Long Term Corneal Flattening After Corneal Crosslinking in Patients with Progressive Keratoconus
Purpose: We evaluate the long-term visual, refractive, and keratometric outcomes after corneal crosslinking (CXL) in patients with progressive keratoconus (KC) and the incidence of an extreme corneal flattening effect. Settings: Oftalmosalud Institute of Eyes, Lima, Perú. Design: Retrospective cohor...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2023
|
| Materias: | |
| Acceso en línea: | Ver en el sistema de origen Ver en el sistema de origen Enlace permanente (DOI o Handle) Enlace permanente (DOI o Handle) |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1881508938827956224 |
|---|---|
| author | María A. Henríquez Lisett Perez Gustavo Hernandez-Sahagun Rolando Rojas R. Doyle Stulting Luis Izquierdo |
| author_browse | Gustavo Hernandez-Sahagun Lisett Perez Luis Izquierdo María A. Henríquez R. Doyle Stulting Rolando Rojas |
| author_facet | María A. Henríquez Lisett Perez Gustavo Hernandez-Sahagun Rolando Rojas R. Doyle Stulting Luis Izquierdo |
| author_sort | María A. Henríquez |
| collection | Producción científica |
| description | Purpose: We evaluate the long-term visual, refractive, and keratometric outcomes after corneal crosslinking (CXL) in patients with progressive keratoconus (KC) and the incidence of an extreme corneal flattening effect. Settings: Oftalmosalud Institute of Eyes, Lima, Perú. Design: Retrospective cohort study. Methods: Forty-five eyes that underwent CXL with epithelial removal between June 2006 and September 2011. Data analysis was performed at preoperative evaluation, 1 year postoperatively, and at least 10 years or more postoperatively. Outcome measures included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and Scheimpflug (Pentacam) analysis. Progression was defined by an increase in steep keratometry (Ks) of 1.5D or greater between 2 examinations. Extreme flattening effect was defined as a decrease in K values equal to or greater than 5 diopters (D). Results: Mean follow-up time was 11 ± 1.07 years (range 10-13 years). There was a significant improvement in Ks, UCVA, CDVA, and spherical equivalent at the last visit. The overall rate of progression was 2.22% (1/45). Extreme flattening was observed in 15.5% (7/45) of the eyes, and this was associated with a loss of CDVA in 4.44% (2/45) of the eyes. One eye with corneal flattening of 11.5 D lost 7 lines of CDVA and required corneal transplantation. Conclusion: CXL is a safe and effective procedure to stop the progression of KC with a good overall long-term success rate. Extreme corneal flattening may be more common than commonly recognized, and severe corneal flattening associated with a decrease in CDVA may occur. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/763 |
| institution | UPeU |
| language | English |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/7632026-10-30T16:14:50ZLong Term Corneal Flattening After Corneal Crosslinking in Patients with Progressive KeratoconusMaría A. HenríquezLisett PerezGustavo Hernandez-SahagunRolando RojasR. Doyle StultingLuis IzquierdoKeratoconusMedicineOphthalmologyCorneal topographyTerm (time)FlatteningOptometryCorneaQuantum mechanicsMaterials sciencePhysicsComposite materialKeratoconusMedicineOphthalmologyCorneal topographyTerm (time)FlatteningOptometryCorneaHealth Sciences Medicine Radiology, Nuclear Medicine and Imaging Corneal surgery and disordersHealth Sciences Medicine Radiology, Nuclear Medicine and Imaging Corneal Surgery and TreatmentsHealth Sciences Medicine Public Health, Environmental and Occupational Health Ocular Surface and Contact LensPurpose: We evaluate the long-term visual, refractive, and keratometric outcomes after corneal crosslinking (CXL) in patients with progressive keratoconus (KC) and the incidence of an extreme corneal flattening effect. Settings: Oftalmosalud Institute of Eyes, Lima, Perú. Design: Retrospective cohort study. Methods: Forty-five eyes that underwent CXL with epithelial removal between June 2006 and September 2011. Data analysis was performed at preoperative evaluation, 1 year postoperatively, and at least 10 years or more postoperatively. Outcome measures included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and Scheimpflug (Pentacam) analysis. Progression was defined by an increase in steep keratometry (Ks) of 1.5D or greater between 2 examinations. Extreme flattening effect was defined as a decrease in K values equal to or greater than 5 diopters (D). Results: Mean follow-up time was 11 ± 1.07 years (range 10-13 years). There was a significant improvement in Ks, UCVA, CDVA, and spherical equivalent at the last visit. The overall rate of progression was 2.22% (1/45). Extreme flattening was observed in 15.5% (7/45) of the eyes, and this was associated with a loss of CDVA in 4.44% (2/45) of the eyes. One eye with corneal flattening of 11.5 D lost 7 lines of CDVA and required corneal transplantation. Conclusion: CXL is a safe and effective procedure to stop the progression of KC with a good overall long-term success rate. Extreme corneal flattening may be more common than commonly recognized, and severe corneal flattening associated with a decrease in CDVA may occur.Articlehttps://pubmed.ncbi.nlm.nih.gov/37425031https://www.dovepress.com/getfile.php?fileID=90879https://doi.org/10.2147/opth.s40900910.2147/opth.s409009https://hdl.handle.net/20.500.15037/763W4382927810enClinical ophthalmology1177-54671177-54832023-07-012026-06-13T09:34:27Z2026-06-13T09:34:27Z |
| spellingShingle | Keratoconus Medicine Ophthalmology Corneal topography Term (time) Flattening Optometry Cornea Quantum mechanics Materials science Physics Composite material Keratoconus Medicine Ophthalmology Corneal topography Term (time) Flattening Optometry Cornea Health Sciences Medicine Radiology, Nuclear Medicine and Imaging Corneal surgery and disorders Health Sciences Medicine Radiology, Nuclear Medicine and Imaging Corneal Surgery and Treatments Health Sciences Medicine Public Health, Environmental and Occupational Health Ocular Surface and Contact Lens María A. Henríquez Lisett Perez Gustavo Hernandez-Sahagun Rolando Rojas R. Doyle Stulting Luis Izquierdo Long Term Corneal Flattening After Corneal Crosslinking in Patients with Progressive Keratoconus |
| title | Long Term Corneal Flattening After Corneal Crosslinking in Patients with Progressive Keratoconus |
| title_full | Long Term Corneal Flattening After Corneal Crosslinking in Patients with Progressive Keratoconus |
| title_fullStr | Long Term Corneal Flattening After Corneal Crosslinking in Patients with Progressive Keratoconus |
| title_full_unstemmed | Long Term Corneal Flattening After Corneal Crosslinking in Patients with Progressive Keratoconus |
| title_short | Long Term Corneal Flattening After Corneal Crosslinking in Patients with Progressive Keratoconus |
| title_sort | long term corneal flattening after corneal crosslinking in patients with progressive keratoconus |
| topic | Keratoconus Medicine Ophthalmology Corneal topography Term (time) Flattening Optometry Cornea Quantum mechanics Materials science Physics Composite material Keratoconus Medicine Ophthalmology Corneal topography Term (time) Flattening Optometry Cornea Health Sciences Medicine Radiology, Nuclear Medicine and Imaging Corneal surgery and disorders Health Sciences Medicine Radiology, Nuclear Medicine and Imaging Corneal Surgery and Treatments Health Sciences Medicine Public Health, Environmental and Occupational Health Ocular Surface and Contact Lens |
| topic_facet | Keratoconus Medicine Ophthalmology Corneal topography Term (time) Flattening Optometry Cornea Quantum mechanics Materials science Physics Composite material Keratoconus Medicine Ophthalmology Corneal topography Term (time) Flattening Optometry Cornea Health Sciences Medicine Radiology, Nuclear Medicine and Imaging Corneal surgery and disorders Health Sciences Medicine Radiology, Nuclear Medicine and Imaging Corneal Surgery and Treatments Health Sciences Medicine Public Health, Environmental and Occupational Health Ocular Surface and Contact Lens |
| url | https://pubmed.ncbi.nlm.nih.gov/37425031 https://www.dovepress.com/getfile.php?fileID=90879 https://doi.org/10.2147/opth.s409009 https://hdl.handle.net/20.500.15037/763 |
| work_keys_str_mv | AT mariaahenriquez longtermcornealflatteningaftercornealcrosslinkinginpatientswithprogressivekeratoconus AT lisettperez longtermcornealflatteningaftercornealcrosslinkinginpatientswithprogressivekeratoconus AT gustavohernandezsahagun longtermcornealflatteningaftercornealcrosslinkinginpatientswithprogressivekeratoconus AT rolandorojas longtermcornealflatteningaftercornealcrosslinkinginpatientswithprogressivekeratoconus AT rdoylestulting longtermcornealflatteningaftercornealcrosslinkinginpatientswithprogressivekeratoconus AT luisizquierdo longtermcornealflatteningaftercornealcrosslinkinginpatientswithprogressivekeratoconus |