Emergence of carbapenem-resistant Pseudomonas aeruginosa ST179 producing both IMP-16 and KPC-2: a case study of introduction from Peru to Spain

ABSTRACT We describe four cases of a novel carbapenem-resistant Pseudomonas aeruginosa ST179 clone carrying the bla KPC-2 or bla KPC-35 gene together with bla IMP-16 , imported from Peru to Spain and isolated from leukemia patients. All isolates were multidrug-resistant but remained susceptible to f...

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Autores principales: Joaquim Viñes, Carlos Lopera, Andrea Vergara, Ignasi Roca, Jordi Vilà, Climent Casals‐Pascual, José Antonio Martínez, Carolina García‐Vidal, Àlex Soriano, Cristina Pitart
Formato: Artículo
Lenguaje:inglés
Publicado: 2024
Materias:
Pseudomonas aeruginosa
Carbapenem
Microbiology
Biology
Bacteria
Genetics
Antibiotics
Whole Genome Sequencing
Adult
Anti-Bacterial Agents pharmacology
Bacterial Proteins genetics
Bacterial Proteins metabolism
beta-Lactamases genetics
beta-Lactamases metabolism
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Peru
Plasmids genetics
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa enzymology
Pseudomonas aeruginosa genetics
Pseudomonas aeruginosa isolation & purification
Pseudomonas Infections microbiology
Spain
Carbapenems pharmacology
Drug Resistance, Multiple, Bacterial genetics
Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Medicine Antibiotic Resistance in Bacteria
Life Sciences Immunology and Microbiology Applied Microbiology and Biotechnology Antibiotic Use and Resistance
Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Bacterial biofilms and quorum sensing
Acceso en línea:Ver en el sistema de origen
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Sumario:ABSTRACT We describe four cases of a novel carbapenem-resistant Pseudomonas aeruginosa ST179 clone carrying the bla KPC-2 or bla KPC-35 gene together with bla IMP-16 , imported from Peru to Spain and isolated from leukemia patients. All isolates were multidrug-resistant but remained susceptible to fosfomycin, cefiderocol, and colistin. Whole-genome sequencing revealed that bla KPC-2 and bla KPC-35 were located in an IncP6 plasmid, whereas bla IMP-16 was in a chromosomal type 1 integron. This study highlights the global threat of multidrug-resistant P. aeruginosa clones and underscores the importance of monitoring and early detection of emerging resistance mechanisms to guide appropriate treatment strategies. The importation and spread of such clones emphasize the urgent need to implement strict infection control measures to prevent the dissemination of carbapenem-resistant bacteria. IMPORTANCE This is the first documented case of a Pseudomonas aeruginosa ST179 strain carrying the blaKPC-35 gene, and it represents the first report of a P. aeruginosa co-harboring blaIMP-16 and either blaKPC-2 or blaKPC-35, which wre imported from Peru to Spain, highlighting a threat due to the capacity of spreading carbapenem-resistance via plasmid conjugation.

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