Insulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from Peru
Background. Cardiovascular diseases (CVD) are the most prevalent cause of death from disease and disability in the world. Reliable markers are needed to assess and reduce cardiovascular risk. The aim of this study was to determine if insulin resistance indexes, triglycerides to HDL-cholesterol ratio...
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| Formato: | Tesis de pregrado |
| Lenguaje: | inglés |
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Universidad Peruana Unión
2021
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| _version_ | 1881510486323757056 |
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| author | Rojas Humpire, Ricardo Josue |
| author2 | Huancahuire Vega, Salomon |
| author_browse | Huancahuire Vega, Salomon Rojas Humpire, Ricardo Josue |
| author_facet | Huancahuire Vega, Salomon Rojas Humpire, Ricardo Josue |
| author_sort | Rojas Humpire, Ricardo Josue |
| collection | Repositorio institucional |
| description | Background. Cardiovascular diseases (CVD) are the most prevalent cause of death from disease and disability in the world. Reliable markers are needed to assess and reduce cardiovascular risk. The aim of this study was to determine if insulin resistance indexes, triglycerides to HDL-cholesterol ratio (TG/HDL-c) and triglycerides to glucose index (TGI), are biomarkers for lifetime cardiovascular risk. Methods. This analytical cross-sectional study was performed in health workers from the Hospital de Huaycan in Peru. The QRISK model was used to measure lifetime cardiovascular risk. The association and diagnostic accuracy for insulin resistance indexes were determined using Poisson regression models and ROC curves with Youden index, respectively. Results. In total 291 adults (207 women and 84 men) were analyzed. In the multivariable analysis the 3rd tertil of TG/HDL-c (PRa:2.72, CI95% 1.13 - 6.57) and TGI (PRa:4.73, CI95% 1.56 - 14.31) increased significantly the lifetime cardiovascular risk compared to their 1st tertil. The cut-off values of TG/HDL-c was 2.64 (AUC:0.77), 3.90 (AUC:0.80) and 2.64 (AUC:0.74) for the overall population, men and women, respectively. Likewise, the cut-off values of TGI was 9.04 (AUC:0.80), 8.95 (AUC:0.79) and 9.04 (AUC:0.80) for the overall population, men and women, respectively. Conclusion. TG/HDL-c and TGI presented significant association with lifetime cardiovascular risk. However, TGI presented a stronger association than TG/HDL-c. Both TG/HDL-c and TGI are shown to be reliable markers for cardiovascular risk in adults. |
| escuela_str_mv | Escuela Profesional de Medicina Humana |
| format | info:eu-repo/semantics/bachelorThesis |
| id | oai:repositorio.upeu.edu.pe:20.500.12840/4656 |
| institution | UPeU |
| language | English |
| linea_str_mv | Enfermedades no infecciosas |
| ocde_area_str_mv | Ciencias médicas y de la salud |
| ocde_disciplina_str_mv | Medicina clínica |
| ocde_str_mv | 3.02.04 |
| programa_nombre_str_mv | Medicina Humana |
| programa_pxx_str_mv | P30 |
| programa_uri_str_mv | http://upeu.edu.pe/sys/programas/programa/medicina-humana |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Universidad Peruana Unión |
| publisherStr | Universidad Peruana Unión |
| record_format | dspace |
| sede_str_mv | Lima |
| spelling | Insulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from Peru Rojas Humpire, Ricardo Josue Huancahuire Vega, Salomon Cardiovascular diseases Insulin resistance Biomarkers Primary prevention Background. Cardiovascular diseases (CVD) are the most prevalent cause of death from disease and disability in the world. Reliable markers are needed to assess and reduce cardiovascular risk. The aim of this study was to determine if insulin resistance indexes, triglycerides to HDL-cholesterol ratio (TG/HDL-c) and triglycerides to glucose index (TGI), are biomarkers for lifetime cardiovascular risk. Methods. This analytical cross-sectional study was performed in health workers from the Hospital de Huaycan in Peru. The QRISK model was used to measure lifetime cardiovascular risk. The association and diagnostic accuracy for insulin resistance indexes were determined using Poisson regression models and ROC curves with Youden index, respectively. Results. In total 291 adults (207 women and 84 men) were analyzed. In the multivariable analysis the 3rd tertil of TG/HDL-c (PRa:2.72, CI95% 1.13 - 6.57) and TGI (PRa:4.73, CI95% 1.56 - 14.31) increased significantly the lifetime cardiovascular risk compared to their 1st tertil. The cut-off values of TG/HDL-c was 2.64 (AUC:0.77), 3.90 (AUC:0.80) and 2.64 (AUC:0.74) for the overall population, men and women, respectively. Likewise, the cut-off values of TGI was 9.04 (AUC:0.80), 8.95 (AUC:0.79) and 9.04 (AUC:0.80) for the overall population, men and women, respectively. Conclusion. TG/HDL-c and TGI presented significant association with lifetime cardiovascular risk. However, TGI presented a stronger association than TG/HDL-c. Both TG/HDL-c and TGI are shown to be reliable markers for cardiovascular risk in adults. 2021-07-15 2021-08-12T17:31:03Z 2021-08-12T17:31:03Z info:eu-repo/semantics/bachelorThesis https://hdl.handle.net/20.500.12840/4656 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/3.0/es/ application/pdf Universidad Peruana Unión PE oai:repositorio.upeu.edu.pe:20.500.12840/4656 2026-11-10T17:45:09Z |
| spellingShingle | Cardiovascular diseases Insulin resistance Biomarkers Primary prevention Rojas Humpire, Ricardo Josue Insulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from Peru |
| title | Insulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from Peru |
| title_full | Insulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from Peru |
| title_fullStr | Insulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from Peru |
| title_full_unstemmed | Insulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from Peru |
| title_short | Insulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from Peru |
| title_sort | insulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from peru |
| topic | Cardiovascular diseases Insulin resistance Biomarkers Primary prevention |
| topic_facet | Cardiovascular diseases Insulin resistance Biomarkers Primary prevention |
| url | https://hdl.handle.net/20.500.12840/4656 |
| work_keys_str_mv | AT rojashumpirericardojosue insulinresistanceindexesasbiomarkersoflifetimecardiovascularriskamongadultsfromperu |