Evolutionary genomics of Leishmania braziliensis across the neotropical realm
The Neotropical realm, one of the most biodiverse regions on Earth, houses a broad range of zoonoses that pose serious public health threats. Protozoan parasites of the Leishmania (Viannia) braziliensis clade cause zoonotic leishmaniasis in Latin America with clinical symptoms ranging from simple cu...
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2024
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| author | Senne Heeren Mandy Sanders Jeffrey Jon Shaw Sinval Pinto Brandão-Filho Mariana Côrtes Boité Lilian Motta Cantanhêde Khaled Chourabi Ilse Maes Alejandro Llanos‐Cuentas Jorge Arévalo Jorge D. Marco Philippe Lemey James A. Cotton Jean‐Claude Dujardin Elisa Cupolillo Frederik Van den Broeck |
| author_browse | Alejandro Llanos‐Cuentas Elisa Cupolillo Frederik Van den Broeck Ilse Maes James A. Cotton Jean‐Claude Dujardin Jeffrey Jon Shaw Jorge Arévalo Jorge D. Marco Khaled Chourabi Lilian Motta Cantanhêde Mandy Sanders Mariana Côrtes Boité Philippe Lemey Senne Heeren Sinval Pinto Brandão-Filho |
| author_facet | Senne Heeren Mandy Sanders Jeffrey Jon Shaw Sinval Pinto Brandão-Filho Mariana Côrtes Boité Lilian Motta Cantanhêde Khaled Chourabi Ilse Maes Alejandro Llanos‐Cuentas Jorge Arévalo Jorge D. Marco Philippe Lemey James A. Cotton Jean‐Claude Dujardin Elisa Cupolillo Frederik Van den Broeck |
| author_sort | Senne Heeren |
| collection | Producción científica |
| description | The Neotropical realm, one of the most biodiverse regions on Earth, houses a broad range of zoonoses that pose serious public health threats. Protozoan parasites of the Leishmania (Viannia) braziliensis clade cause zoonotic leishmaniasis in Latin America with clinical symptoms ranging from simple cutaneous to destructive, disfiguring mucosal lesions. We present the first comprehensive genome-wide continental study including 257 cultivated isolates representing most of the geographical distribution of this major human pathogen. The L. braziliensis clade is genetically highly heterogeneous, consisting of divergent parasite groups that are associated with different environments and vary greatly in diversity. Apart from several small ecologically isolated groups with little diversity, our sampling identifies two major parasite groups, one associated with the Amazon and the other with the Atlantic Forest biomes. These groups show different recombination histories, as suggested by high levels of heterozygosity and effective population sizes in the Amazonian group in contrast to high levels of linkage and clonality in the Atlantic group. We argue that these differences are linked to strong eco-epidemiological differences between the two regions. In contrast to geographically focused studies, our study provides a broad understanding of the molecular epidemiology of zoonotic parasites circulating in tropical America. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/895 |
| institution | UPeU |
| language | English |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/8952026-10-30T16:14:57ZEvolutionary genomics of Leishmania braziliensis across the neotropical realmSenne HeerenMandy SandersJeffrey Jon ShawSinval Pinto Brandão-FilhoMariana Côrtes BoitéLilian Motta CantanhêdeKhaled ChourabiIlse MaesAlejandro Llanos‐CuentasJorge ArévaloJorge D. MarcoPhilippe LemeyJames A. CottonJean‐Claude DujardinElisa CupolilloFrederik Van den BroeckBiologyCladeAmazon rainforestLeishmania braziliensisLeishmaniaLeishmaniasisEcologyGenetic diversityRange (aeronautics)PopulationEvolutionary biologyBiodiversityZoologyCutaneous leishmaniasisPhylogeneticsGeneticsParasite hostingGeneEnvironmental healthComputer scienceComposite materialMaterials scienceMedicineWorld Wide WebBiologyCladeAmazon rainforestLeishmania braziliensisLeishmaniaLeishmaniasisEcologyGenetic diversityRange (aeronautics)PopulationEvolutionary biologyBiodiversityZoologyCutaneous leishmaniasisPhylogeneticsGeneticsParasite hostingGeneEnvironmental healthAnimalsAnimalsAnimalsAnimalsHumansHumansHumansHumansLeishmania braziliensis classificationLeishmania braziliensis classificationLeishmania braziliensis classificationLeishmania braziliensis classificationLeishmania braziliensis geneticsLeishmania braziliensis geneticsLeishmania braziliensis geneticsLeishmania braziliensis geneticsLeishmania braziliensis isolation & purificationLeishmania braziliensis isolation & purificationLeishmania braziliensis isolation & purificationLeishmania braziliensis isolation & purificationPhylogenyPhylogenyPhylogenyPhylogenyGenetic VariationGenetic VariationGenetic VariationGenetic VariationLeishmaniasis, Cutaneous epidemiologyLeishmaniasis, Cutaneous epidemiologyLeishmaniasis, Cutaneous epidemiologyLeishmaniasis, Cutaneous epidemiologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyLeishmaniasis, Cutaneous parasitologyGenome, ProtozoanGenome, ProtozoanGenome, ProtozoanGenome, ProtozoanEvolution, MolecularEvolution, MolecularEvolution, MolecularEvolution, MolecularGenomics methodsGenomics methodsGenomics methodsGenomics methodsHealth Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis StudiesHealth Sciences Medicine Epidemiology Trypanosoma species research and implicationsLife Sciences Immunology and Microbiology Parasitology Parasites and Host InteractionsThe Neotropical realm, one of the most biodiverse regions on Earth, houses a broad range of zoonoses that pose serious public health threats. Protozoan parasites of the Leishmania (Viannia) braziliensis clade cause zoonotic leishmaniasis in Latin America with clinical symptoms ranging from simple cutaneous to destructive, disfiguring mucosal lesions. We present the first comprehensive genome-wide continental study including 257 cultivated isolates representing most of the geographical distribution of this major human pathogen. The L. braziliensis clade is genetically highly heterogeneous, consisting of divergent parasite groups that are associated with different environments and vary greatly in diversity. Apart from several small ecologically isolated groups with little diversity, our sampling identifies two major parasite groups, one associated with the Amazon and the other with the Atlantic Forest biomes. These groups show different recombination histories, as suggested by high levels of heterozygosity and effective population sizes in the Amazonian group in contrast to high levels of linkage and clonality in the Atlantic group. We argue that these differences are linked to strong eco-epidemiological differences between the two regions. In contrast to geographically focused studies, our study provides a broad understanding of the molecular epidemiology of zoonotic parasites circulating in tropical America.Articlehttps://pubmed.ncbi.nlm.nih.gov/39609617https://www.nature.com/articles/s42003-024-07278-z.pdfhttps://doi.org/10.1038/s42003-024-07278-z10.1038/s42003-024-07278-zhttps://hdl.handle.net/20.500.15037/895W4404814062enCommunications Biology2399-36422024-11-282026-06-13T09:39:49Z2026-06-13T09:39:49Z |
| spellingShingle | Biology Clade Amazon rainforest Leishmania braziliensis Leishmania Leishmaniasis Ecology Genetic diversity Range (aeronautics) Population Evolutionary biology Biodiversity Zoology Cutaneous leishmaniasis Phylogenetics Genetics Parasite hosting Gene Environmental health Computer science Composite material Materials science Medicine World Wide Web Biology Clade Amazon rainforest Leishmania braziliensis Leishmania Leishmaniasis Ecology Genetic diversity Range (aeronautics) Population Evolutionary biology Biodiversity Zoology Cutaneous leishmaniasis Phylogenetics Genetics Parasite hosting Gene Environmental health Animals Animals Animals Animals Humans Humans Humans Humans Leishmania braziliensis classification Leishmania braziliensis classification Leishmania braziliensis classification Leishmania braziliensis classification Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis isolation & purification Leishmania braziliensis isolation & purification Leishmania braziliensis isolation & purification Leishmania braziliensis isolation & purification Phylogeny Phylogeny Phylogeny Phylogeny Genetic Variation Genetic Variation Genetic Variation Genetic Variation Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Genome, Protozoan Genome, Protozoan Genome, Protozoan Genome, Protozoan Evolution, Molecular Evolution, Molecular Evolution, Molecular Evolution, Molecular Genomics methods Genomics methods Genomics methods Genomics methods Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies Health Sciences Medicine Epidemiology Trypanosoma species research and implications Life Sciences Immunology and Microbiology Parasitology Parasites and Host Interactions Senne Heeren Mandy Sanders Jeffrey Jon Shaw Sinval Pinto Brandão-Filho Mariana Côrtes Boité Lilian Motta Cantanhêde Khaled Chourabi Ilse Maes Alejandro Llanos‐Cuentas Jorge Arévalo Jorge D. Marco Philippe Lemey James A. Cotton Jean‐Claude Dujardin Elisa Cupolillo Frederik Van den Broeck Evolutionary genomics of Leishmania braziliensis across the neotropical realm |
| title | Evolutionary genomics of Leishmania braziliensis across the neotropical realm |
| title_full | Evolutionary genomics of Leishmania braziliensis across the neotropical realm |
| title_fullStr | Evolutionary genomics of Leishmania braziliensis across the neotropical realm |
| title_full_unstemmed | Evolutionary genomics of Leishmania braziliensis across the neotropical realm |
| title_short | Evolutionary genomics of Leishmania braziliensis across the neotropical realm |
| title_sort | evolutionary genomics of leishmania braziliensis across the neotropical realm |
| topic | Biology Clade Amazon rainforest Leishmania braziliensis Leishmania Leishmaniasis Ecology Genetic diversity Range (aeronautics) Population Evolutionary biology Biodiversity Zoology Cutaneous leishmaniasis Phylogenetics Genetics Parasite hosting Gene Environmental health Computer science Composite material Materials science Medicine World Wide Web Biology Clade Amazon rainforest Leishmania braziliensis Leishmania Leishmaniasis Ecology Genetic diversity Range (aeronautics) Population Evolutionary biology Biodiversity Zoology Cutaneous leishmaniasis Phylogenetics Genetics Parasite hosting Gene Environmental health Animals Animals Animals Animals Humans Humans Humans Humans Leishmania braziliensis classification Leishmania braziliensis classification Leishmania braziliensis classification Leishmania braziliensis classification Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis isolation & purification Leishmania braziliensis isolation & purification Leishmania braziliensis isolation & purification Leishmania braziliensis isolation & purification Phylogeny Phylogeny Phylogeny Phylogeny Genetic Variation Genetic Variation Genetic Variation Genetic Variation Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Genome, Protozoan Genome, Protozoan Genome, Protozoan Genome, Protozoan Evolution, Molecular Evolution, Molecular Evolution, Molecular Evolution, Molecular Genomics methods Genomics methods Genomics methods Genomics methods Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies Health Sciences Medicine Epidemiology Trypanosoma species research and implications Life Sciences Immunology and Microbiology Parasitology Parasites and Host Interactions |
| topic_facet | Biology Clade Amazon rainforest Leishmania braziliensis Leishmania Leishmaniasis Ecology Genetic diversity Range (aeronautics) Population Evolutionary biology Biodiversity Zoology Cutaneous leishmaniasis Phylogenetics Genetics Parasite hosting Gene Environmental health Computer science Composite material Materials science Medicine World Wide Web Biology Clade Amazon rainforest Leishmania braziliensis Leishmania Leishmaniasis Ecology Genetic diversity Range (aeronautics) Population Evolutionary biology Biodiversity Zoology Cutaneous leishmaniasis Phylogenetics Genetics Parasite hosting Gene Environmental health Animals Animals Animals Animals Humans Humans Humans Humans Leishmania braziliensis classification Leishmania braziliensis classification Leishmania braziliensis classification Leishmania braziliensis classification Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis genetics Leishmania braziliensis isolation & purification Leishmania braziliensis isolation & purification Leishmania braziliensis isolation & purification Leishmania braziliensis isolation & purification Phylogeny Phylogeny Phylogeny Phylogeny Genetic Variation Genetic Variation Genetic Variation Genetic Variation Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous epidemiology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Leishmaniasis, Cutaneous parasitology Genome, Protozoan Genome, Protozoan Genome, Protozoan Genome, Protozoan Evolution, Molecular Evolution, Molecular Evolution, Molecular Evolution, Molecular Genomics methods Genomics methods Genomics methods Genomics methods Health Sciences Medicine Public Health, Environmental and Occupational Health Research on Leishmaniasis Studies Health Sciences Medicine Epidemiology Trypanosoma species research and implications Life Sciences Immunology and Microbiology Parasitology Parasites and Host Interactions |
| url | https://pubmed.ncbi.nlm.nih.gov/39609617 https://www.nature.com/articles/s42003-024-07278-z.pdf https://doi.org/10.1038/s42003-024-07278-z https://hdl.handle.net/20.500.15037/895 |
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