Cognitive Profiles in Alzheimer's Disease: Insights from a Multicenter Study in Peru
BACKGROUND: Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are progressive neurodegenerative conditions affecting cognition and daily functioning. In Peru, this is the first multi-site study conducted across Lima, Arequipa, Puno, Chiclayo, and Loreto to evaluate cognitive performance u...
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2025
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| author | Jonathan Adrian Zegarra-Valdivia Milagros del Rocio Casimiro‐Arana Leandro Aron Perez‐Fernandez Harold Alessandro Arana‐Nombera Viviana Nayelli Gallegos‐Manayay María del Rosario Oliva‐Piscoya Reyna Elizabeth Alamo‐Medina Leslie Magdalena Lozada Tantarico Brenda Nadia Chino Vilca Carmen Paredes-Manrique Jose Carreño‐Galvez José Cabrejo Ernesto Gabriel Adolfo‐Espinoza Emily Gonzales‐Manayalle Diana Gutierrez-Flores Gilda Flores-Valdivia Noelia Graciela Raffo‐Moron César Ramal‐Ansayac María Celinda Cruz Ordinola Nilton Custodio Sheila Castro‐Suárez |
| author_browse | Brenda Nadia Chino Vilca Carmen Paredes-Manrique César Ramal‐Ansayac Diana Gutierrez-Flores Emily Gonzales‐Manayalle Ernesto Gabriel Adolfo‐Espinoza Gilda Flores-Valdivia Harold Alessandro Arana‐Nombera Jonathan Adrian Zegarra-Valdivia Jose Carreño‐Galvez José Cabrejo Leandro Aron Perez‐Fernandez Leslie Magdalena Lozada Tantarico María Celinda Cruz Ordinola María del Rosario Oliva‐Piscoya Milagros del Rocio Casimiro‐Arana Nilton Custodio Noelia Graciela Raffo‐Moron Reyna Elizabeth Alamo‐Medina Sheila Castro‐Suárez Viviana Nayelli Gallegos‐Manayay |
| author_facet | Jonathan Adrian Zegarra-Valdivia Milagros del Rocio Casimiro‐Arana Leandro Aron Perez‐Fernandez Harold Alessandro Arana‐Nombera Viviana Nayelli Gallegos‐Manayay María del Rosario Oliva‐Piscoya Reyna Elizabeth Alamo‐Medina Leslie Magdalena Lozada Tantarico Brenda Nadia Chino Vilca Carmen Paredes-Manrique Jose Carreño‐Galvez José Cabrejo Ernesto Gabriel Adolfo‐Espinoza Emily Gonzales‐Manayalle Diana Gutierrez-Flores Gilda Flores-Valdivia Noelia Graciela Raffo‐Moron César Ramal‐Ansayac María Celinda Cruz Ordinola Nilton Custodio Sheila Castro‐Suárez |
| author_sort | Jonathan Adrian Zegarra-Valdivia |
| collection | Producción científica |
| description | BACKGROUND: Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are progressive neurodegenerative conditions affecting cognition and daily functioning. In Peru, this is the first multi-site study conducted across Lima, Arequipa, Puno, Chiclayo, and Loreto to evaluate cognitive performance using standardized neuropsychological instruments. The objective was to characterize participants with MCI and AD through a comprehensive neuropsychological assessment. METHOD: A total of 267 patients were evaluated, including 145 controls, 41 individuals with MCI, and 81 with AD. Standardized assessments included PHQ-9, Pfeffer, RUDAS, and INECO. RUDAS and INECO scores were compared between groups using appropriate statistical tests (T-Student or Mann-Whitney U). RESULT: AD patients exhibited significant cognitive and executive impairments compared to controls. RUDAS Total Score: AD (11.26 ± 8.3) vs. Controls (26.61 ± 3.1, p < 0.001). INECO Total Score: AD (1.01 ± 3.29) vs. Controls (1.32 ± 4.93, p = 0.363, Mann-Whitney U). The most affected INECO subtests in AD patients included Instrucciones Conflictivas (p < 0.001) and Meses Atrás (p = 0.018). CONCLUSION: These findings confirm the severe cognitive and executive impairments in AD patients compared to MCI and controls. The significant differences in RUDAS and INECO scores highlight their potential role in differentiating neurocognitive conditions. Impairments in control inhibitory functions and working memory were evident in AD patients. This study provides novel insights into dementia evaluation in Peru and underscores the importance of standardized neuropsychological assessments for early identification of cognitive decline. Future research should expand sample sizes and refine assessment tools to improve early detection strategies. |
| format | Article |
| id | openalex:W7117304382 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | openalex:W7117304382Cognitive Profiles in Alzheimer's Disease: Insights from a Multicenter Study in PeruJonathan Adrian Zegarra-ValdiviaMilagros del Rocio Casimiro‐AranaLeandro Aron Perez‐FernandezHarold Alessandro Arana‐NomberaViviana Nayelli Gallegos‐ManayayMaría del Rosario Oliva‐PiscoyaReyna Elizabeth Alamo‐MedinaLeslie Magdalena Lozada TantaricoBrenda Nadia Chino VilcaCarmen Paredes-ManriqueJose Carreño‐GalvezJosé CabrejoErnesto Gabriel Adolfo‐EspinozaEmily Gonzales‐ManayalleDiana Gutierrez-FloresGilda Flores-ValdiviaNoelia Graciela Raffo‐MoronCésar Ramal‐AnsayacMaría Celinda Cruz OrdinolaNilton CustodioSheila Castro‐SuárezAlzheimer's diseasemild cognitive impairmentDementia and Cognitive Impairment ResearchHistorical and Modern Theater StudiesAlzheimer's disease research and treatmentsBACKGROUND: Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are progressive neurodegenerative conditions affecting cognition and daily functioning. In Peru, this is the first multi-site study conducted across Lima, Arequipa, Puno, Chiclayo, and Loreto to evaluate cognitive performance using standardized neuropsychological instruments. The objective was to characterize participants with MCI and AD through a comprehensive neuropsychological assessment. METHOD: A total of 267 patients were evaluated, including 145 controls, 41 individuals with MCI, and 81 with AD. Standardized assessments included PHQ-9, Pfeffer, RUDAS, and INECO. RUDAS and INECO scores were compared between groups using appropriate statistical tests (T-Student or Mann-Whitney U). RESULT: AD patients exhibited significant cognitive and executive impairments compared to controls. RUDAS Total Score: AD (11.26 ± 8.3) vs. Controls (26.61 ± 3.1, p < 0.001). INECO Total Score: AD (1.01 ± 3.29) vs. Controls (1.32 ± 4.93, p = 0.363, Mann-Whitney U). The most affected INECO subtests in AD patients included Instrucciones Conflictivas (p < 0.001) and Meses Atrás (p = 0.018). CONCLUSION: These findings confirm the severe cognitive and executive impairments in AD patients compared to MCI and controls. The significant differences in RUDAS and INECO scores highlight their potential role in differentiating neurocognitive conditions. Impairments in control inhibitory functions and working memory were evident in AD patients. This study provides novel insights into dementia evaluation in Peru and underscores the importance of standardized neuropsychological assessments for early identification of cognitive decline. Future research should expand sample sizes and refine assessment tools to improve early detection strategies.Articlehttps://doi.org/10.1002/alz70857_107776https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz70857_107776W7117304382enAlzheimer s & Dementia1552-52601552-52792025-12-01 |
| spellingShingle | Alzheimer's disease mild cognitive impairment Dementia and Cognitive Impairment Research Historical and Modern Theater Studies Alzheimer's disease research and treatments Jonathan Adrian Zegarra-Valdivia Milagros del Rocio Casimiro‐Arana Leandro Aron Perez‐Fernandez Harold Alessandro Arana‐Nombera Viviana Nayelli Gallegos‐Manayay María del Rosario Oliva‐Piscoya Reyna Elizabeth Alamo‐Medina Leslie Magdalena Lozada Tantarico Brenda Nadia Chino Vilca Carmen Paredes-Manrique Jose Carreño‐Galvez José Cabrejo Ernesto Gabriel Adolfo‐Espinoza Emily Gonzales‐Manayalle Diana Gutierrez-Flores Gilda Flores-Valdivia Noelia Graciela Raffo‐Moron César Ramal‐Ansayac María Celinda Cruz Ordinola Nilton Custodio Sheila Castro‐Suárez Cognitive Profiles in Alzheimer's Disease: Insights from a Multicenter Study in Peru |
| title | Cognitive Profiles in Alzheimer's Disease: Insights from a Multicenter Study in Peru |
| title_full | Cognitive Profiles in Alzheimer's Disease: Insights from a Multicenter Study in Peru |
| title_fullStr | Cognitive Profiles in Alzheimer's Disease: Insights from a Multicenter Study in Peru |
| title_full_unstemmed | Cognitive Profiles in Alzheimer's Disease: Insights from a Multicenter Study in Peru |
| title_short | Cognitive Profiles in Alzheimer's Disease: Insights from a Multicenter Study in Peru |
| title_sort | cognitive profiles in alzheimer s disease insights from a multicenter study in peru |
| topic | Alzheimer's disease mild cognitive impairment Dementia and Cognitive Impairment Research Historical and Modern Theater Studies Alzheimer's disease research and treatments |
| topic_facet | Alzheimer's disease mild cognitive impairment Dementia and Cognitive Impairment Research Historical and Modern Theater Studies Alzheimer's disease research and treatments |
| url | https://doi.org/10.1002/alz70857_107776 https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz70857_107776 |
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