P-1667. Clinical, Laboratory, and Antimicrobial Resistance Patterns in Patients with Diabetic Foot Ulcers during the COVID-19 Pandemic in a Tertiary Care Hospital in Lima, Peru
Abstract Background Diabetic foot ulcer (DFU) is a serious complication of type 2 diabetes mellitus (T2DM), often resulting in infection and amputation. During the COVID-19 lockdown, reduced healthcare access delayed diagnosis and worsened glycemic control, increasing DFU incidence and severity. Ant...
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| Formato: | Conference abstract |
| Lenguaje: | inglés |
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2026
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| author | Victor Llontop-Silva Camila A. Arones-Santayana Sebastian A. Medina-Ramírez Guiliana Mas-Ubillus Carolina Sarria Arenaza |
| author_browse | Camila A. Arones-Santayana Carolina Sarria Arenaza Guiliana Mas-Ubillus Sebastian A. Medina-Ramírez Victor Llontop-Silva |
| author_facet | Victor Llontop-Silva Camila A. Arones-Santayana Sebastian A. Medina-Ramírez Guiliana Mas-Ubillus Carolina Sarria Arenaza |
| author_sort | Victor Llontop-Silva |
| collection | Producción científica |
| description | Abstract Background Diabetic foot ulcer (DFU) is a serious complication of type 2 diabetes mellitus (T2DM), often resulting in infection and amputation. During the COVID-19 lockdown, reduced healthcare access delayed diagnosis and worsened glycemic control, increasing DFU incidence and severity. Antimicrobial resistance adds to the challenge; understanding microbial profiles and resistance patterns is essential for effective treatment. This study describes the clinical and laboratory features of T2DM patients with infected DFUs during the pandemic and evaluates their microbiological and resistance profiles. Methods We conducted a cross-sectional, observational, and retrospective study at Hospital Nacional Arzobispo Loayza, including adult T2DM patients with infected DFU hospitalized in the emergency department between January 2020 and December 2022. Data were extracted from patients' medical records. Results We included 237 patients. The mean age was 61 ± 10.3 years; 64.1% were male. Median glycated hemoglobin was 10.3% [IQR 7.9–12.2]. 68.4% had no history of prior DFU. Wagner grade IV was observed in 150 patients (63.6%). Ulcers > 4 cm were seen in 42.7%. Surgical debridement was performed in 48.7%, and amputation or toe disarticulation in 51.3%. Cultures were obtained in only 14.3% of patients. 55.4% of which were Gram-negative and 35% of these patients had a polymicrobial infection. The most frequent Gram-positive and negative isolates were S. aureus, E. faecalis, and E. coli. Gram-positive organisms showed high resistance to erythromycin (66.6%), tetracycline and clindamycin (52.3%), benzylpenicillin (47.6%), and oxacillin (42.8%). Among Gram-negative isolates, resistance rates were highest for ciprofloxacin (84.6%), cefazolin (73%), ceftazidime (57.7%), and both ceftriaxone and cefepime (50%). MRSA accounted for 71.4% of S. aureus isolates. ESBL producers comprised 57.7% of Gram-negatives, predominantly K. pneumoniae (85.7%) and E. coli (40%), with E. coli showing 70% resistance to ciprofloxacin and 40% to gentamicin. Conclusion Poor glycemic control, young age, and high amputation rates reflect DFU severity during the pandemic. Despite low culture rates, high antimicrobial resistance highlights the need for routine sampling and surveillance. Disclosures All Authors: No reported disclosures |
| format | Conference abstract |
| id | openalex:W7122852374 |
| institution | UPeU |
| language | English |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| record_format | dspace |
| spelling | openalex:W7122852374P-1667. Clinical, Laboratory, and Antimicrobial Resistance Patterns in Patients with Diabetic Foot Ulcers during the COVID-19 Pandemic in a Tertiary Care Hospital in Lima, PeruVictor Llontop-SilvaCamila A. Arones-SantayanaSebastian A. Medina-RamírezGuiliana Mas-UbillusCarolina Sarria Arenazadiabetic foot ulcertype 2 diabetesCOVID-19 pandemicantimicrobial resistancemethicillin-resistant Staphylococcus aureusextended-spectrum beta-lactamaseco-infectionGram-negative bacteriaStaphylococcus aureusEscherichia faecalisEscherichia colisurgical debridementamputationglycemic controlWagner gradeLimaemergency departmentDiabetic Foot Ulcer Assessment and ManagementAntibiotic Use and ResistanceOrthopedic Infections and TreatmentsAbstract Background Diabetic foot ulcer (DFU) is a serious complication of type 2 diabetes mellitus (T2DM), often resulting in infection and amputation. During the COVID-19 lockdown, reduced healthcare access delayed diagnosis and worsened glycemic control, increasing DFU incidence and severity. Antimicrobial resistance adds to the challenge; understanding microbial profiles and resistance patterns is essential for effective treatment. This study describes the clinical and laboratory features of T2DM patients with infected DFUs during the pandemic and evaluates their microbiological and resistance profiles. Methods We conducted a cross-sectional, observational, and retrospective study at Hospital Nacional Arzobispo Loayza, including adult T2DM patients with infected DFU hospitalized in the emergency department between January 2020 and December 2022. Data were extracted from patients' medical records. Results We included 237 patients. The mean age was 61 ± 10.3 years; 64.1% were male. Median glycated hemoglobin was 10.3% [IQR 7.9–12.2]. 68.4% had no history of prior DFU. Wagner grade IV was observed in 150 patients (63.6%). Ulcers > 4 cm were seen in 42.7%. Surgical debridement was performed in 48.7%, and amputation or toe disarticulation in 51.3%. Cultures were obtained in only 14.3% of patients. 55.4% of which were Gram-negative and 35% of these patients had a polymicrobial infection. The most frequent Gram-positive and negative isolates were S. aureus, E. faecalis, and E. coli. Gram-positive organisms showed high resistance to erythromycin (66.6%), tetracycline and clindamycin (52.3%), benzylpenicillin (47.6%), and oxacillin (42.8%). Among Gram-negative isolates, resistance rates were highest for ciprofloxacin (84.6%), cefazolin (73%), ceftazidime (57.7%), and both ceftriaxone and cefepime (50%). MRSA accounted for 71.4% of S. aureus isolates. ESBL producers comprised 57.7% of Gram-negatives, predominantly K. pneumoniae (85.7%) and E. coli (40%), with E. coli showing 70% resistance to ciprofloxacin and 40% to gentamicin. Conclusion Poor glycemic control, young age, and high amputation rates reflect DFU severity during the pandemic. Despite low culture rates, high antimicrobial resistance highlights the need for routine sampling and surveillance. Disclosures All Authors: No reported disclosuresConference abstracthttps://doi.org/10.1093/ofid/ofaf695.1841W7122852374enOpen Forum Infectious Diseases2328-89572026-01-01 |
| spellingShingle | diabetic foot ulcer type 2 diabetes COVID-19 pandemic antimicrobial resistance methicillin-resistant Staphylococcus aureus extended-spectrum beta-lactamase co-infection Gram-negative bacteria Staphylococcus aureus Escherichia faecalis Escherichia coli surgical debridement amputation glycemic control Wagner grade Lima emergency department Diabetic Foot Ulcer Assessment and Management Antibiotic Use and Resistance Orthopedic Infections and Treatments Victor Llontop-Silva Camila A. Arones-Santayana Sebastian A. Medina-Ramírez Guiliana Mas-Ubillus Carolina Sarria Arenaza P-1667. Clinical, Laboratory, and Antimicrobial Resistance Patterns in Patients with Diabetic Foot Ulcers during the COVID-19 Pandemic in a Tertiary Care Hospital in Lima, Peru |
| title | P-1667. Clinical, Laboratory, and Antimicrobial Resistance Patterns in Patients with Diabetic Foot Ulcers during the COVID-19 Pandemic in a Tertiary Care Hospital in Lima, Peru |
| title_full | P-1667. Clinical, Laboratory, and Antimicrobial Resistance Patterns in Patients with Diabetic Foot Ulcers during the COVID-19 Pandemic in a Tertiary Care Hospital in Lima, Peru |
| title_fullStr | P-1667. Clinical, Laboratory, and Antimicrobial Resistance Patterns in Patients with Diabetic Foot Ulcers during the COVID-19 Pandemic in a Tertiary Care Hospital in Lima, Peru |
| title_full_unstemmed | P-1667. Clinical, Laboratory, and Antimicrobial Resistance Patterns in Patients with Diabetic Foot Ulcers during the COVID-19 Pandemic in a Tertiary Care Hospital in Lima, Peru |
| title_short | P-1667. Clinical, Laboratory, and Antimicrobial Resistance Patterns in Patients with Diabetic Foot Ulcers during the COVID-19 Pandemic in a Tertiary Care Hospital in Lima, Peru |
| title_sort | p 1667 clinical laboratory and antimicrobial resistance patterns in patients with diabetic foot ulcers during the covid 19 pandemic in a tertiary care hospital in lima peru |
| topic | diabetic foot ulcer type 2 diabetes COVID-19 pandemic antimicrobial resistance methicillin-resistant Staphylococcus aureus extended-spectrum beta-lactamase co-infection Gram-negative bacteria Staphylococcus aureus Escherichia faecalis Escherichia coli surgical debridement amputation glycemic control Wagner grade Lima emergency department Diabetic Foot Ulcer Assessment and Management Antibiotic Use and Resistance Orthopedic Infections and Treatments |
| topic_facet | diabetic foot ulcer type 2 diabetes COVID-19 pandemic antimicrobial resistance methicillin-resistant Staphylococcus aureus extended-spectrum beta-lactamase co-infection Gram-negative bacteria Staphylococcus aureus Escherichia faecalis Escherichia coli surgical debridement amputation glycemic control Wagner grade Lima emergency department Diabetic Foot Ulcer Assessment and Management Antibiotic Use and Resistance Orthopedic Infections and Treatments |
| url | https://doi.org/10.1093/ofid/ofaf695.1841 |
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