Pathogenicity of Avibacterium paragallinarum Strains from Peru and the Selection of Candidate Strains for an Inactivated Vaccine
Worldwide, Avibacterium paragallinarum is the aetiological agent of infectious coryza in poultry. Vaccines are the best means of control, helping reduce clinical signs and colonization of this bacterium. Most vaccines are based on international reference strains, or, lately, regional strains, but, g...
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2022
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| author | Melanie Caballero-García Alfredo Mendoza-Espinoza Silvia Ascanio Paula Chero Rober Rojas Yosef Daniel Huberman |
| author_browse | Alfredo Mendoza-Espinoza Melanie Caballero-García Paula Chero Rober Rojas Silvia Ascanio Yosef Daniel Huberman |
| author_facet | Melanie Caballero-García Alfredo Mendoza-Espinoza Silvia Ascanio Paula Chero Rober Rojas Yosef Daniel Huberman |
| author_sort | Melanie Caballero-García |
| collection | Producción científica |
| description | Worldwide, Avibacterium paragallinarum is the aetiological agent of infectious coryza in poultry. Vaccines are the best means of control, helping reduce clinical signs and colonization of this bacterium. Most vaccines are based on international reference strains, or, lately, regional strains, but, generally, without any information regarding their virulence. The characterization of the pathogenicity of 24 Av. paragallinarum strains of the three Page serogroups, including four variant strains of serogroup B, all isolated from infectious coryza outbreaks in Peru, was performed. After experimental inoculation into the infraorbital sinuses, information regarding their capacity to induce infectious coryza typical clinical signs, spreading, and colonization was recorded. Furthermore, after intraperitoneal inoculation, septicaemia and death were registered. Differences among strains in these parameters were observed, even within strains from the same serogroup. Finally, the four most pathogenic strains, one from each serogroup, were chosen to formulate an experimental vaccine that was tested successfully against homologous challenges in reducing clinical signs and colonization in vaccinated birds compared to unvaccinated ones. This is the first time that Av. paragallinarum strains from Peru were studied thoroughly for their virulence in a search for improving vaccine formulation. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/766 |
| institution | UPeU |
| language | English |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/7662026-10-30T16:14:50ZPathogenicity of Avibacterium paragallinarum Strains from Peru and the Selection of Candidate Strains for an Inactivated VaccineMelanie Caballero-GarcíaAlfredo Mendoza-EspinozaSilvia AscanioPaula CheroRober RojasYosef Daniel HubermanVirulenceColonizationVirologyOutbreakBiologyMicrobiologySerotypeVaccinationInactivated vaccineAttenuated vaccineInoculationPathogenicityImmunologyGeneBiochemistryVirulenceColonizationVirologyOutbreakBiologyMicrobiologySerotypeVaccinationInactivated vaccineAttenuated vaccineInoculationPathogenicityImmunologyLife Sciences Immunology and Microbiology Microbiology Microbial infections and disease researchLife Sciences Immunology and Microbiology Virology Rabies epidemiology and controlLife Sciences Immunology and Microbiology Parasitology Vector-borne infectious diseasesWorldwide, Avibacterium paragallinarum is the aetiological agent of infectious coryza in poultry. Vaccines are the best means of control, helping reduce clinical signs and colonization of this bacterium. Most vaccines are based on international reference strains, or, lately, regional strains, but, generally, without any information regarding their virulence. The characterization of the pathogenicity of 24 Av. paragallinarum strains of the three Page serogroups, including four variant strains of serogroup B, all isolated from infectious coryza outbreaks in Peru, was performed. After experimental inoculation into the infraorbital sinuses, information regarding their capacity to induce infectious coryza typical clinical signs, spreading, and colonization was recorded. Furthermore, after intraperitoneal inoculation, septicaemia and death were registered. Differences among strains in these parameters were observed, even within strains from the same serogroup. Finally, the four most pathogenic strains, one from each serogroup, were chosen to formulate an experimental vaccine that was tested successfully against homologous challenges in reducing clinical signs and colonization in vaccinated birds compared to unvaccinated ones. This is the first time that Av. paragallinarum strains from Peru were studied thoroughly for their virulence in a search for improving vaccine formulation.Articlehttps://pubmed.ncbi.nlm.nih.gov/35891207https://www.mdpi.com/2076-393X/10/7/1043/pdf?version=1657096574https://doi.org/10.3390/vaccines1007104310.3390/vaccines10071043https://hdl.handle.net/20.500.15037/766W4283735778enVaccines2076-393X2022-06-292026-06-13T09:34:33Z2026-06-13T09:34:33Z |
| spellingShingle | Virulence Colonization Virology Outbreak Biology Microbiology Serotype Vaccination Inactivated vaccine Attenuated vaccine Inoculation Pathogenicity Immunology Gene Biochemistry Virulence Colonization Virology Outbreak Biology Microbiology Serotype Vaccination Inactivated vaccine Attenuated vaccine Inoculation Pathogenicity Immunology Life Sciences Immunology and Microbiology Microbiology Microbial infections and disease research Life Sciences Immunology and Microbiology Virology Rabies epidemiology and control Life Sciences Immunology and Microbiology Parasitology Vector-borne infectious diseases Melanie Caballero-García Alfredo Mendoza-Espinoza Silvia Ascanio Paula Chero Rober Rojas Yosef Daniel Huberman Pathogenicity of Avibacterium paragallinarum Strains from Peru and the Selection of Candidate Strains for an Inactivated Vaccine |
| title | Pathogenicity of Avibacterium paragallinarum Strains from Peru and the Selection of Candidate Strains for an Inactivated Vaccine |
| title_full | Pathogenicity of Avibacterium paragallinarum Strains from Peru and the Selection of Candidate Strains for an Inactivated Vaccine |
| title_fullStr | Pathogenicity of Avibacterium paragallinarum Strains from Peru and the Selection of Candidate Strains for an Inactivated Vaccine |
| title_full_unstemmed | Pathogenicity of Avibacterium paragallinarum Strains from Peru and the Selection of Candidate Strains for an Inactivated Vaccine |
| title_short | Pathogenicity of Avibacterium paragallinarum Strains from Peru and the Selection of Candidate Strains for an Inactivated Vaccine |
| title_sort | pathogenicity of avibacterium paragallinarum strains from peru and the selection of candidate strains for an inactivated vaccine |
| topic | Virulence Colonization Virology Outbreak Biology Microbiology Serotype Vaccination Inactivated vaccine Attenuated vaccine Inoculation Pathogenicity Immunology Gene Biochemistry Virulence Colonization Virology Outbreak Biology Microbiology Serotype Vaccination Inactivated vaccine Attenuated vaccine Inoculation Pathogenicity Immunology Life Sciences Immunology and Microbiology Microbiology Microbial infections and disease research Life Sciences Immunology and Microbiology Virology Rabies epidemiology and control Life Sciences Immunology and Microbiology Parasitology Vector-borne infectious diseases |
| topic_facet | Virulence Colonization Virology Outbreak Biology Microbiology Serotype Vaccination Inactivated vaccine Attenuated vaccine Inoculation Pathogenicity Immunology Gene Biochemistry Virulence Colonization Virology Outbreak Biology Microbiology Serotype Vaccination Inactivated vaccine Attenuated vaccine Inoculation Pathogenicity Immunology Life Sciences Immunology and Microbiology Microbiology Microbial infections and disease research Life Sciences Immunology and Microbiology Virology Rabies epidemiology and control Life Sciences Immunology and Microbiology Parasitology Vector-borne infectious diseases |
| url | https://pubmed.ncbi.nlm.nih.gov/35891207 https://www.mdpi.com/2076-393X/10/7/1043/pdf?version=1657096574 https://doi.org/10.3390/vaccines10071043 https://hdl.handle.net/20.500.15037/766 |
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