Efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin and anemia in the pediatric population: A systematic review and meta-analysis
AIM: To evaluate the efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin levels and anemia in the pediatric population. METHODS: We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs). PubMed, Embase, and CENTRAL were searched up to August 202...
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| Formato: | Artículo de revisión |
| Lenguaje: | inglés |
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2026
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| author | Gladys Estheysi Elías Solís Steffi Aleksandra Maraza Pacori Salomón Huancahuire‐Vega David R. Soriano‐Moreno |
| author_browse | David R. Soriano‐Moreno Gladys Estheysi Elías Solís Salomón Huancahuire‐Vega Steffi Aleksandra Maraza Pacori |
| author_facet | Gladys Estheysi Elías Solís Steffi Aleksandra Maraza Pacori Salomón Huancahuire‐Vega David R. Soriano‐Moreno |
| author_sort | Gladys Estheysi Elías Solís |
| collection | Producción científica |
| description | AIM: To evaluate the efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin levels and anemia in the pediatric population. METHODS: We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs). PubMed, Embase, and CENTRAL were searched up to August 2025. We included RCTs assessing prebiotics, probiotics, or synbiotics on hemoglobin or anemia in children. Random-effects meta-analyses were performed, and certainty of evidence was assessed using GRADE and minimal important differences. The protocol was registered in PROSPERO (CRD420251108276). RESULTS: Nineteen RCTs involving 4188 children were included. Compared to placebo or standard care, prebiotics, probiotics, and synbiotics (alone or with iron) showed no important effects on hemoglobin, hematocrit, or ferritin (certainty: high to very low). However, probiotics versus placebo may reduce anemia (1 RCT; RD: --6 per 100; 95% CI: --15 to +6, low certainty). No serious adverse events were reported; observed events were mainly mild gastrointestinal symptoms. CONCLUSION: Prebiotics, probiotics, and synbiotics do not provide clinically important benefits on hemoglobin or anemia in children, although they appear safe. Larger, high-quality trials in high-risk populations are needed. |
| format | Review |
| id | openalex:W7171668717 |
| institution | UPeU |
| language | English |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| record_format | dspace |
| spelling | openalex:W7171668717Efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin and anemia in the pediatric population: A systematic review and meta-analysisGladys Estheysi Elías SolísSteffi Aleksandra Maraza PacoriSalomón Huancahuire‐VegaDavid R. Soriano‐Morenoprebioticsprobioticssynbioticsanemiahemoglobinchildreniron supplementationferritinhematocritgastrointestinal adverse effectsProbiotics and Fermented FoodsInfant Nutrition and HealthIron Metabolism and DisordersAIM: To evaluate the efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin levels and anemia in the pediatric population. METHODS: We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs). PubMed, Embase, and CENTRAL were searched up to August 2025. We included RCTs assessing prebiotics, probiotics, or synbiotics on hemoglobin or anemia in children. Random-effects meta-analyses were performed, and certainty of evidence was assessed using GRADE and minimal important differences. The protocol was registered in PROSPERO (CRD420251108276). RESULTS: Nineteen RCTs involving 4188 children were included. Compared to placebo or standard care, prebiotics, probiotics, and synbiotics (alone or with iron) showed no important effects on hemoglobin, hematocrit, or ferritin (certainty: high to very low). However, probiotics versus placebo may reduce anemia (1 RCT; RD: --6 per 100; 95% CI: --15 to +6, low certainty). No serious adverse events were reported; observed events were mainly mild gastrointestinal symptoms. CONCLUSION: Prebiotics, probiotics, and synbiotics do not provide clinically important benefits on hemoglobin or anemia in children, although they appear safe. Larger, high-quality trials in high-risk populations are needed.Reviewhttps://doi.org/10.1371/journal.pone.0354681https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0354681&type=printableW7171668717enPLoS ONE1932-62032026-07-29 |
| spellingShingle | prebiotics probiotics synbiotics anemia hemoglobin children iron supplementation ferritin hematocrit gastrointestinal adverse effects Probiotics and Fermented Foods Infant Nutrition and Health Iron Metabolism and Disorders Gladys Estheysi Elías Solís Steffi Aleksandra Maraza Pacori Salomón Huancahuire‐Vega David R. Soriano‐Moreno Efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin and anemia in the pediatric population: A systematic review and meta-analysis |
| title | Efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin and anemia in the pediatric population: A systematic review and meta-analysis |
| title_full | Efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin and anemia in the pediatric population: A systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin and anemia in the pediatric population: A systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin and anemia in the pediatric population: A systematic review and meta-analysis |
| title_short | Efficacy and safety of prebiotics, probiotics, and synbiotics on hemoglobin and anemia in the pediatric population: A systematic review and meta-analysis |
| title_sort | efficacy and safety of prebiotics probiotics and synbiotics on hemoglobin and anemia in the pediatric population a systematic review and meta analysis |
| topic | prebiotics probiotics synbiotics anemia hemoglobin children iron supplementation ferritin hematocrit gastrointestinal adverse effects Probiotics and Fermented Foods Infant Nutrition and Health Iron Metabolism and Disorders |
| topic_facet | prebiotics probiotics synbiotics anemia hemoglobin children iron supplementation ferritin hematocrit gastrointestinal adverse effects Probiotics and Fermented Foods Infant Nutrition and Health Iron Metabolism and Disorders |
| url | https://doi.org/10.1371/journal.pone.0354681 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0354681&type=printable |
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