychological TestsNeuropsychological TestsPeruPeruUrban PopulationUrban PopulationReproducibility of ResultsReproducibility of ResultsCognitive Dysfunction diagnosisCognitive Dysfunction diagnosisCognitive Dysfunction psychologyCognitive Dysfunction psychologyHealth Sciences Medicine Psychiatry and Mental health Dementia and Cognitive Impairment ResearchHealth Sciences Health Professions Physical Therapy, Sports Therapy and Rehabilitation Older Adults Driving StudiesLife Sciences Neuroscience Cognitive Neuroscience Spatial Neglect and Hemispheric DysfunctionINTRODUCTION: Brief cognitive tests like the RUDAS are useful for early detection of neurodegenerative diseases, especially in low-literacy populations in low- and middle-income countries. This study assesses the diagnostic performance of the RUDAS by subdomains to detect MCI and dementia in illiterate individuals in Lima, Peru. METHODS: We performed a secondary analysis of a cohort of randomly selected illiterate individuals, recruited for validation of RUDAS in Lima, Peru. We compared the RUDAS domain and total scores to a battery of neuropsychological tests (FDS, BDS, ROCF, MINT and Craft 21) using a Spearman correlation coefficient. For diagnostic performance, we calculated the area under the curve (AUC) for each RUDAS domain. RESULTS: We included 187 patients (64 controls, 60 MCI, and 63 dementia patients). Average RUDAS score was 23.87 ± 0.93, 20.43 ± 1.39, and 14.97 ± 2.21, respectively. Differences were statistically significant between groups for all domains, except for ideomotor praxis and visuo-spatial praxis. For convergent validity, most significant correlations from the bivariate analysis remained in the age-adjusted regression, particularly for praxis, memory, and judgment. The total RUDAS score had an AUC of 98% (95% CI: 96-100%) for both MCI and dementia, by domains, judgment, verbal fluency, and memory AUC ranging from 0.7 to 0.8. CONCLUSIONS: Our study showed the RUDAS domains of visuo-spatial orientation and memory had an excellent diagnostic performance for the detection of dementia. However, further research is needed to validate the use of individual RUDAS items for assessing specific cognitive domains.Articlehttps://pubmed.ncbi.nlm.nih.gov/4060238110.1159/000546517https://hdl.handle.net/20.500.15037/1170W4411933003enDementia and Geriatric Cognitive Disorders1420-80081421-98242025-07-022026-06-13T09:48:34Z2026-06-13T09:48:34Z |
| spellingShingle | Dementia Psychology Population Neuropsychology Cognition Neurocognitive Cohort Bivariate analysis Verbal fluency test Clinical psychology Medicine Psychiatry Pathology Statistics Disease Environmental health Mathematics Dementia Psychology Population Neuropsychology Cognition Neurocognitive Cohort Bivariate analysis Verbal fluency test Clinical psychology Medicine Psychiatry Pathology Statistics Disease Literacy Literacy Mental Status and Dementia Tests Mental Status and Dementia Tests Aged Aged Aged, 80 and over Aged, 80 and over Dementia diagnosis Dementia diagnosis Dementia psychology Dementia psychology Female Female Humans Humans Male Male Middle Aged Middle Aged Neuropsychological Tests Neuropsychological Tests Peru Peru Urban Population Urban Population Reproducibility of Results Reproducibility of Results Cognitive Dysfunction diagnosis Cognitive Dysfunction diagnosis Cognitive Dysfunction psychology Cognitive Dysfunction psychology Health Sciences Medicine Psychiatry and Mental health Dementia and Cognitive Impairment Research Health Sciences Health Professions Physical Therapy, Sports Therapy and Rehabilitation Older Adults Driving Studies Life Sciences Neuroscience Cognitive Neuroscience Spatial Neglect and Hemispheric Dysfunction Nilton Custodio Marco Málaga Diego Chambergo‐Michilot Rosa Montesinos Diego Bustamante‐Paytan Fiorella Baca Juan C. Carbajal-Silva José Carlos Huilca David Lira Junior Senador Eder Herrera‐Pérez Monica M. Diaz Serggio Lanata Jorge Alarcón Utility of Individual Neurocognitive Domains of the Rowland Universal Dementia Assessment Scale to Detect Cognitive Impairment in an Urban Illiterate Population |
| title | Utility of Individual Neurocognitive Domains of the Rowland Universal Dementia Assessment Scale to Detect Cognitive Impairment in an Urban Illiterate Population |
| title_full | Utility of Individual Neurocognitive Domains of the Rowland Universal Dementia Assessment Scale to Detect Cognitive Impairment in an Urban Illiterate Population |
| title_fullStr | Utility of Individual Neurocognitive Domains of the Rowland Universal Dementia Assessment Scale to Detect Cognitive Impairment in an Urban Illiterate Population |
| title_full_unstemmed | Utility of Individual Neurocognitive Domains of the Rowland Universal Dementia Assessment Scale to Detect Cognitive Impairment in an Urban Illiterate Population |
| title_short | Utility of Individual Neurocognitive Domains of the Rowland Universal Dementia Assessment Scale to Detect Cognitive Impairment in an Urban Illiterate Population |
| title_sort | utility of individual neurocognitive domains of the rowland universal dementia assessment scale to detect cognitive impairment in an urban illiterate population |
| topic | Dementia Psychology Population Neuropsychology Cognition Neurocognitive Cohort Bivariate analysis Verbal fluency test Clinical psychology Medicine Psychiatry Pathology Statistics Disease Environmental health Mathematics Dementia Psychology Population Neuropsychology Cognition Neurocognitive Cohort Bivariate analysis Verbal fluency test Clinical psychology Medicine Psychiatry Pathology Statistics Disease Literacy Literacy Mental Status and Dementia Tests Mental Status and Dementia Tests Aged Aged Aged, 80 and over Aged, 80 and over Dementia diagnosis Dementia diagnosis Dementia psychology Dementia psychology Female Female Humans Humans Male Male Middle Aged Middle Aged Neuropsychological Tests Neuropsychological Tests Peru Peru Urban Population Urban Population Reproducibility of Results Reproducibility of Results Cognitive Dysfunction diagnosis Cognitive Dysfunction diagnosis Cognitive Dysfunction psychology Cognitive Dysfunction psychology Health Sciences Medicine Psychiatry and Mental health Dementia and Cognitive Impairment Research Health Sciences Health Professions Physical Therapy, Sports Therapy and Rehabilitation Older Adults Driving Studies Life Sciences Neuroscience Cognitive Neuroscience Spatial Neglect and Hemispheric Dysfunction |
| topic_facet | Dementia Psychology Population Neuropsychology Cognition Neurocognitive Cohort Bivariate analysis Verbal fluency test Clinical psychology Medicine Psychiatry Pathology Statistics Disease Environmental health Mathematics Dementia Psychology Population Neuropsychology Cognition Neurocognitive Cohort Bivariate analysis Verbal fluency test Clinical psychology Medicine Psychiatry Pathology Statistics Disease Literacy Literacy Mental Status and Dementia Tests Mental Status and Dementia Tests Aged Aged Aged, 80 and over Aged, 80 and over Dementia diagnosis Dementia diagnosis Dementia psychology Dementia psychology Female Female Humans Humans Male Male Middle Aged Middle Aged Neuropsychological Tests Neuropsychological Tests Peru Peru Urban Population Urban Population Reproducibility of Results Reproducibility of Results Cognitive Dysfunction diagnosis Cognitive Dysfunction diagnosis Cognitive Dysfunction psychology Cognitive Dysfunction psychology Health Sciences Medicine Psychiatry and Mental health Dementia and Cognitive Impairment Research Health Sciences Health Professions Physical Therapy, Sports Therapy and Rehabilitation Older Adults Driving Studies Life Sciences Neuroscience Cognitive Neuroscience Spatial Neglect and Hemispheric Dysfunction |
| url | https://pubmed.ncbi.nlm.nih.gov/40602381 https://hdl.handle.net/20.500.15037/1170 |
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