Parasite hybridization promotes spreading of endosymbiotic viruses
ABSTRACT Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of endosymbiotic viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here...
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| Formato: | Preprint |
| Lenguaje: | inglés |
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2023
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| author | Senne Heeren Ilse Maes Mandy Sanders Lon‐Fye Lye Jorge Arévalo Alejandro Llanos‐Cuentas Lineth García Philippe Lemey Stephen M. Beverley James A. Cotton Jean‐Claude Dujardin Frederik Van den Broeck |
| author_browse | Alejandro Llanos‐Cuentas Frederik Van den Broeck Ilse Maes James A. Cotton Jean‐Claude Dujardin Jorge Arévalo Lineth García Lon‐Fye Lye Mandy Sanders Philippe Lemey Senne Heeren Stephen M. Beverley |
| author_facet | Senne Heeren Ilse Maes Mandy Sanders Lon‐Fye Lye Jorge Arévalo Alejandro Llanos‐Cuentas Lineth García Philippe Lemey Stephen M. Beverley James A. Cotton Jean‐Claude Dujardin Frederik Van den Broeck |
| author_sort | Senne Heeren |
| collection | Producción científica |
| description | ABSTRACT Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of endosymbiotic viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis parasites and their endosymbiotic Leishmania RNA virus. We show that parasite populations circulate in isolated pockets of suitable habitat and are associated with single viral lineages that appear in low prevalence. In contrast, groups of hybrid parasites were geographically and ecologically dispersed, and commonly infected from a pool of genetically diverse viruses. Our results suggest that parasite hybridization, likely due to increased human migration and ecological perturbations, increased the frequency of endosymbiotic interactions known to play a key role in disease severity. |
| format | Preprint |
| id | oai:cris.upeu.edu.pe:20.500.15037/902 |
| institution | UPeU |
| language | English |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/9022026-10-30T16:14:58ZParasite hybridization promotes spreading of endosymbiotic virusesSenne HeerenIlse MaesMandy SandersLon‐Fye LyeJorge ArévaloAlejandro Llanos‐CuentasLineth GarcíaPhilippe LemeyStephen M. BeverleyJames A. CottonJean‐Claude DujardinFrederik Van den BroeckBiologyParasite hostingSymbiosisVirologyEvolutionary biologyGeneticsBacteriaComputer scienceWorld Wide WebBiologyParasite hostingSymbiosisVirologyEvolutionary biologyGeneticsBacteriaComputer scienceWorld Wide WebLife Sciences Agricultural and Biological Sciences Plant Science Plant Virus Research StudiesLife Sciences Biochemistry, Genetics and Molecular Biology Endocrinology Plant and Fungal Interactions ResearchPhysical Sciences Environmental Science Ecology Bacteriophages and microbial interactionsABSTRACT Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of endosymbiotic viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis parasites and their endosymbiotic Leishmania RNA virus. We show that parasite populations circulate in isolated pockets of suitable habitat and are associated with single viral lineages that appear in low prevalence. In contrast, groups of hybrid parasites were geographically and ecologically dispersed, and commonly infected from a pool of genetically diverse viruses. Our results suggest that parasite hybridization, likely due to increased human migration and ecological perturbations, increased the frequency of endosymbiotic interactions known to play a key role in disease severity.Preprinthttps://pubmed.ncbi.nlm.nih.gov/36993291https://www.biorxiv.org/content/biorxiv/early/2023/03/25/2023.03.24.534103.full.pdfhttps://doi.org/10.1101/2023.03.24.53410310.1101/2023.03.24.534103https://hdl.handle.net/20.500.15037/902W4360942569en2023-03-252026-06-13T09:40:01Z2026-06-13T09:40:01Z |
| spellingShingle | Biology Parasite hosting Symbiosis Virology Evolutionary biology Genetics Bacteria Computer science World Wide Web Biology Parasite hosting Symbiosis Virology Evolutionary biology Genetics Bacteria Computer science World Wide Web Life Sciences Agricultural and Biological Sciences Plant Science Plant Virus Research Studies Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology Plant and Fungal Interactions Research Physical Sciences Environmental Science Ecology Bacteriophages and microbial interactions Senne Heeren Ilse Maes Mandy Sanders Lon‐Fye Lye Jorge Arévalo Alejandro Llanos‐Cuentas Lineth García Philippe Lemey Stephen M. Beverley James A. Cotton Jean‐Claude Dujardin Frederik Van den Broeck Parasite hybridization promotes spreading of endosymbiotic viruses |
| title | Parasite hybridization promotes spreading of endosymbiotic viruses |
| title_full | Parasite hybridization promotes spreading of endosymbiotic viruses |
| title_fullStr | Parasite hybridization promotes spreading of endosymbiotic viruses |
| title_full_unstemmed | Parasite hybridization promotes spreading of endosymbiotic viruses |
| title_short | Parasite hybridization promotes spreading of endosymbiotic viruses |
| title_sort | parasite hybridization promotes spreading of endosymbiotic viruses |
| topic | Biology Parasite hosting Symbiosis Virology Evolutionary biology Genetics Bacteria Computer science World Wide Web Biology Parasite hosting Symbiosis Virology Evolutionary biology Genetics Bacteria Computer science World Wide Web Life Sciences Agricultural and Biological Sciences Plant Science Plant Virus Research Studies Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology Plant and Fungal Interactions Research Physical Sciences Environmental Science Ecology Bacteriophages and microbial interactions |
| topic_facet | Biology Parasite hosting Symbiosis Virology Evolutionary biology Genetics Bacteria Computer science World Wide Web Biology Parasite hosting Symbiosis Virology Evolutionary biology Genetics Bacteria Computer science World Wide Web Life Sciences Agricultural and Biological Sciences Plant Science Plant Virus Research Studies Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology Plant and Fungal Interactions Research Physical Sciences Environmental Science Ecology Bacteriophages and microbial interactions |
| url | https://pubmed.ncbi.nlm.nih.gov/36993291 https://www.biorxiv.org/content/biorxiv/early/2023/03/25/2023.03.24.534103.full.pdf https://doi.org/10.1101/2023.03.24.534103 https://hdl.handle.net/20.500.15037/902 |
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