Effectiveness of the consumption of guava leaf on glucose levels in rats with diabetes type 2
This research work aims to evaluate the evaluation of guava leaf powder on blood glucose levels in rats (Sprague-Dawley) induced by diabetes mellitus type 2 (DM2) with the drug streptozotocin (STZ). This research has a quantitative approach, experimental design, explanatory and longitudinal cut. The...
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| Publicado en: | Revista Muro de la Investigación |
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| Autores principales: | , |
| Formato: | Artículo de revista |
| Lenguaje: | español |
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Universidad Peruana Unión
2020
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| Materias: | |
| Acceso en línea: | Ver en el sistema de origen |
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| _version_ | 1881503218108727296 |
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| author | Díaz Correa, Betty Esther Chinchay Quito, Marco Antonio |
| author_browse | Chinchay Quito, Marco Antonio Díaz Correa, Betty Esther |
| author_facet | Díaz Correa, Betty Esther Chinchay Quito, Marco Antonio |
| author_sort | Díaz Correa, Betty Esther |
| collection | Revistas |
| container_title | Revista Muro de la Investigación |
| description | This research work aims to evaluate the evaluation of guava leaf powder on blood glucose levels in rats (Sprague-Dawley) induced by diabetes mellitus type 2 (DM2) with the drug streptozotocin (STZ). This research has a quantitative approach, experimental design, explanatory and longitudinal cut. The sample consisted of 40 male rats of the Sprague-Dawley strain of 5 weeks, distributed in 3 treatment groups: non-diabetic control group, experimental group 2 and experimental group 3 respectively. For the induction process of diabetes type 2, the rats received an amount of 10% fructose for two weeks, then the drug streptozotocin (STZ) was administered intraperitoneally (50mg / kg). The experimental groups were fed by an orogastric tube, with a dose of 500mg / Kg and 1000mg / Kg of guava leaf powder, for the experimental groups comprising group 2 and group 3, respectively, for a period of 3 weeks . At the end of the treatment, the experimental groups showed a significant decrease in glycemia and a decrease in body weight. This study concludes that the dose of 1000mg / Kg of the guava leaf powder shows a greater decrease in glycemia, after consumption. |
| format | Online |
| id | oai:ojs.pkp.sfu.ca:article/1302 |
| institution | UPeU |
| issn | 2523-2886 2521-2079 |
| language | Spanish |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Universidad Peruana Unión |
| publisherStr | Universidad Peruana Unión |
| record_format | ojs |
| revista_str_mv | Revista Muro de la Investigación |
| spelling | oai:ojs.pkp.sfu.ca:article/13022020-03-27T17:43:11Z Effectiveness of the consumption of guava leaf on glucose levels in rats with diabetes type 2 Efectividad del consumo de la hoja de guayaba sobre los niveles de glucosa en ratas diabéticas tipo 2 Díaz Correa, Betty Esther Chinchay Quito, Marco Antonio Diabetes mellitus tipo II, hoja de guayaba, glucosa, estreptozotocina. Diabetes mellitus Type 2, guava leaf, glucose, streptozotocin. This research work aims to evaluate the evaluation of guava leaf powder on blood glucose levels in rats (Sprague-Dawley) induced by diabetes mellitus type 2 (DM2) with the drug streptozotocin (STZ). This research has a quantitative approach, experimental design, explanatory and longitudinal cut. The sample consisted of 40 male rats of the Sprague-Dawley strain of 5 weeks, distributed in 3 treatment groups: non-diabetic control group, experimental group 2 and experimental group 3 respectively. For the induction process of diabetes type 2, the rats received an amount of 10% fructose for two weeks, then the drug streptozotocin (STZ) was administered intraperitoneally (50mg / kg). The experimental groups were fed by an orogastric tube, with a dose of 500mg / Kg and 1000mg / Kg of guava leaf powder, for the experimental groups comprising group 2 and group 3, respectively, for a period of 3 weeks . At the end of the treatment, the experimental groups showed a significant decrease in glycemia and a decrease in body weight. This study concludes that the dose of 1000mg / Kg of the guava leaf powder shows a greater decrease in glycemia, after consumption. Este trabajo de investigación tiene como objetivo evaluar la efectividad de la hoja de guayaba en polvo sobre los niveles de glucemia en ratas (Sprague - Dawley) inducidas a diabetes mellitus tipo 2 (DM2) con el fármaco estreptozotocina (STZ). Esta investigación tiene un enfoque cuantitativo, de diseño experimental, explicativo y de corte longitudinal. La muestra estuvo conformada por 40 ratas macho de la cepa Sprague –Dawley de 5 semanas, distribuidos en 3 grupos de tratamiento: grupo control no diabético, grupo experimental 2 y grupo experimental 3 respectivamente. Para el proceso de inducción de diabetes tipo 2, las ratas recibieron una cantidad de fructuosa al 10% por dos semanas, seguidamente se les administró el fármaco estreptozotocina (STZ) por vía intraperitoneal (50mg/kg). Los grupos experimentales fueron alimentados por una sonda orogástrica, con una dosis de 500mg/Kg y 1000mg/Kg de hoja de guayaba en polvo, para los grupos experimentales que comprende el grupo 2 y el grupo 3, respectivamente, por un periodo de 3 semanas. Al finalizar el tratamiento, los grupos experimentales mostraron una disminución significativa de glicemia y un descenso de peso corporal. Este estudio concluye que la dosis de 1000mg/Kg de la hoja de guayaba en polvo, presenta mayor disminución de glicemia, luego de su consumo. Universidad Peruana Unión 2020-03-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artículo revisado por pares application/pdf https://revistas.upeu.edu.pe/r-Muro-investigaion/article/view/1302 10.17162/rmi.v5i1.1302 Revista Muro de la Investigación; Vol. 5 Núm. 1 (2020): Revista Muro de la Investigación; 58 - 68 2523-2886 2521-2079 10.17162/rmi.v5i1 spa https://revistas.upeu.edu.pe/r-Muro-investigaion/article/view/1302/1644 Derechos de autor 2020 Betty Esther Díaz Correa, Marco Antonio Chinchay Quito |
| spellingShingle | Diabetes mellitus tipo II, hoja de guayaba, glucosa, estreptozotocina. Diabetes mellitus Type 2, guava leaf, glucose, streptozotocin. Díaz Correa, Betty Esther Chinchay Quito, Marco Antonio Effectiveness of the consumption of guava leaf on glucose levels in rats with diabetes type 2 |
| title | Effectiveness of the consumption of guava leaf on glucose levels in rats with diabetes type 2 |
| title_alt | Efectividad del consumo de la hoja de guayaba sobre los niveles de glucosa en ratas diabéticas tipo 2 |
| title_full | Effectiveness of the consumption of guava leaf on glucose levels in rats with diabetes type 2 |
| title_fullStr | Effectiveness of the consumption of guava leaf on glucose levels in rats with diabetes type 2 |
| title_full_unstemmed | Effectiveness of the consumption of guava leaf on glucose levels in rats with diabetes type 2 |
| title_short | Effectiveness of the consumption of guava leaf on glucose levels in rats with diabetes type 2 |
| title_sort | effectiveness of the consumption of guava leaf on glucose levels in rats with diabetes type 2 |
| topic | Diabetes mellitus tipo II, hoja de guayaba, glucosa, estreptozotocina. Diabetes mellitus Type 2, guava leaf, glucose, streptozotocin. |
| topic_facet | Diabetes mellitus tipo II, hoja de guayaba, glucosa, estreptozotocina. Diabetes mellitus Type 2, guava leaf, glucose, streptozotocin. |
| url | https://revistas.upeu.edu.pe/r-Muro-investigaion/article/view/1302 |
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