Antibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian Hospital
A descriptive design was carried out studying the correlation between antimicrobial consumption and resistance profiles of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) in a Peruvian hospi...
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2021
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| author | Giancarlo Pérez‐Lazo Susan Abarca-Salazar Renata Lovón Rocío Sáenz-Díez Rojas José Ballena‐López Adriana Morales-Moreno Wilfredo Flores-Paredes Berenice Arenas-Ramírez Luis Ricardo Illescas |
| author_browse | Adriana Morales-Moreno Berenice Arenas-Ramírez Giancarlo Pérez‐Lazo José Ballena‐López Luis Ricardo Illescas Renata Lovón Rocío Sáenz-Díez Rojas Susan Abarca-Salazar Wilfredo Flores-Paredes |
| author_facet | Giancarlo Pérez‐Lazo Susan Abarca-Salazar Renata Lovón Rocío Sáenz-Díez Rojas José Ballena‐López Adriana Morales-Moreno Wilfredo Flores-Paredes Berenice Arenas-Ramírez Luis Ricardo Illescas |
| author_sort | Giancarlo Pérez‐Lazo |
| collection | Producción científica |
| description | A descriptive design was carried out studying the correlation between antimicrobial consumption and resistance profiles of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) in a Peruvian hospital, including the surgical, clinical areas and the intensive care unit (ICU) during the time period between 2015 and 2018. There was a significant correlation between using ceftazidime and the increase of carbapenem-resistant Pseudomonas aeruginosa isolations (R = 0.97; p < 0.05) and the resistance to piperacillin/tazobactam in Enterobacter spp. and ciprofloxacin usage (R = 0.97; p < 0.05) in the medical wards. The Pseudomonas aeruginosa resistance to piperacillin/tazobactam and amikacin in the intensive care unit (ICU) had a significant reduction from 2015 to 2018 (67% vs. 28.6%, 65% vs. 34.9%, p < 0.001). These findings give valuable information about the rates and dynamics in the relationship between antibiotic usage and antimicrobial resistance patterns in a Peruvian hospital and reinforce the need for continuous support and assessment of antimicrobial stewardship strategies, including microbiological indicators and antimicrobial consumption patterns. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/773 |
| institution | UPeU |
| language | English |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/7732026-10-30T16:14:50ZAntibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian HospitalGiancarlo Pérez‐LazoSusan Abarca-SalazarRenata LovónRocío Sáenz-Díez RojasJosé Ballena‐LópezAdriana Morales-MorenoWilfredo Flores-ParedesBerenice Arenas-RamírezLuis Ricardo IllescasAntibiotic resistancePiperacillinTazobactamPseudomonas aeruginosaEnterococcus faeciumMicrobiologyAcinetobacter baumanniiMedicineAntimicrobialCeftazidimeAcinetobacterEnterobacterCiprofloxacinEnterobacter cloacaeAmikacinIntensive care unitKlebsiella pneumoniaeImipenemAntibioticsIntensive care medicineBiologyBacteriaEscherichia coliGeneGeneticsBiochemistryAntibiotic resistancePiperacillinTazobactamPseudomonas aeruginosaEnterococcus faeciumMicrobiologyAcinetobacter baumanniiMedicineAntimicrobialCeftazidimeAcinetobacterEnterobacterCiprofloxacinEnterobacter cloacaeAmikacinIntensive care unitKlebsiella pneumoniaeImipenemAntibioticsIntensive care medicineBiologyBacteriaEscherichia coliLife Sciences Immunology and Microbiology Applied Microbiology and Biotechnology Antibiotic Use and ResistanceHealth Sciences Medicine Critical Care and Intensive Care Medicine Nosocomial Infections in ICULife Sciences Biochemistry, Genetics and Molecular Biology Molecular Medicine Antibiotic Resistance in BacteriaA descriptive design was carried out studying the correlation between antimicrobial consumption and resistance profiles of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) in a Peruvian hospital, including the surgical, clinical areas and the intensive care unit (ICU) during the time period between 2015 and 2018. There was a significant correlation between using ceftazidime and the increase of carbapenem-resistant Pseudomonas aeruginosa isolations (R = 0.97; p < 0.05) and the resistance to piperacillin/tazobactam in Enterobacter spp. and ciprofloxacin usage (R = 0.97; p < 0.05) in the medical wards. The Pseudomonas aeruginosa resistance to piperacillin/tazobactam and amikacin in the intensive care unit (ICU) had a significant reduction from 2015 to 2018 (67% vs. 28.6%, 65% vs. 34.9%, p < 0.001). These findings give valuable information about the rates and dynamics in the relationship between antibiotic usage and antimicrobial resistance patterns in a Peruvian hospital and reinforce the need for continuous support and assessment of antimicrobial stewardship strategies, including microbiological indicators and antimicrobial consumption patterns.Articlehttps://pubmed.ncbi.nlm.nih.gov/34680802https://www.mdpi.com/2079-6382/10/10/1221/pdf?version=1633681298https://doi.org/10.3390/antibiotics1010122110.3390/antibiotics10101221https://hdl.handle.net/20.500.15037/773W3206492292enAntibiotics2079-63822021-10-082026-06-13T09:34:47Z2026-06-13T09:34:47Z |
| spellingShingle | Antibiotic resistance Piperacillin Tazobactam Pseudomonas aeruginosa Enterococcus faecium Microbiology Acinetobacter baumannii Medicine Antimicrobial Ceftazidime Acinetobacter Enterobacter Ciprofloxacin Enterobacter cloacae Amikacin Intensive care unit Klebsiella pneumoniae Imipenem Antibiotics Intensive care medicine Biology Bacteria Escherichia coli Gene Genetics Biochemistry Antibiotic resistance Piperacillin Tazobactam Pseudomonas aeruginosa Enterococcus faecium Microbiology Acinetobacter baumannii Medicine Antimicrobial Ceftazidime Acinetobacter Enterobacter Ciprofloxacin Enterobacter cloacae Amikacin Intensive care unit Klebsiella pneumoniae Imipenem Antibiotics Intensive care medicine Biology Bacteria Escherichia coli Life Sciences Immunology and Microbiology Applied Microbiology and Biotechnology Antibiotic Use and Resistance Health Sciences Medicine Critical Care and Intensive Care Medicine Nosocomial Infections in ICU Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Medicine Antibiotic Resistance in Bacteria Giancarlo Pérez‐Lazo Susan Abarca-Salazar Renata Lovón Rocío Sáenz-Díez Rojas José Ballena‐López Adriana Morales-Moreno Wilfredo Flores-Paredes Berenice Arenas-Ramírez Luis Ricardo Illescas Antibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian Hospital |
| title | Antibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian Hospital |
| title_full | Antibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian Hospital |
| title_fullStr | Antibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian Hospital |
| title_full_unstemmed | Antibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian Hospital |
| title_short | Antibiotic Consumption and Its Relationship with Bacterial Resistance Profiles in ESKAPE Pathogens in a Peruvian Hospital |
| title_sort | antibiotic consumption and its relationship with bacterial resistance profiles in eskape pathogens in a peruvian hospital |
| topic | Antibiotic resistance Piperacillin Tazobactam Pseudomonas aeruginosa Enterococcus faecium Microbiology Acinetobacter baumannii Medicine Antimicrobial Ceftazidime Acinetobacter Enterobacter Ciprofloxacin Enterobacter cloacae Amikacin Intensive care unit Klebsiella pneumoniae Imipenem Antibiotics Intensive care medicine Biology Bacteria Escherichia coli Gene Genetics Biochemistry Antibiotic resistance Piperacillin Tazobactam Pseudomonas aeruginosa Enterococcus faecium Microbiology Acinetobacter baumannii Medicine Antimicrobial Ceftazidime Acinetobacter Enterobacter Ciprofloxacin Enterobacter cloacae Amikacin Intensive care unit Klebsiella pneumoniae Imipenem Antibiotics Intensive care medicine Biology Bacteria Escherichia coli Life Sciences Immunology and Microbiology Applied Microbiology and Biotechnology Antibiotic Use and Resistance Health Sciences Medicine Critical Care and Intensive Care Medicine Nosocomial Infections in ICU Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Medicine Antibiotic Resistance in Bacteria |
| topic_facet | Antibiotic resistance Piperacillin Tazobactam Pseudomonas aeruginosa Enterococcus faecium Microbiology Acinetobacter baumannii Medicine Antimicrobial Ceftazidime Acinetobacter Enterobacter Ciprofloxacin Enterobacter cloacae Amikacin Intensive care unit Klebsiella pneumoniae Imipenem Antibiotics Intensive care medicine Biology Bacteria Escherichia coli Gene Genetics Biochemistry Antibiotic resistance Piperacillin Tazobactam Pseudomonas aeruginosa Enterococcus faecium Microbiology Acinetobacter baumannii Medicine Antimicrobial Ceftazidime Acinetobacter Enterobacter Ciprofloxacin Enterobacter cloacae Amikacin Intensive care unit Klebsiella pneumoniae Imipenem Antibiotics Intensive care medicine Biology Bacteria Escherichia coli Life Sciences Immunology and Microbiology Applied Microbiology and Biotechnology Antibiotic Use and Resistance Health Sciences Medicine Critical Care and Intensive Care Medicine Nosocomial Infections in ICU Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Medicine Antibiotic Resistance in Bacteria |
| url | https://pubmed.ncbi.nlm.nih.gov/34680802 https://www.mdpi.com/2079-6382/10/10/1221/pdf?version=1633681298 https://doi.org/10.3390/antibiotics10101221 https://hdl.handle.net/20.500.15037/773 |
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