Air Pollution and Pediatric Central Nervous Tumors: A Systematic Review of Evidence and Public Health Implications
Background: Exposure to environmental pollution, particularly air pollutants, and its relationship with childhood central nervous system (CNS) tumors is a growing public health concern. Understanding these associations is crucial for the implementation of protective measures for children and the dev...
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| Formato: | Artículo de revisión |
| Lenguaje: | inglés |
| Publicado: |
2025
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| _version_ | 1881700486989479936 |
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| author | Nantawan Koonalinthip Rogerio Diniz Takahashi Centro de Diagnósticos Brasil - Alliança Saúde, São Paulo, Brazil Tatiana Soares Jose Gabriel Lara-Amador Ramiro Sienra Centro de Oncologia e Doenças Autoimunes, São José dos Campos, Brazil Pilar Buendía Montenegro Maria Daniela Sarquis Universidad de Carabobo, Valencia, Venezuela Elmustafa Abdalla Enry Jacob Melgar-Garcia Universidad de Ciencias Médicas (UCIMED), San José, Costa Rica Ewerton Borges de Souza Lima Mariana Alcântara Roldi de Azeredo Yahaira Carpio Colmenares Carlos Betancourt-Mendez Christel Trifone Eva Borges Unidade Local de Saúde Santa Maria, Lisbon, Portugal Jessica Monteiro Vasconcellos Instituto D'Or de Pesquisa e Ensino, Brasilia, Brazil Julia Bertuzzo Tavares Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil Vitória De Ávila Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil Laura C. Ibanez-Pintor Mateus Cendon de Paula Natalia Rojas-Amaris Roger Albornoz Escuela de Medicina, Universidad Peruana Union, Lima, Perú Tobias Lerchner M Enrique Escobar Universidad Francisco Marroquin Jose Genao Ega Pontificia Universidad Católica Madre y Maestra Safa S. Almarzoky Abuhussain Inia Pérez Unidad de Infectología, Departamento de Medicina Interna, Clínica Alemana de Santiago, Chile Yusuf Adetomiwa Adelabu Arthur Gomez da Silva Netto Maria Carolina Fontana Antunes de Oliveira Khalid Mahmoud Fadlelmoula Ahmed Christianne Fernandes Valente Takeda Gabriel Vallejos-Penaloza Departamento de Ginecología y Obstetricia, Facultad de Medicina, Clínica Alemana T. Gomez-Gomez Mohamed H. Mahmoud Sundus Sardar Thalita Bento Talizin Guido Felizzia |
| author_browse | Arthur Gomez da Silva Netto Carlos Betancourt-Mendez Centro de Diagnósticos Brasil - Alliança Saúde, São Paulo, Brazil Centro de Oncologia e Doenças Autoimunes, São José dos Campos, Brazil Christel Trifone Christianne Fernandes Valente Takeda Departamento de Ginecología y Obstetricia, Facultad de Medicina, Clínica Alemana Elmustafa Abdalla Enry Jacob Melgar-Garcia Escuela de Medicina, Universidad Peruana Union, Lima, Perú Eva Borges Ewerton Borges de Souza Lima Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil Gabriel Vallejos-Penaloza Guido Felizzia Inia Pérez Instituto D'Or de Pesquisa e Ensino, Brasilia, Brazil Jessica Monteiro Vasconcellos Jose Gabriel Lara-Amador Jose Genao Ega Julia Bertuzzo Tavares Khalid Mahmoud Fadlelmoula Ahmed Laura C. Ibanez-Pintor M Enrique Escobar Maria Carolina Fontana Antunes de Oliveira Maria Daniela Sarquis Mariana Alcântara Roldi de Azeredo Mateus Cendon de Paula Mohamed H. Mahmoud Nantawan Koonalinthip Natalia Rojas-Amaris Pilar Buendía Montenegro Pontificia Universidad Católica Madre y Maestra Ramiro Sienra Roger Albornoz Rogerio Diniz Takahashi Safa S. Almarzoky Abuhussain Sundus Sardar T. Gomez-Gomez Tatiana Soares Thalita Bento Talizin Tobias Lerchner Unidad de Infectología, Departamento de Medicina Interna, Clínica Alemana de Santiago, Chile Unidade Local de Saúde Santa Maria, Lisbon, Portugal Universidad Francisco Marroquin Universidad de Carabobo, Valencia, Venezuela Universidad de Ciencias Médicas (UCIMED), San José, Costa Rica Vitória De Ávila Yahaira Carpio Colmenares Yusuf Adetomiwa Adelabu |
| author_facet | Nantawan Koonalinthip Rogerio Diniz Takahashi Centro de Diagnósticos Brasil - Alliança Saúde, São Paulo, Brazil Tatiana Soares Jose Gabriel Lara-Amador Ramiro Sienra Centro de Oncologia e Doenças Autoimunes, São José dos Campos, Brazil Pilar Buendía Montenegro Maria Daniela Sarquis Universidad de Carabobo, Valencia, Venezuela Elmustafa Abdalla Enry Jacob Melgar-Garcia Universidad de Ciencias Médicas (UCIMED), San José, Costa Rica Ewerton Borges de Souza Lima Mariana Alcântara Roldi de Azeredo Yahaira Carpio Colmenares Carlos Betancourt-Mendez Christel Trifone Eva Borges Unidade Local de Saúde Santa Maria, Lisbon, Portugal Jessica Monteiro Vasconcellos Instituto D'Or de Pesquisa e Ensino, Brasilia, Brazil Julia Bertuzzo Tavares Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil Vitória De Ávila Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil Laura C. Ibanez-Pintor Mateus Cendon de Paula Natalia Rojas-Amaris Roger Albornoz Escuela de Medicina, Universidad Peruana Union, Lima, Perú Tobias Lerchner M Enrique Escobar Universidad Francisco Marroquin Jose Genao Ega Pontificia Universidad Católica Madre y Maestra Safa S. Almarzoky Abuhussain Inia Pérez Unidad de Infectología, Departamento de Medicina Interna, Clínica Alemana de Santiago, Chile Yusuf Adetomiwa Adelabu Arthur Gomez da Silva Netto Maria Carolina Fontana Antunes de Oliveira Khalid Mahmoud Fadlelmoula Ahmed Christianne Fernandes Valente Takeda Gabriel Vallejos-Penaloza Departamento de Ginecología y Obstetricia, Facultad de Medicina, Clínica Alemana T. Gomez-Gomez Mohamed H. Mahmoud Sundus Sardar Thalita Bento Talizin Guido Felizzia |
| author_sort | Nantawan Koonalinthip |
| collection | Producción científica |
| description | Background: Exposure to environmental pollution, particularly air pollutants, and its relationship with childhood central nervous system (CNS) tumors is a growing public health concern. Understanding these associations is crucial for the implementation of protective measures for children and the development of strategic public policies. Objective: This systematic review examines the association between air pollution exposure and the risk of CNS tumors in the pediatric population aged 0-19 years. Methods: Following PRISMA guidelines, we used PubMed, SCOPUS, EMBASE, Google Scholar, and CENTRAL baselines up to May 2024. We included only observational studies focusing on children exposed to air pollutants, excluding tobacco-related exposures. Data on study design, population characteristics, exposure assessment, and types of CNS tumors were extracted and analyzed. Results: We included 25 studies (case-control and cohort) conducted across North America, Europe, Australia, and Asia. The studies assessed pollutants such as benzene, nitrogen dioxide (NO2), particulate matter (PM2.5), and polycyclic aromatic hydrocarbons (PAHs). Some studies reported positive associations between specific pollutants and increased CNS tumor risk, while others found no significant links. Variability in exposure assessment methods contributed to inconsistent findings. Conclusion: The evidence linking air pollution to childhood CNS tumors remains inconclusive. Further research, with standardized exposure assessments and consideration of critical exposure windows, is needed to clarify these associations and inform public health policies to reduce environmental risks to children. |
| format | Review |
| id | openalex:W4411141706 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | openalex:W4411141706Air Pollution and Pediatric Central Nervous Tumors: A Systematic Review of Evidence and Public Health ImplicationsNantawan KoonalinthipRogerio Diniz TakahashiCentro de Diagnósticos Brasil - Alliança Saúde, São Paulo, BrazilTatiana SoaresJose Gabriel Lara-AmadorRamiro SienraCentro de Oncologia e Doenças Autoimunes, São José dos Campos, BrazilPilar Buendía MontenegroMaria Daniela SarquisUniversidad de Carabobo, Valencia, VenezuelaElmustafa AbdallaEnry Jacob Melgar-GarciaUniversidad de Ciencias Médicas (UCIMED), San José, Costa RicaEwerton Borges de Souza LimaMariana Alcântara Roldi de AzeredoYahaira Carpio ColmenaresCarlos Betancourt-MendezChristel TrifoneEva BorgesUnidade Local de Saúde Santa Maria, Lisbon, PortugalJessica Monteiro VasconcellosInstituto D'Or de Pesquisa e Ensino, Brasilia, BrazilJulia Bertuzzo TavaresFaculdade São Leopoldo Mandic, Campinas, São Paulo, BrazilVitória De ÁvilaFaculdade São Leopoldo Mandic, Campinas, São Paulo, BrazilLaura C. Ibanez-PintorMateus Cendon de PaulaNatalia Rojas-AmarisRoger AlbornozEscuela de Medicina, Universidad Peruana Union, Lima, PerúTobias LerchnerM Enrique EscobarUniversidad Francisco MarroquinJose Genao EgaPontificia Universidad Católica Madre y MaestraSafa S. Almarzoky AbuhussainInia PérezUnidad de Infectología, Departamento de Medicina Interna, Clínica Alemana de Santiago, ChileYusuf Adetomiwa AdelabuArthur Gomez da Silva NettoMaria Carolina Fontana Antunes de OliveiraKhalid Mahmoud Fadlelmoula AhmedChristianne Fernandes Valente TakedaGabriel Vallejos-PenalozaDepartamento de Ginecología y Obstetricia, Facultad de Medicina, Clínica AlemanaT. Gomez-GomezMohamed H. MahmoudSundus SardarThalita Bento TalizinGuido Felizziaair pollutionpediatric central nervous system tumorschildhood cancerbenzenenitrogen dioxideparticulate matter PM2.5polycyclic aromatic hydrocarbonsenvironmental exposureexposure assessmentpublic health policyexposure windowsAir Quality and Health ImpactsGlioma Diagnosis and TreatmentIndoor Air Quality and Microbial ExposureBackground: Exposure to environmental pollution, particularly air pollutants, and its relationship with childhood central nervous system (CNS) tumors is a growing public health concern. Understanding these associations is crucial for the implementation of protective measures for children and the development of strategic public policies. Objective: This systematic review examines the association between air pollution exposure and the risk of CNS tumors in the pediatric population aged 0-19 years. Methods: Following PRISMA guidelines, we used PubMed, SCOPUS, EMBASE, Google Scholar, and CENTRAL baselines up to May 2024. We included only observational studies focusing on children exposed to air pollutants, excluding tobacco-related exposures. Data on study design, population characteristics, exposure assessment, and types of CNS tumors were extracted and analyzed. Results: We included 25 studies (case-control and cohort) conducted across North America, Europe, Australia, and Asia. The studies assessed pollutants such as benzene, nitrogen dioxide (NO2), particulate matter (PM2.5), and polycyclic aromatic hydrocarbons (PAHs). Some studies reported positive associations between specific pollutants and increased CNS tumor risk, while others found no significant links. Variability in exposure assessment methods contributed to inconsistent findings. Conclusion: The evidence linking air pollution to childhood CNS tumors remains inconclusive. Further research, with standardized exposure assessments and consideration of critical exposure windows, is needed to clarify these associations and inform public health policies to reduce environmental risks to children.Reviewhttps://doi.org/10.21801/ppcrj.2025.111.1https://journal.ppcr.org/index.php/ppcrjournal/article/download/350/428W4411141706enPrinciples and Practice of Clinical Research Journal2378-18902025-06-09 |
| spellingShingle | air pollution pediatric central nervous system tumors childhood cancer benzene nitrogen dioxide particulate matter PM2.5 polycyclic aromatic hydrocarbons environmental exposure exposure assessment public health policy exposure windows Air Quality and Health Impacts Glioma Diagnosis and Treatment Indoor Air Quality and Microbial Exposure Nantawan Koonalinthip Rogerio Diniz Takahashi Centro de Diagnósticos Brasil - Alliança Saúde, São Paulo, Brazil Tatiana Soares Jose Gabriel Lara-Amador Ramiro Sienra Centro de Oncologia e Doenças Autoimunes, São José dos Campos, Brazil Pilar Buendía Montenegro Maria Daniela Sarquis Universidad de Carabobo, Valencia, Venezuela Elmustafa Abdalla Enry Jacob Melgar-Garcia Universidad de Ciencias Médicas (UCIMED), San José, Costa Rica Ewerton Borges de Souza Lima Mariana Alcântara Roldi de Azeredo Yahaira Carpio Colmenares Carlos Betancourt-Mendez Christel Trifone Eva Borges Unidade Local de Saúde Santa Maria, Lisbon, Portugal Jessica Monteiro Vasconcellos Instituto D'Or de Pesquisa e Ensino, Brasilia, Brazil Julia Bertuzzo Tavares Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil Vitória De Ávila Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil Laura C. Ibanez-Pintor Mateus Cendon de Paula Natalia Rojas-Amaris Roger Albornoz Escuela de Medicina, Universidad Peruana Union, Lima, Perú Tobias Lerchner M Enrique Escobar Universidad Francisco Marroquin Jose Genao Ega Pontificia Universidad Católica Madre y Maestra Safa S. Almarzoky Abuhussain Inia Pérez Unidad de Infectología, Departamento de Medicina Interna, Clínica Alemana de Santiago, Chile Yusuf Adetomiwa Adelabu Arthur Gomez da Silva Netto Maria Carolina Fontana Antunes de Oliveira Khalid Mahmoud Fadlelmoula Ahmed Christianne Fernandes Valente Takeda Gabriel Vallejos-Penaloza Departamento de Ginecología y Obstetricia, Facultad de Medicina, Clínica Alemana T. Gomez-Gomez Mohamed H. Mahmoud Sundus Sardar Thalita Bento Talizin Guido Felizzia Air Pollution and Pediatric Central Nervous Tumors: A Systematic Review of Evidence and Public Health Implications |
| title | Air Pollution and Pediatric Central Nervous Tumors: A Systematic Review of Evidence and Public Health Implications |
| title_full | Air Pollution and Pediatric Central Nervous Tumors: A Systematic Review of Evidence and Public Health Implications |
| title_fullStr | Air Pollution and Pediatric Central Nervous Tumors: A Systematic Review of Evidence and Public Health Implications |
| title_full_unstemmed | Air Pollution and Pediatric Central Nervous Tumors: A Systematic Review of Evidence and Public Health Implications |
| title_short | Air Pollution and Pediatric Central Nervous Tumors: A Systematic Review of Evidence and Public Health Implications |
| title_sort | air pollution and pediatric central nervous tumors a systematic review of evidence and public health implications |
| topic | air pollution pediatric central nervous system tumors childhood cancer benzene nitrogen dioxide particulate matter PM2.5 polycyclic aromatic hydrocarbons environmental exposure exposure assessment public health policy exposure windows Air Quality and Health Impacts Glioma Diagnosis and Treatment Indoor Air Quality and Microbial Exposure |
| topic_facet | air pollution pediatric central nervous system tumors childhood cancer benzene nitrogen dioxide particulate matter PM2.5 polycyclic aromatic hydrocarbons environmental exposure exposure assessment public health policy exposure windows Air Quality and Health Impacts Glioma Diagnosis and Treatment Indoor Air Quality and Microbial Exposure |
| url | https://doi.org/10.21801/ppcrj.2025.111.1 https://journal.ppcr.org/index.php/ppcrjournal/article/download/350/428 |
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