Diversity and dissemination of viruses in pathogenic protozoa
Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecu...
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2023
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| author | Senne Heeren Ilse Maes Mandy Sanders Lon‐Fye Lye Vanessa Adaui Jorge Arévalo Alejandro Llanos‐Cuentas Lineth García Philippe Lemey Stephen M. Beverley James A. Cotton Jean‐Claude Dujardin Frederik Van den Broeck |
| author_browse | Alejandro Llanos‐Cuentas Frederik Van den Broeck Ilse Maes James A. Cotton Jean‐Claude Dujardin Jorge Arévalo Lineth García Lon‐Fye Lye Mandy Sanders Philippe Lemey Senne Heeren Stephen M. Beverley Vanessa Adaui |
| author_facet | Senne Heeren Ilse Maes Mandy Sanders Lon‐Fye Lye Vanessa Adaui Jorge Arévalo Alejandro Llanos‐Cuentas Lineth García Philippe Lemey Stephen M. Beverley James A. Cotton Jean‐Claude Dujardin Frederik Van den Broeck |
| author_sort | Senne Heeren |
| collection | Producción científica |
| description | Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis and their dsRNA Leishmania virus 1. We show that parasite populations circulate in tropical rainforests and are associated with single viral lineages that appear in low prevalence. In contrast, groups of hybrid parasites are geographically and ecologically more dispersed and associated with an increased prevalence, diversity and spread of viruses. Our results suggest that parasite gene flow and hybridization increased the frequency of parasite-virus symbioses, a process that may change the epidemiology of leishmaniasis in the region. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/899 |
| institution | UPeU |
| language | English |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/8992026-10-30T16:14:57ZDiversity and dissemination of viruses in pathogenic protozoaSenne HeerenIlse MaesMandy SandersLon‐Fye LyeVanessa AdauiJorge ArévaloAlejandro Llanos‐CuentasLineth GarcíaPhilippe LemeyStephen M. BeverleyJames A. CottonJean‐Claude DujardinFrederik Van den BroeckProtozoaDiversity (politics)BiologyVirologyEvolutionary biologyComputational biologyMicrobiologyPolitical scienceLawProtozoaDiversity (politics)BiologyVirologyEvolutionary biologyComputational biologyMicrobiologyPolitical scienceHumansHumansHumansHumansHumansHumansLeishmania geneticsLeishmania geneticsLeishmania geneticsLeishmania geneticsLeishmania geneticsLeishmania geneticsLeishmania braziliensis geneticsLeishmania braziliensis geneticsLeishmania braziliensis geneticsLeishmania braziliensis geneticsLeishmania braziliensis geneticsLeishmania braziliensis geneticsPeru epidemiologyPeru epidemiologyPeru epidemiologyPeru epidemiologyPeru epidemiologyPeru epidemiologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyEcosystemEcosystemEcosystemEcosystemEcosystemEcosystemLife Sciences Agricultural and Biological Sciences Plant Science Plant Virus Research StudiesHealth Sciences Medicine Infectious Diseases Viral Infections and VectorsLife Sciences Agricultural and Biological Sciences Insect Science Insect symbiosis and bacterial influencesViruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis and their dsRNA Leishmania virus 1. We show that parasite populations circulate in tropical rainforests and are associated with single viral lineages that appear in low prevalence. In contrast, groups of hybrid parasites are geographically and ecologically more dispersed and associated with an increased prevalence, diversity and spread of viruses. Our results suggest that parasite gene flow and hybridization increased the frequency of parasite-virus symbioses, a process that may change the epidemiology of leishmaniasis in the region.Articlehttps://pubmed.ncbi.nlm.nih.gov/38102141https://www.nature.com/articles/s41467-023-44085-2.pdfhttps://doi.org/10.1038/s41467-023-44085-210.1038/s41467-023-44085-2https://hdl.handle.net/20.500.15037/899W4389790897enNature Communications2041-17232023-12-152026-06-13T09:39:55Z2026-06-13T09:39:55Z |
| spellingShingle | Protozoa Diversity (politics) Biology Virology Evolutionary biology Computational biology Microbiology Political science Law Protozoa Diversity (politics) Biology Virology Evolutionary biology Computational biology Microbiology Political science Humans Humans Humans Humans Humans Humans Leishmania genetics Leishmania genetics Leishmania genetics Leishmania genetics Leishmania genetics Leishmania genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Ecosystem Ecosystem Ecosystem Ecosystem Ecosystem Ecosystem Life Sciences Agricultural and Biological Sciences Plant Science Plant Virus Research Studies Health Sciences Medicine Infectious Diseases Viral Infections and Vectors Life Sciences Agricultural and Biological Sciences Insect Science Insect symbiosis and bacterial influences Senne Heeren Ilse Maes Mandy Sanders Lon‐Fye Lye Vanessa Adaui Jorge Arévalo Alejandro Llanos‐Cuentas Lineth García Philippe Lemey Stephen M. Beverley James A. Cotton Jean‐Claude Dujardin Frederik Van den Broeck Diversity and dissemination of viruses in pathogenic protozoa |
| title | Diversity and dissemination of viruses in pathogenic protozoa |
| title_full | Diversity and dissemination of viruses in pathogenic protozoa |
| title_fullStr | Diversity and dissemination of viruses in pathogenic protozoa |
| title_full_unstemmed | Diversity and dissemination of viruses in pathogenic protozoa |
| title_short | Diversity and dissemination of viruses in pathogenic protozoa |
| title_sort | diversity and dissemination of viruses in pathogenic protozoa |
| topic | Protozoa Diversity (politics) Biology Virology Evolutionary biology Computational biology Microbiology Political science Law Protozoa Diversity (politics) Biology Virology Evolutionary biology Computational biology Microbiology Political science Humans Humans Humans Humans Humans Humans Leishmania genetics Leishmania genetics Leishmania genetics Leishmania genetics Leishmania genetics Leishmania genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Ecosystem Ecosystem Ecosystem Ecosystem Ecosystem Ecosystem Life Sciences Agricultural and Biological Sciences Plant Science Plant Virus Research Studies Health Sciences Medicine Infectious Diseases Viral Infections and Vectors Life Sciences Agricultural and Biological Sciences Insect Science Insect symbiosis and bacterial influences |
| topic_facet | Protozoa Diversity (politics) Biology Virology Evolutionary biology Computational biology Microbiology Political science Law Protozoa Diversity (politics) Biology Virology Evolutionary biology Computational biology Microbiology Political science Humans Humans Humans Humans Humans Humans Leishmania genetics Leishmania genetics Leishmania genetics Leishmania genetics Leishmania genetics Leishmania genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Peru epidemiology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Ecosystem Ecosystem Ecosystem Ecosystem Ecosystem Ecosystem Life Sciences Agricultural and Biological Sciences Plant Science Plant Virus Research Studies Health Sciences Medicine Infectious Diseases Viral Infections and Vectors Life Sciences Agricultural and Biological Sciences Insect Science Insect symbiosis and bacterial influences |
| url | https://pubmed.ncbi.nlm.nih.gov/38102141 https://www.nature.com/articles/s41467-023-44085-2.pdf https://doi.org/10.1038/s41467-023-44085-2 https://hdl.handle.net/20.500.15037/899 |
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