Neuroplasticity and recovery of the brain affected by substance use disorder: multilevel mechanisms and new therapeutic strategies (2020–2025)

Introduction: Substance use disorder (SUD) is a complex neurobiological disorder characterized by the consolidation of maladaptive neuroplasticity affecting dopaminergic, glutamatergic, and neurotrophic systems, as well as cortical and subcortical networks critical for executive control, emotional r...

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Autores principales: Roberto Estrada-Medina, Berle Estalin Briones-Llamoctanta, Josue Edison Turpo-Chaparro
Formato: Artículo de revisión
Lenguaje:inglés
Publicado: 2026
Materias:
substance use disorders
neuroplasticity
brain recovery
synaptic plasticity
BDNF/TrkB signaling
epigenetic regulation
prefrontal cortex
nucleus accumbens
amygdala
neuromodulation
repetitive transcranial magnetic stimulation
transcranial direct current stimulation
deep brain stimulation
memory reconsolidation
craving
neurotrophic signaling
anti-inflammatory therapy
neurobiological biomarkers
Neurotransmitter Receptor Influence on Behavior
Substance Abuse Treatment and Outcomes
Neuroscience and Neuropharmacology Research
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Internet

https://doi.org/10.3389/fnmol.2026.1760387
https://public-pages-files-2025.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2026.1760387/pdf

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