Detección de virus influenza A, B y subtipos A (H1N1) pdm09, A (H3N2) por múltiple RT-PCR en muestras clínicas

OBJECTIVES.: To describe the clinical and epidemiological characteristics of patients diagnosed with epidermolysis bullosa (EB) at the Instituto Nacional de Salud (INSN) in Lima, Peru; a National Reference Center for this disease. MATERIAL AND METHODS: . Observational, descriptive and transversal st...

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Autores principales: Pool Marcos-Carbajal, Maribel Huaringa, Nancy Rojas, Victoria Gutiérrez, Sila Ruiton, Emelda Gallardo, Jorge Achata, Marco Galarza
Formato: Artículo
Lenguaje:español
Publicado: 2017
Materias:
Medicine
Malnutrition
Epidemiology
Internal medicine
Dermatology
Epidermolysis bullosa
Pediatrics
Gastroenterology
Adolescent
Cross-Sectional Studies
Female
Humans
Influenza, Human virology
Male
Haemophilus influenzae type b isolation & purification
Influenza A Virus, H1N1 Subtype isolation & purification
Influenza A Virus, H3N2 Subtype isolation & purification
Real-Time Polymerase Chain Reaction
Life Sciences Immunology and Microbiology Virology Poxvirus research and outbreaks
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology Skin and Cellular Biology Research
Health Sciences Medicine Physiology Syphilis Diagnosis and Treatment
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Sumario:OBJECTIVES.: To describe the clinical and epidemiological characteristics of patients diagnosed with epidermolysis bullosa (EB) at the Instituto Nacional de Salud (INSN) in Lima, Peru; a National Reference Center for this disease. MATERIAL AND METHODS: . Observational, descriptive and transversal study. We reviewed the clinical histories and laboratory tests of patients diagnosed with EB treated in INSN from 1993 to 2015. RESULTS.: 93 patients were registered. The average age was 7.9 ± 5.6 years; 53.8% (n = 50) were boys. Clinical forms corresponded to dystrophic EB with 41 (44.1%) cases, simple EB with 39 (41.9%) union EB cases with 8 (8.6%) and Kindler syndrome with 4 (4.3%) cases. The clinical form could not be identified in a case. A total of 48 cases (51.6%) came from Lima and Callao, and 45 cases (48.4%) from other provinces of the country. Extracutaneous manifestations involved gastrointestinal (44.1%), ocular (37.6%), odontogenic (87.1%), and nutritional (79.6%) involvement, as well as pseudosindactilia (16.1%). Chronic malnutrition (71.6%), acute malnutrition (17.6%) and anemia (62.4%) were found. Mortality corresponded to 6 cases (6.5%). CONCLUSIONS.: 93 cases of EB were reported in INSN, the predominant clinical presentation was the dystrophic form.

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