Application of CRISPR/Cas9-Based Reverse Genetics in Leishmania braziliensis: Conserved Roles for HSP100 and HSP23

The protozoan parasite Leishmania (Viannia) braziliensis (L. braziliensis) is the main cause of human tegumentary leishmaniasis in the New World, a disease affecting the skin and/or mucosal tissues. Despite its importance, the study of the unique biology of L. braziliensis through reverse genetics a...

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Guardado en:
Autores principales: Vanessa Adaui, Constanze Kröber-Boncardo, Christine Brinker, Henner Zirpel, Julie Sellau, Jorge Arévalo, Jean‐Claude Dujardin, Joachim Clos
Formato: Artículo
Lenguaje:inglés
Publicado: 2020
Materias:
CRISPR
Biology
Leishmania braziliensis
Leishmania
Gene
Genetics
Leishmaniasis
Cas9
Virology
Cutaneous leishmaniasis
Parasite hosting
World Wide Web
Computer science
Thermotolerance
Gene Editing
Heat-Shock Proteins genetics
Heat-Shock Proteins metabolism
Leishmania braziliensis genetics
Leishmania braziliensis physiology
Mutation
Protozoan Proteins genetics
Protozoan Proteins metabolism
Polymerase Chain Reaction
Genes, Protozoan
Leishmania major genetics
Leishmania major physiology
Gene Targeting
Endopeptidase Clp genetics
Endopeptidase Clp metabolism
Reverse Genetics
CRISPR-Cas Systems
Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies
Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology CRISPR and Genetic Engineering
Health Sciences Medicine Epidemiology Trypanosoma species research and implications
Acceso en línea:Ver en el sistema de origen
Ver en el sistema de origen
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Enlace permanente (DOI o Handle)
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