Abstract 4370372: Cardiovascular outcomes for childhood cancer survivors in a diverse patient population
Background: Advances in pediatric oncology have led to a growing population of childhood cancer survivors (CCS), who are at increased risk for cardiovascular disease (CVD). Most existing data, however, come from predominantly non-Hispanic White cohorts, limiting our understanding of outcomes in dive...
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| Formato: | Conference abstract |
| Lenguaje: | inglés |
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2025
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| author | Antony Gonzales-Uribe Unaiza Ali Carlos A. Gongora Mario Jorge Garcia Leandro N. Slipczuk Min Pu Daphne T. Hsu Maryanne K. Chrisant Moriah Rabin Zhang Lili |
| author_browse | Antony Gonzales-Uribe Carlos A. Gongora Daphne T. Hsu Leandro N. Slipczuk Mario Jorge Garcia Maryanne K. Chrisant Min Pu Moriah Rabin Unaiza Ali Zhang Lili |
| author_facet | Antony Gonzales-Uribe Unaiza Ali Carlos A. Gongora Mario Jorge Garcia Leandro N. Slipczuk Min Pu Daphne T. Hsu Maryanne K. Chrisant Moriah Rabin Zhang Lili |
| author_sort | Antony Gonzales-Uribe |
| collection | Producción científica |
| description | Background: Advances in pediatric oncology have led to a growing population of childhood cancer survivors (CCS), who are at increased risk for cardiovascular disease (CVD). Most existing data, however, come from predominantly non-Hispanic White cohorts, limiting our understanding of outcomes in diverse populations. Hypothesis: Non-Hispanic Black and Hispanic CCS have worse cardiovascular outcomes, including lower ejection fraction (EF) and higher rates of heart failure (HF), compared to non-Hispanic White CCS. Methods: We conducted a retrospective cohort study of 337 CCS treated at a single academic institution. Demographic (age, sex, race/ethnicity), cancer-related (type, treatment with anthracyclines and/or radiation), and cardiac function (left ventricular ejection fraction [LVEF] or fractional shortening) were collected at baseline, post-treatment, and ≥1-year follow-up. Results: A diverse retrospective cohort of 337 childhood cancer survivors was analyzed (48% female, 11% non-Hispanic White, 21% non-Hispanic Black, 54% Hispanic). There were 143 patients with leukemia, 67 patients with lymphoma and 53 patients with sarcoma. The rest survivors (n=74) had either central nervous system tumor, germ cell tumor, neuroblastoma, or renal tumor. Age of diagnosis was 9.4±6.8 years. Among them, 76% of survivors received anthracycline-based chemotherapy with mean cumulative dose of 210.5±127mg/m 2 . Baseline cardiac function was normal in all the patients (LVEF≥50% or fractional shortening>25%) and it was similar between different racial and ethnic groups. Eleven patients (3.3%) developed clinical HF during a median follow-up time of 13 years (interquartile range 9-18 years), 4 of whom had leukemia, 3 had lymphoma, 2 had sarcoma, and 2 had other cancer types. Seven of the HF cases were non-Hispanic Black and three were Hispanic CCS. The incidence of HF in childhood cancer survivors were significantly higher in non-Hispanic Black (10%) compared to another race and ethnicity (0-2%, p=0.014). Conclusions: Non-Hispanic Black childhood cancer survivors had significantly higher rates of heart failure despite similar baseline cardiac function. |
| format | Conference abstract |
| id | openalex:W4415794710 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | openalex:W4415794710Abstract 4370372: Cardiovascular outcomes for childhood cancer survivors in a diverse patient populationAntony Gonzales-UribeUnaiza AliCarlos A. GongoraMario Jorge GarciaLeandro N. SlipczukMin PuDaphne T. HsuMaryanne K. ChrisantMoriah RabinZhang Lilichildhood cancer survivorscardiovascular diseaseheart failureleft ventricular ejection fractionracial and ethnic disparitiesnon-Hispanic Black patientsHispanic patientsanthracycline cardiotoxicityleukemialymphomasarcomaChemotherapy-induced cardiotoxicity and mitigationChildhood Cancer Survivors' Quality of LifeCardiac tumors and thrombiBackground: Advances in pediatric oncology have led to a growing population of childhood cancer survivors (CCS), who are at increased risk for cardiovascular disease (CVD). Most existing data, however, come from predominantly non-Hispanic White cohorts, limiting our understanding of outcomes in diverse populations. Hypothesis: Non-Hispanic Black and Hispanic CCS have worse cardiovascular outcomes, including lower ejection fraction (EF) and higher rates of heart failure (HF), compared to non-Hispanic White CCS. Methods: We conducted a retrospective cohort study of 337 CCS treated at a single academic institution. Demographic (age, sex, race/ethnicity), cancer-related (type, treatment with anthracyclines and/or radiation), and cardiac function (left ventricular ejection fraction [LVEF] or fractional shortening) were collected at baseline, post-treatment, and ≥1-year follow-up. Results: A diverse retrospective cohort of 337 childhood cancer survivors was analyzed (48% female, 11% non-Hispanic White, 21% non-Hispanic Black, 54% Hispanic). There were 143 patients with leukemia, 67 patients with lymphoma and 53 patients with sarcoma. The rest survivors (n=74) had either central nervous system tumor, germ cell tumor, neuroblastoma, or renal tumor. Age of diagnosis was 9.4±6.8 years. Among them, 76% of survivors received anthracycline-based chemotherapy with mean cumulative dose of 210.5±127mg/m 2 . Baseline cardiac function was normal in all the patients (LVEF≥50% or fractional shortening>25%) and it was similar between different racial and ethnic groups. Eleven patients (3.3%) developed clinical HF during a median follow-up time of 13 years (interquartile range 9-18 years), 4 of whom had leukemia, 3 had lymphoma, 2 had sarcoma, and 2 had other cancer types. Seven of the HF cases were non-Hispanic Black and three were Hispanic CCS. The incidence of HF in childhood cancer survivors were significantly higher in non-Hispanic Black (10%) compared to another race and ethnicity (0-2%, p=0.014). Conclusions: Non-Hispanic Black childhood cancer survivors had significantly higher rates of heart failure despite similar baseline cardiac function.Conference abstracthttps://doi.org/10.1161/circ.152.suppl_3.4370372W4415794710enCirculation0009-73221524-45392025-11-03 |
| spellingShingle | childhood cancer survivors cardiovascular disease heart failure left ventricular ejection fraction racial and ethnic disparities non-Hispanic Black patients Hispanic patients anthracycline cardiotoxicity leukemia lymphoma sarcoma Chemotherapy-induced cardiotoxicity and mitigation Childhood Cancer Survivors' Quality of Life Cardiac tumors and thrombi Antony Gonzales-Uribe Unaiza Ali Carlos A. Gongora Mario Jorge Garcia Leandro N. Slipczuk Min Pu Daphne T. Hsu Maryanne K. Chrisant Moriah Rabin Zhang Lili Abstract 4370372: Cardiovascular outcomes for childhood cancer survivors in a diverse patient population |
| title | Abstract 4370372: Cardiovascular outcomes for childhood cancer survivors in a diverse patient population |
| title_full | Abstract 4370372: Cardiovascular outcomes for childhood cancer survivors in a diverse patient population |
| title_fullStr | Abstract 4370372: Cardiovascular outcomes for childhood cancer survivors in a diverse patient population |
| title_full_unstemmed | Abstract 4370372: Cardiovascular outcomes for childhood cancer survivors in a diverse patient population |
| title_short | Abstract 4370372: Cardiovascular outcomes for childhood cancer survivors in a diverse patient population |
| title_sort | abstract 4370372 cardiovascular outcomes for childhood cancer survivors in a diverse patient population |
| topic | childhood cancer survivors cardiovascular disease heart failure left ventricular ejection fraction racial and ethnic disparities non-Hispanic Black patients Hispanic patients anthracycline cardiotoxicity leukemia lymphoma sarcoma Chemotherapy-induced cardiotoxicity and mitigation Childhood Cancer Survivors' Quality of Life Cardiac tumors and thrombi |
| topic_facet | childhood cancer survivors cardiovascular disease heart failure left ventricular ejection fraction racial and ethnic disparities non-Hispanic Black patients Hispanic patients anthracycline cardiotoxicity leukemia lymphoma sarcoma Chemotherapy-induced cardiotoxicity and mitigation Childhood Cancer Survivors' Quality of Life Cardiac tumors and thrombi |
| url | https://doi.org/10.1161/circ.152.suppl_3.4370372 |
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