Disparities in treatment burden in Peru among people with multiple long-term conditions by geography and healthcare facility: A cross-sectional study

People with multiple long-term conditions (MLTC) in low-resource settings face high treatment burdens, influenced by healthcare access and quality disparities. The study aimed to compare the treatment burden among patients with MLTC across geographical locations and healthcare providers in Peru. We...

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Autores principales: Silvana Pérez-León, Daniel Mendoza‐Quispe, María Sofía Cuba-Fuentes, Juan Carlos Bazo‐Alvarez, María Amalia Pesantes, Andrea Gaspar, Joseph Raymond Zunt, Víctor M. Montori, Jose A. Castillo, Eduardo Carcausto, Nelson Diaz, Keveen Steve Salirrosas Flores, Pilar Cornejo, J. Jaime Miranda
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Publicado: 2026
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author Silvana Pérez-León
Daniel Mendoza‐Quispe
María Sofía Cuba-Fuentes
Juan Carlos Bazo‐Alvarez
María Amalia Pesantes
Andrea Gaspar
Joseph Raymond Zunt
Víctor M. Montori
Jose A. Castillo
Eduardo Carcausto
Nelson Diaz
Keveen Steve Salirrosas Flores
Pilar Cornejo
J. Jaime Miranda
author_browse Andrea Gaspar
Daniel Mendoza‐Quispe
Eduardo Carcausto
J. Jaime Miranda
Jose A. Castillo
Joseph Raymond Zunt
Juan Carlos Bazo‐Alvarez
Keveen Steve Salirrosas Flores
María Amalia Pesantes
María Sofía Cuba-Fuentes
Nelson Diaz
Pilar Cornejo
Silvana Pérez-León
Víctor M. Montori
author_facet Silvana Pérez-León
Daniel Mendoza‐Quispe
María Sofía Cuba-Fuentes
Juan Carlos Bazo‐Alvarez
María Amalia Pesantes
Andrea Gaspar
Joseph Raymond Zunt
Víctor M. Montori
Jose A. Castillo
Eduardo Carcausto
Nelson Diaz
Keveen Steve Salirrosas Flores
Pilar Cornejo
J. Jaime Miranda
author_sort Silvana Pérez-León
collection Producción científica
description People with multiple long-term conditions (MLTC) in low-resource settings face high treatment burdens, influenced by healthcare access and quality disparities. The study aimed to compare the treatment burden among patients with MLTC across geographical locations and healthcare providers in Peru. We conducted a cross-sectional study conducted between June-October 2023 among outpatients aged ≥40 years with type 2 diabetes and ≥1 additional chronic condition, recruited from public and private healthcare facilities in urban Lima and semi-urban Tumbes, Peru. Treatment burden was assessed using the Multimorbidity Treatment Burden Questionnaire (MTBQ). Differences in median MTBQ scores by setting and healthcare provider were analyzed using regression models adjusting for capacity- and workload-related variables. Among 555 participants (55% female, mean age 62.4 ± 10.5 years), median MTBQ score was 27.1 (IQR 14.6-41.7). After adjustment, patients in semi-urban Tumbes had higher treatment burden than those in urban Lima (adjusted median difference 6.1 points; 95% CI 2.9 to 9.3), while patients receiving care in private facilities had lower treatment burden than those in public settings (-6.6 points; 95% CI -9.3 to -3.9). These findings highlight substantial inequalities in treatment burden by place and provider type, with implications for efforts to improve care delivery and reduce disparities for people living with MLTC.
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spelling openalex:W7214742996Disparities in treatment burden in Peru among people with multiple long-term conditions by geography and healthcare facility: A cross-sectional studySilvana Pérez-LeónDaniel Mendoza‐QuispeMaría Sofía Cuba-FuentesJuan Carlos Bazo‐AlvarezMaría Amalia PesantesAndrea GasparJoseph Raymond ZuntVíctor M. MontoriJose A. CastilloEduardo CarcaustoNelson DiazKeveen Steve Salirrosas FloresPilar CornejoJ. Jaime Mirandamultimorbiditytreatment burdentype 2 diabeteschronic diseasehealth care disparitiesurban-rural differenceshealth care accessquality of carePeruLimaTumbesChronic Disease Management StrategiesPharmaceutical Practices and Patient OutcomesDiabetes Management and EducationPeople with multiple long-term conditions (MLTC) in low-resource settings face high treatment burdens, influenced by healthcare access and quality disparities. The study aimed to compare the treatment burden among patients with MLTC across geographical locations and healthcare providers in Peru. We conducted a cross-sectional study conducted between June-October 2023 among outpatients aged ≥40 years with type 2 diabetes and ≥1 additional chronic condition, recruited from public and private healthcare facilities in urban Lima and semi-urban Tumbes, Peru. Treatment burden was assessed using the Multimorbidity Treatment Burden Questionnaire (MTBQ). Differences in median MTBQ scores by setting and healthcare provider were analyzed using regression models adjusting for capacity- and workload-related variables. Among 555 participants (55% female, mean age 62.4 ± 10.5 years), median MTBQ score was 27.1 (IQR 14.6-41.7). After adjustment, patients in semi-urban Tumbes had higher treatment burden than those in urban Lima (adjusted median difference 6.1 points; 95% CI 2.9 to 9.3), while patients receiving care in private facilities had lower treatment burden than those in public settings (-6.6 points; 95% CI -9.3 to -3.9). These findings highlight substantial inequalities in treatment burden by place and provider type, with implications for efforts to improve care delivery and reduce disparities for people living with MLTC.Articlehttps://doi.org/10.1371/journal.pgph.0007355https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0007355&type=printableW7214742996enPLOS Global Public Health2767-33752026-09-29
spellingShingle multimorbidity
treatment burden
type 2 diabetes
chronic disease
health care disparities
urban-rural differences
health care access
quality of care
Peru
Lima
Tumbes
Chronic Disease Management Strategies
Pharmaceutical Practices and Patient Outcomes
Diabetes Management and Education
Silvana Pérez-León
Daniel Mendoza‐Quispe
María Sofía Cuba-Fuentes
Juan Carlos Bazo‐Alvarez
María Amalia Pesantes
Andrea Gaspar
Joseph Raymond Zunt
Víctor M. Montori
Jose A. Castillo
Eduardo Carcausto
Nelson Diaz
Keveen Steve Salirrosas Flores
Pilar Cornejo
J. Jaime Miranda
Disparities in treatment burden in Peru among people with multiple long-term conditions by geography and healthcare facility: A cross-sectional study
title Disparities in treatment burden in Peru among people with multiple long-term conditions by geography and healthcare facility: A cross-sectional study
title_full Disparities in treatment burden in Peru among people with multiple long-term conditions by geography and healthcare facility: A cross-sectional study
title_fullStr Disparities in treatment burden in Peru among people with multiple long-term conditions by geography and healthcare facility: A cross-sectional study
title_full_unstemmed Disparities in treatment burden in Peru among people with multiple long-term conditions by geography and healthcare facility: A cross-sectional study
title_short Disparities in treatment burden in Peru among people with multiple long-term conditions by geography and healthcare facility: A cross-sectional study
title_sort disparities in treatment burden in peru among people with multiple long term conditions by geography and healthcare facility a cross sectional study
topic multimorbidity
treatment burden
type 2 diabetes
chronic disease
health care disparities
urban-rural differences
health care access
quality of care
Peru
Lima
Tumbes
Chronic Disease Management Strategies
Pharmaceutical Practices and Patient Outcomes
Diabetes Management and Education
topic_facet multimorbidity
treatment burden
type 2 diabetes
chronic disease
health care disparities
urban-rural differences
health care access
quality of care
Peru
Lima
Tumbes
Chronic Disease Management Strategies
Pharmaceutical Practices and Patient Outcomes
Diabetes Management and Education
url https://doi.org/10.1371/journal.pgph.0007355
https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0007355&type=printable
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