The Efficacy of a Trivalent Inactivated Salmonella Vaccine Combined with the Live S. Gallinarum 9R Vaccine in Young Layers after Experimental Infections with S. Enteritidis, S. Typhimurium, and S. Infantis
Worldwide, poultry infections by Salmonella are the cause of significant economic losses, not only due to reduced production (due to fowl typhoid disease), but also considering the efforts and control measures that must be constantly applied, especially due to zoonotic serovars. Poultry is a common...
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2022
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| author | Yosef Daniel Huberman Melanie Caballero-García Rober Rojas Silvia Ascanio Leandro Hipólito Olmos Rosana Malena Jorgelina Lomónaco Paula Nievas Paula Chero Julio Lévano-Gracía Alfredo Mendoza-Espinoza |
| author_browse | Alfredo Mendoza-Espinoza Jorgelina Lomónaco Julio Lévano-Gracía Leandro Hipólito Olmos Melanie Caballero-García Paula Chero Paula Nievas Rober Rojas Rosana Malena Silvia Ascanio Yosef Daniel Huberman |
| author_facet | Yosef Daniel Huberman Melanie Caballero-García Rober Rojas Silvia Ascanio Leandro Hipólito Olmos Rosana Malena Jorgelina Lomónaco Paula Nievas Paula Chero Julio Lévano-Gracía Alfredo Mendoza-Espinoza |
| author_sort | Yosef Daniel Huberman |
| collection | Producción científica |
| description | Worldwide, poultry infections by Salmonella are the cause of significant economic losses, not only due to reduced production (due to fowl typhoid disease), but also considering the efforts and control measures that must be constantly applied, especially due to zoonotic serovars. Poultry is a common reservoir of Salmonella and its transmission into the food chain is a risk for humans. The vaccination of layers plays an important role in the overall efforts to prevent Salmonella infections. An inactivated trivalent vaccine was prepared with S. Enteritidis, S. Typhimurium, and S. Infantis strains. Infection trials were performed to evaluate the efficacy of three vaccination schedules using inactivated and live S. Gallinarum 9R vaccines. For this purpose, at week 5 of life, one subcutaneous dose of live S. Gallinarum 9R vaccine (1–5 × 107 CFU) was given to Groups 1 and 2. At weeks 8 and 11 of life, chickens were also vaccinated with one (Group 1) or two (Groups 2 and 3) intramuscular doses of the inactivated oil-adjuvant trivalent vaccine (1 × 108 CFU/dose of each antigen). Group 4 consisted of chickens that remained unvaccinated (control). At week 14 of life, the efficacy of the vaccination plans was evaluated in three separate inoculation trials with S. Enteritidis, S. Typhimurium, or S. Infantis. After vaccination with the inactivated vaccine, homologous antibody production was observed, and after challenge, a significant reduction in the faecal shedding, invasion, and colonization of S. Typhimurium and S. Infantis was achieved by all vaccination schedules, while the vaccination with at least one dose of the live S. Gallinarum 9R vaccine was necessary to obtain such a significant protection against S. Enteritidis infection. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/765 |
| institution | UPeU |
| language | English |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/7652026-10-30T16:14:50ZThe Efficacy of a Trivalent Inactivated Salmonella Vaccine Combined with the Live S. Gallinarum 9R Vaccine in Young Layers after Experimental Infections with S. Enteritidis, S. Typhimurium, and S. InfantisYosef Daniel HubermanMelanie Caballero-GarcíaRober RojasSilvia AscanioLeandro Hipólito OlmosRosana MalenaJorgelina LomónacoPaula NievasPaula CheroJulio Lévano-GracíaAlfredo Mendoza-EspinozaSalmonella enteritidisMicrobiologyVirologySalmonellaBiologyBacteriaGeneticsSalmonella enteritidisMicrobiologyVirologySalmonellaBiologyBacteriaLife Sciences Agricultural and Biological Sciences Food Science Salmonella and Campylobacter epidemiologyHealth Sciences Medicine Infectious Diseases Viral gastroenteritis research and epidemiologyHealth Sciences Medicine Hepatology Hepatitis Viruses Studies and EpidemiologyWorldwide, poultry infections by Salmonella are the cause of significant economic losses, not only due to reduced production (due to fowl typhoid disease), but also considering the efforts and control measures that must be constantly applied, especially due to zoonotic serovars. Poultry is a common reservoir of Salmonella and its transmission into the food chain is a risk for humans. The vaccination of layers plays an important role in the overall efforts to prevent Salmonella infections. An inactivated trivalent vaccine was prepared with S. Enteritidis, S. Typhimurium, and S. Infantis strains. Infection trials were performed to evaluate the efficacy of three vaccination schedules using inactivated and live S. Gallinarum 9R vaccines. For this purpose, at week 5 of life, one subcutaneous dose of live S. Gallinarum 9R vaccine (1–5 × 107 CFU) was given to Groups 1 and 2. At weeks 8 and 11 of life, chickens were also vaccinated with one (Group 1) or two (Groups 2 and 3) intramuscular doses of the inactivated oil-adjuvant trivalent vaccine (1 × 108 CFU/dose of each antigen). Group 4 consisted of chickens that remained unvaccinated (control). At week 14 of life, the efficacy of the vaccination plans was evaluated in three separate inoculation trials with S. Enteritidis, S. Typhimurium, or S. Infantis. After vaccination with the inactivated vaccine, homologous antibody production was observed, and after challenge, a significant reduction in the faecal shedding, invasion, and colonization of S. Typhimurium and S. Infantis was achieved by all vaccination schedules, while the vaccination with at least one dose of the live S. Gallinarum 9R vaccine was necessary to obtain such a significant protection against S. Enteritidis infection.Articlehttps://www.mdpi.com/2076-393X/10/7/1113/pdf?version=1657798694https://doi.org/10.3390/vaccines1007111310.3390/vaccines10071113https://hdl.handle.net/20.500.15037/765W4285094237enVaccines2076-393X2022-07-122026-06-13T09:34:31Z2026-06-13T09:34:31Z |
| spellingShingle | Salmonella enteritidis Microbiology Virology Salmonella Biology Bacteria Genetics Salmonella enteritidis Microbiology Virology Salmonella Biology Bacteria Life Sciences Agricultural and Biological Sciences Food Science Salmonella and Campylobacter epidemiology Health Sciences Medicine Infectious Diseases Viral gastroenteritis research and epidemiology Health Sciences Medicine Hepatology Hepatitis Viruses Studies and Epidemiology Yosef Daniel Huberman Melanie Caballero-García Rober Rojas Silvia Ascanio Leandro Hipólito Olmos Rosana Malena Jorgelina Lomónaco Paula Nievas Paula Chero Julio Lévano-Gracía Alfredo Mendoza-Espinoza The Efficacy of a Trivalent Inactivated Salmonella Vaccine Combined with the Live S. Gallinarum 9R Vaccine in Young Layers after Experimental Infections with S. Enteritidis, S. Typhimurium, and S. Infantis |
| title | The Efficacy of a Trivalent Inactivated Salmonella Vaccine Combined with the Live S. Gallinarum 9R Vaccine in Young Layers after Experimental Infections with S. Enteritidis, S. Typhimurium, and S. Infantis |
| title_full | The Efficacy of a Trivalent Inactivated Salmonella Vaccine Combined with the Live S. Gallinarum 9R Vaccine in Young Layers after Experimental Infections with S. Enteritidis, S. Typhimurium, and S. Infantis |
| title_fullStr | The Efficacy of a Trivalent Inactivated Salmonella Vaccine Combined with the Live S. Gallinarum 9R Vaccine in Young Layers after Experimental Infections with S. Enteritidis, S. Typhimurium, and S. Infantis |
| title_full_unstemmed | The Efficacy of a Trivalent Inactivated Salmonella Vaccine Combined with the Live S. Gallinarum 9R Vaccine in Young Layers after Experimental Infections with S. Enteritidis, S. Typhimurium, and S. Infantis |
| title_short | The Efficacy of a Trivalent Inactivated Salmonella Vaccine Combined with the Live S. Gallinarum 9R Vaccine in Young Layers after Experimental Infections with S. Enteritidis, S. Typhimurium, and S. Infantis |
| title_sort | efficacy of a trivalent inactivated salmonella vaccine combined with the live s gallinarum 9r vaccine in young layers after experimental infections with s enteritidis s typhimurium and s infantis |
| topic | Salmonella enteritidis Microbiology Virology Salmonella Biology Bacteria Genetics Salmonella enteritidis Microbiology Virology Salmonella Biology Bacteria Life Sciences Agricultural and Biological Sciences Food Science Salmonella and Campylobacter epidemiology Health Sciences Medicine Infectious Diseases Viral gastroenteritis research and epidemiology Health Sciences Medicine Hepatology Hepatitis Viruses Studies and Epidemiology |
| topic_facet | Salmonella enteritidis Microbiology Virology Salmonella Biology Bacteria Genetics Salmonella enteritidis Microbiology Virology Salmonella Biology Bacteria Life Sciences Agricultural and Biological Sciences Food Science Salmonella and Campylobacter epidemiology Health Sciences Medicine Infectious Diseases Viral gastroenteritis research and epidemiology Health Sciences Medicine Hepatology Hepatitis Viruses Studies and Epidemiology |
| url | https://www.mdpi.com/2076-393X/10/7/1113/pdf?version=1657798694 https://doi.org/10.3390/vaccines10071113 https://hdl.handle.net/20.500.15037/765 |
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