Open-Label Placebo Effects in Reducing Depression Severity Among Adults with Major Depressive Disorder: A Systematic Review and Meta-Analysis of Early Evidence

Background: Open-label placebo (OLP) represents an intervention where patients knowingly receive inert treatments associated with clinical benefits. This approach has demonstrated efficacy across multiple medical conditions. Meanwhile, major depressive disorder (MDD) affects 280 million people world...

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Autores principales: Janet Mercedes Arévalo-Ipanaqué, Maria Letícia Gobo Silva, Ricardo Romero-Vucovich, Gianluca Conte, Matheus Gerhard Rosenfeld, Sergio José Fausto Girón, Lisa Gonzalez, Jordy Batista, Sofia Ines Volpi, Maximiliano Espinosa, Daniela Lorena Alvarado Rodriguez, Salvatore Minnella, Tadeus Lopez Ulloa, Nadine Aranis Seguic, Yazmin Heredia Allegretti, Johan Antonio De La Rosa Laureano, Cristian Camilo Bermudez, Letícia Watanabe Koyama, Maria Eduarda Nabhan de Souza, Somaya Althobaiti, Karen Gamonal, Folasade Mary Adeyemi, Luis Pedro Lorenzana, Aderibigbe Adeniyi Sheriff, Peter Benedek, Emilio Vilorio-Alvarez, Wajih Jawhar
Formato: Artículo
Publicado: 2026
Materias:
Placebo
Depression (economics)
Medicine
Randomized controlled trial
Clinical trial
Psychological intervention
Placebo response
Depressive symptoms
Meta-analysis
Sample size determination
Intervention (counseling)
Physical therapy
Major depressive disorder
Psychiatry
Clinical psychology
Systematic review
MEDLINE
Strictly standardized mean difference
Internal medicine
Research design
Severity of illness
History of depression
Young adult
Randomization
Life Sciences Neuroscience Cognitive Neuroscience Pain Management and Placebo Effect
Health Sciences Medicine Pharmacology Treatment of Major Depression
Social Sciences Decision Sciences Statistics, Probability and Uncertainty Meta-analysis and systematic reviews
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