Sensibilidad a fosfomicina en Escherichia coli productoras de betalactamasas de espectro extendido
Urinary infections are caused mainly by Escherichia coli (E. coli); indiscriminate use of antibiotics has caused an increase in infections due to extended-spectrum beta-lactamase (ESBL)-producing strains. Aiming to determine the sensitivity to fosfomycin, a study was conducted in ESBL-producing E. c...
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| Formato: | Artículo |
| Lenguaje: | español |
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2018
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| _version_ | 1881700432442556416 |
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| author | Sheyber J. Lifonzo-Mucha Paula E. Tamariz-Zamudio Roky Champi-Merino |
| author_browse | Paula E. Tamariz-Zamudio Roky Champi-Merino Sheyber J. Lifonzo-Mucha |
| author_facet | Sheyber J. Lifonzo-Mucha Paula E. Tamariz-Zamudio Roky Champi-Merino |
| author_sort | Sheyber J. Lifonzo-Mucha |
| collection | Producción científica |
| description | Urinary infections are caused mainly by Escherichia coli (E. coli); indiscriminate use of antibiotics has caused an increase in infections due to extended-spectrum beta-lactamase (ESBL)-producing strains. Aiming to determine the sensitivity to fosfomycin, a study was conducted in ESBL-producing E. coli strains isolated from urine cultures at a hospital in Peru. Two hundred and sixty-six (266) strains of E. coli were collected, which were determined by conventional methods to be ESBL- producing. Sensitivity to fosfomycin was determined through minimum inhibitory concentration with the agar dilution method and the diffusion disc method. One hundred and ninety-two (192) (72.2%) strains of ESBL-producing E. coli strains sensitive to Fosfomycin were found. It, therefore, follows that fosfomycin exhibits antimicrobial activity against ESBL-producing E. coli strains and that it could be considered a good treatment option for resistant strains. |
| format | Article |
| id | openalex:W2792551129 |
| institution | UPeU |
| language | Spanish |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
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| spelling | openalex:W2792551129Sensibilidad a fosfomicina en Escherichia coli productoras de betalactamasas de espectro extendidoSheyber J. Lifonzo-MuchaPaula E. Tamariz-ZamudioRoky Champi-MerinofosfomycinEscherichia coliextended-spectrum beta-lactamaseantimicrobial susceptibilityurinary tract infectionantibiotic resistanceminimum inhibitory concentrationhospital isolatesAntibiotic Resistance in BacteriaUrinary Tract Infections ManagementAntibiotics Pharmacokinetics and EfficacyUrinary infections are caused mainly by Escherichia coli (E. coli); indiscriminate use of antibiotics has caused an increase in infections due to extended-spectrum beta-lactamase (ESBL)-producing strains. Aiming to determine the sensitivity to fosfomycin, a study was conducted in ESBL-producing E. coli strains isolated from urine cultures at a hospital in Peru. Two hundred and sixty-six (266) strains of E. coli were collected, which were determined by conventional methods to be ESBL- producing. Sensitivity to fosfomycin was determined through minimum inhibitory concentration with the agar dilution method and the diffusion disc method. One hundred and ninety-two (192) (72.2%) strains of ESBL-producing E. coli strains sensitive to Fosfomycin were found. It, therefore, follows that fosfomycin exhibits antimicrobial activity against ESBL-producing E. coli strains and that it could be considered a good treatment option for resistant strains.Articlehttps://doi.org/10.17843/rpmesp.2018.351.3566https://rpmesp.ins.gob.pe/index.php/rpmesp/article/download/3566/2945W2792551129esRevista Peruana de Medicina Experimental y Salud Pública1726-46341726-46422018-03-23 |
| spellingShingle | fosfomycin Escherichia coli extended-spectrum beta-lactamase antimicrobial susceptibility urinary tract infection antibiotic resistance minimum inhibitory concentration hospital isolates Antibiotic Resistance in Bacteria Urinary Tract Infections Management Antibiotics Pharmacokinetics and Efficacy Sheyber J. Lifonzo-Mucha Paula E. Tamariz-Zamudio Roky Champi-Merino Sensibilidad a fosfomicina en Escherichia coli productoras de betalactamasas de espectro extendido |
| title | Sensibilidad a fosfomicina en Escherichia coli productoras de betalactamasas de espectro extendido |
| title_full | Sensibilidad a fosfomicina en Escherichia coli productoras de betalactamasas de espectro extendido |
| title_fullStr | Sensibilidad a fosfomicina en Escherichia coli productoras de betalactamasas de espectro extendido |
| title_full_unstemmed | Sensibilidad a fosfomicina en Escherichia coli productoras de betalactamasas de espectro extendido |
| title_short | Sensibilidad a fosfomicina en Escherichia coli productoras de betalactamasas de espectro extendido |
| title_sort | sensibilidad a fosfomicina en escherichia coli productoras de betalactamasas de espectro extendido |
| topic | fosfomycin Escherichia coli extended-spectrum beta-lactamase antimicrobial susceptibility urinary tract infection antibiotic resistance minimum inhibitory concentration hospital isolates Antibiotic Resistance in Bacteria Urinary Tract Infections Management Antibiotics Pharmacokinetics and Efficacy |
| topic_facet | fosfomycin Escherichia coli extended-spectrum beta-lactamase antimicrobial susceptibility urinary tract infection antibiotic resistance minimum inhibitory concentration hospital isolates Antibiotic Resistance in Bacteria Urinary Tract Infections Management Antibiotics Pharmacokinetics and Efficacy |
| url | https://doi.org/10.17843/rpmesp.2018.351.3566 https://rpmesp.ins.gob.pe/index.php/rpmesp/article/download/3566/2945 |
| work_keys_str_mv | AT sheyberjlifonzomucha sensibilidadafosfomicinaenescherichiacoliproductorasdebetalactamasasdeespectroextendido AT paulaetamarizzamudio sensibilidadafosfomicinaenescherichiacoliproductorasdebetalactamasasdeespectroextendido AT rokychampimerino sensibilidadafosfomicinaenescherichiacoliproductorasdebetalactamasasdeespectroextendido |