Ecological divergence and hybridization of Neotropical Leishmania parasites
Significance Parasites are interesting models for studying speciation processes because they have a high potential for specialization, thanks to the intimate ecological association with their hosts and vectors. Yet little is known about the circumstances under which new parasite lineages emerge. Her...
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2020
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| _version_ | 1881508926100340736 |
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| author | Frederik Van den Broeck Nicholas J. Savill Hideo Imamura Mandy Sanders Ilse Maes Sinclair Cooper David Mateus Marlene Jara Vanessa Adaui Jorge Arévalo Alejandro Llanos‐Cuentas Lineth García Elisa Cupolillo Michael A. Miles Matthew Berriman Achim Schnaufer James A. Cotton Jean‐Claude Dujardin |
| author_browse | Achim Schnaufer Alejandro Llanos‐Cuentas David Mateus Elisa Cupolillo Frederik Van den Broeck Hideo Imamura Ilse Maes James A. Cotton Jean‐Claude Dujardin Jorge Arévalo Lineth García Mandy Sanders Marlene Jara Matthew Berriman Michael A. Miles Nicholas J. Savill Sinclair Cooper Vanessa Adaui |
| author_facet | Frederik Van den Broeck Nicholas J. Savill Hideo Imamura Mandy Sanders Ilse Maes Sinclair Cooper David Mateus Marlene Jara Vanessa Adaui Jorge Arévalo Alejandro Llanos‐Cuentas Lineth García Elisa Cupolillo Michael A. Miles Matthew Berriman Achim Schnaufer James A. Cotton Jean‐Claude Dujardin |
| author_sort | Frederik Van den Broeck |
| collection | Producción científica |
| description | Significance Parasites are interesting models for studying speciation processes because they have a high potential for specialization, thanks to the intimate ecological association with their hosts and vectors. Yet little is known about the circumstances under which new parasite lineages emerge. Here we studied the genome diversity of parasites of the Leishmania braziliensis species complex that inhabit both Amazonian and Andean biotas in Peru. We identify three major parasite lineages that occupy particular ecological niches and show that these emerged during forestation changes over the past 150,000 y. We furthermore discovered that meiotic recombination between Amazonian and Andean lineages resulted in full-genome hybrids presenting mixed mitochondrial genomes, providing insights into the genetic consequences of hybridization in parasitic protozoa. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/918 |
| institution | UPeU |
| language | English |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/9182026-10-30T16:14:59ZEcological divergence and hybridization of Neotropical Leishmania parasitesFrederik Van den BroeckNicholas J. SavillHideo ImamuraMandy SandersIlse MaesSinclair CooperDavid MateusMarlene JaraVanessa AdauiJorge ArévaloAlejandro Llanos‐CuentasLineth GarcíaElisa CupolilloMichael A. MilesMatthew BerrimanAchim SchnauferJames A. CottonJean‐Claude DujardinBiologyEvolutionary biologyGenomeLeishmania braziliensisMitochondrial DNAPopulationPhylogenomicsNuclear genePhylogeneticsGeneticsCladeLeishmaniasisGeneCutaneous leishmaniasisSociologyDemographyBiologyEvolutionary biologyGenomeLeishmania braziliensisMitochondrial DNAPopulationPhylogenomicsNuclear genePhylogeneticsGeneticsCladeLeishmaniasisGeneCutaneous leishmaniasisHost-Parasite Interactions geneticsHost-Parasite Interactions geneticsHost-Parasite Interactions geneticsHost-Parasite Interactions geneticsHumansHumansHumansHumansLeishmania braziliensis geneticsLeishmania braziliensis geneticsLeishmania braziliensis geneticsLeishmania braziliensis geneticsLeishmania braziliensis pathogenicityLeishmania braziliensis pathogenicityLeishmania braziliensis pathogenicityLeishmania braziliensis pathogenicityPeru epidemiologyPeru epidemiologyPeru epidemiologyPeru epidemiologyLeishmaniasis, Cutaneous geneticsLeishmaniasis, Cutaneous geneticsLeishmaniasis, Cutaneous geneticsLeishmaniasis, Cutaneous geneticsLeishmaniasis, Cutaneous epidemiologyLeishmaniasis, Cutaneous epidemiologyLeishmaniasis, Cutaneous epidemiologyLeishmaniasis, Cutaneous epidemiologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyEcosystemEcosystemEcosystemEcosystemGenetic SpeciationGenetic SpeciationGenetic SpeciationGenetic SpeciationGenome, Mitochondrial geneticsGenome, Mitochondrial geneticsGenome, Mitochondrial geneticsGenome, Mitochondrial geneticsPhylogeographyPhylogeographyPhylogeographyPhylogeographyForestsForestsForestsForestsHealth Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis StudiesPhysical Sciences Environmental Science Ecology Parasite Biology and Host InteractionsLife Sciences Immunology and Microbiology Parasitology Parasites and Host InteractionsSignificance Parasites are interesting models for studying speciation processes because they have a high potential for specialization, thanks to the intimate ecological association with their hosts and vectors. Yet little is known about the circumstances under which new parasite lineages emerge. Here we studied the genome diversity of parasites of the Leishmania braziliensis species complex that inhabit both Amazonian and Andean biotas in Peru. We identify three major parasite lineages that occupy particular ecological niches and show that these emerged during forestation changes over the past 150,000 y. We furthermore discovered that meiotic recombination between Amazonian and Andean lineages resulted in full-genome hybrids presenting mixed mitochondrial genomes, providing insights into the genetic consequences of hybridization in parasitic protozoa.Articlehttps://pubmed.ncbi.nlm.nih.gov/32958676https://www.pnas.org/content/pnas/117/40/25159.full.pdfhttps://doi.org/10.1073/pnas.192013611710.1073/pnas.1920136117https://hdl.handle.net/20.500.15037/918W3087322838enProceedings of the National Academy of Sciences0027-84241091-64902020-09-212026-06-13T09:40:25Z2026-06-13T09:40:25Z |
| spellingShingle | Biology Evolutionary biology Genome Leishmania braziliensis Mitochondrial DNA Population Phylogenomics Nuclear gene Phylogenetics Genetics Clade Leishmaniasis Gene Cutaneous leishmaniasis Sociology Demography Biology Evolutionary biology Genome Leishmania braziliensis Mitochondrial DNA Population Phylogenomics Nuclear gene Phylogenetics Genetics Clade Leishmaniasis Gene Cutaneous leishmaniasis Host-Parasite Interactions genetics Host-Parasite Interactions genetics Host-Parasite Interactions genetics Host-Parasite Interactions genetics Humans Humans Humans Humans Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis pathogenicity Leishmania braziliensis pathogenicity Leishmania braziliensis pathogenicity Leishmania braziliensis pathogenicity Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Ecosystem Ecosystem Ecosystem Ecosystem Genetic Speciation Genetic Speciation Genetic Speciation Genetic Speciation Genome, Mitochondrial genetics Genome, Mitochondrial genetics Genome, Mitochondrial genetics Genome, Mitochondrial genetics Phylogeography Phylogeography Phylogeography Phylogeography Forests Forests Forests Forests Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies Physical Sciences Environmental Science Ecology Parasite Biology and Host Interactions Life Sciences Immunology and Microbiology Parasitology Parasites and Host Interactions Frederik Van den Broeck Nicholas J. Savill Hideo Imamura Mandy Sanders Ilse Maes Sinclair Cooper David Mateus Marlene Jara Vanessa Adaui Jorge Arévalo Alejandro Llanos‐Cuentas Lineth García Elisa Cupolillo Michael A. Miles Matthew Berriman Achim Schnaufer James A. Cotton Jean‐Claude Dujardin Ecological divergence and hybridization of Neotropical Leishmania parasites |
| title | Ecological divergence and hybridization of Neotropical Leishmania parasites |
| title_full | Ecological divergence and hybridization of Neotropical Leishmania parasites |
| title_fullStr | Ecological divergence and hybridization of Neotropical Leishmania parasites |
| title_full_unstemmed | Ecological divergence and hybridization of Neotropical Leishmania parasites |
| title_short | Ecological divergence and hybridization of Neotropical Leishmania parasites |
| title_sort | ecological divergence and hybridization of neotropical leishmania parasites |
| topic | Biology Evolutionary biology Genome Leishmania braziliensis Mitochondrial DNA Population Phylogenomics Nuclear gene Phylogenetics Genetics Clade Leishmaniasis Gene Cutaneous leishmaniasis Sociology Demography Biology Evolutionary biology Genome Leishmania braziliensis Mitochondrial DNA Population Phylogenomics Nuclear gene Phylogenetics Genetics Clade Leishmaniasis Gene Cutaneous leishmaniasis Host-Parasite Interactions genetics Host-Parasite Interactions genetics Host-Parasite Interactions genetics Host-Parasite Interactions genetics Humans Humans Humans Humans Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis pathogenicity Leishmania braziliensis pathogenicity Leishmania braziliensis pathogenicity Leishmania braziliensis pathogenicity Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Ecosystem Ecosystem Ecosystem Ecosystem Genetic Speciation Genetic Speciation Genetic Speciation Genetic Speciation Genome, Mitochondrial genetics Genome, Mitochondrial genetics Genome, Mitochondrial genetics Genome, Mitochondrial genetics Phylogeography Phylogeography Phylogeography Phylogeography Forests Forests Forests Forests Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies Physical Sciences Environmental Science Ecology Parasite Biology and Host Interactions Life Sciences Immunology and Microbiology Parasitology Parasites and Host Interactions |
| topic_facet | Biology Evolutionary biology Genome Leishmania braziliensis Mitochondrial DNA Population Phylogenomics Nuclear gene Phylogenetics Genetics Clade Leishmaniasis Gene Cutaneous leishmaniasis Sociology Demography Biology Evolutionary biology Genome Leishmania braziliensis Mitochondrial DNA Population Phylogenomics Nuclear gene Phylogenetics Genetics Clade Leishmaniasis Gene Cutaneous leishmaniasis Host-Parasite Interactions genetics Host-Parasite Interactions genetics Host-Parasite Interactions genetics Host-Parasite Interactions genetics Humans Humans Humans Humans Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis pathogenicity Leishmania braziliensis pathogenicity Leishmania braziliensis pathogenicity Leishmania braziliensis pathogenicity Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous genetics Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Ecosystem Ecosystem Ecosystem Ecosystem Genetic Speciation Genetic Speciation Genetic Speciation Genetic Speciation Genome, Mitochondrial genetics Genome, Mitochondrial genetics Genome, Mitochondrial genetics Genome, Mitochondrial genetics Phylogeography Phylogeography Phylogeography Phylogeography Forests Forests Forests Forests Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies Physical Sciences Environmental Science Ecology Parasite Biology and Host Interactions Life Sciences Immunology and Microbiology Parasitology Parasites and Host Interactions |
| url | https://pubmed.ncbi.nlm.nih.gov/32958676 https://www.pnas.org/content/pnas/117/40/25159.full.pdf https://doi.org/10.1073/pnas.1920136117 https://hdl.handle.net/20.500.15037/918 |
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