Neuroplasticity and recovery of the brain affected by substance use disorder: multilevel mechanisms and new therapeutic strategies (2020–2025)

Introduction: Substance use disorder (SUD) is a complex neurobiological disorder characterized by the consolidation of maladaptive neuroplasticity affecting dopaminergic, glutamatergic, and neurotrophic systems, as well as cortical and subcortical networks critical for executive control, emotional r...

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Autores principales:	Roberto Estrada-Medina, Berle Estalin Briones-Llamoctanta, Josue Edison Turpo-Chaparro
Formato:	Artículo de revisión
Lenguaje:	inglés
Publicado:	2026
Materias:	substance use disorders neuroplasticity brain recovery synaptic plasticity BDNF/TrkB signaling epigenetic regulation prefrontal cortex nucleus accumbens amygdala neuromodulation repetitive transcranial magnetic stimulation transcranial direct current stimulation deep brain stimulation memory reconsolidation craving neurotrophic signaling anti-inflammatory therapy neurobiological biomarkers Neurotransmitter Receptor Influence on Behavior Substance Abuse Treatment and Outcomes Neuroscience and Neuropharmacology Research
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