Factores asociados a falla virológica en pacientes infectados con VIH que reciben terapia anti-retroviral en un hospital público del Perú
OBJECTIVE: To describe clinical and biological characteristics of subjects with virologic failure who participated in the sexually transmitted diseases HIV/AIDS National Program from a Peruvian public hospital. MATERIALS AND METHODS: An exploratory descriptive study was performed with data from subj...
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2013
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| author | Jorge Alave Jorge Paz Elsa González Miguel Campos Martín Rodríguez James H. Willig Juan Echevarría |
| author_browse | Elsa González James H. Willig Jorge Alave Jorge Paz Juan Echevarría Martín Rodríguez Miguel Campos |
| author_facet | Jorge Alave Jorge Paz Elsa González Miguel Campos Martín Rodríguez James H. Willig Juan Echevarría |
| author_sort | Jorge Alave |
| collection | Producción científica |
| description | OBJECTIVE: To describe clinical and biological characteristics of subjects with virologic failure who participated in the sexually transmitted diseases HIV/AIDS National Program from a Peruvian public hospital. MATERIALS AND METHODS: An exploratory descriptive study was performed with data from subjects older than 18 who started high activity antiretroviral therapy (HAART) between May 2004 and December 2009 and who had a viral load control after 24 weeks of HAART. Virologic failure was defined as a viral load value above 1000 copies/mL on follow up after 24 weeks on HAART. RESULTS: Of 1478 records of patients on HAART analyzed, the median age was 35 years [IQR, 29-41] and 69.6% were male. Also, virologic failure occurred in 24% and 3.7% died. Of subjects with virologic failure, 9.5% died. On multivariate analysis, age, history of antiretroviral use before starting HAART, change of antiretroviral therapy due to toxicity, opportunistic infections during HAART, level of CD4 + lymphocytes below 100 cells/ml at start of HAART, adherence and clinical stage were independently associated with virologic failure. In the group of patient with no history of antiretroviral use before starting HAART, age, opportunistic infections during HAART were associated with virologic failure. CONCLUSION: This study identified factors associated with virologic failure. Further studies are needed to evaluate whether the use of these factors can help to identify prospectively patients at high risk of failure, and to design interventions aimed to reduce this risk. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/670 |
| institution | UPeU |
| language | Spanish |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/6702026-10-30T16:14:45ZFactores asociados a falla virológica en pacientes infectados con VIH que reciben terapia anti-retroviral en un hospital público del PerúJorge AlaveJorge PazElsa GonzálezMiguel CamposMartín RodríguezJames H. WilligJuan EchevarríaMedicineViral loadAntiretroviral therapyInternal medicineMultivariate analysisHuman immunodeficiency virus (HIV)PediatricsImmunologyMedicineViral loadAntiretroviral therapyInternal medicineMultivariate analysisHuman immunodeficiency virus (HIV)PediatricsImmunologyAdultAdultAdultFemaleFemaleFemaleHospitals, PublicHospitals, PublicHospitals, PublicHumansHumansHumansMaleMaleMalePeruPeruPeruRetrospective StudiesRetrospective StudiesRetrospective StudiesRisk FactorsRisk FactorsRisk FactorsHIV Infections drug therapyHIV Infections drug therapyHIV Infections drug therapyHIV Infections virologyHIV Infections virologyHIV Infections virologyTreatment FailureTreatment FailureTreatment FailureCD4 Lymphocyte CountCD4 Lymphocyte CountCD4 Lymphocyte CountAnti-HIV Agents therapeutic useAnti-HIV Agents therapeutic useAnti-HIV Agents therapeutic useViral LoadViral LoadViral LoadAntiretroviral Therapy, Highly ActiveAntiretroviral Therapy, Highly ActiveAntiretroviral Therapy, Highly ActiveHealth Sciences Medicine Infectious Diseases HIV/AIDS Research and InterventionsHealth Sciences Medicine Infectious Diseases HIV/AIDS drug development and treatmentHealth Sciences Medicine Emergency Medicine HIV-related health complications and treatmentsOBJECTIVE: To describe clinical and biological characteristics of subjects with virologic failure who participated in the sexually transmitted diseases HIV/AIDS National Program from a Peruvian public hospital. MATERIALS AND METHODS: An exploratory descriptive study was performed with data from subjects older than 18 who started high activity antiretroviral therapy (HAART) between May 2004 and December 2009 and who had a viral load control after 24 weeks of HAART. Virologic failure was defined as a viral load value above 1000 copies/mL on follow up after 24 weeks on HAART. RESULTS: Of 1478 records of patients on HAART analyzed, the median age was 35 years [IQR, 29-41] and 69.6% were male. Also, virologic failure occurred in 24% and 3.7% died. Of subjects with virologic failure, 9.5% died. On multivariate analysis, age, history of antiretroviral use before starting HAART, change of antiretroviral therapy due to toxicity, opportunistic infections during HAART, level of CD4 + lymphocytes below 100 cells/ml at start of HAART, adherence and clinical stage were independently associated with virologic failure. In the group of patient with no history of antiretroviral use before starting HAART, age, opportunistic infections during HAART were associated with virologic failure. CONCLUSION: This study identified factors associated with virologic failure. Further studies are needed to evaluate whether the use of these factors can help to identify prospectively patients at high risk of failure, and to design interventions aimed to reduce this risk.Articlehttps://pubmed.ncbi.nlm.nih.gov/23450408http://www.scielo.cl/pdf/rci/v30n1/art06.pdfhttps://doi.org/10.4067/s0716-1018201300010000610.4067/s0716-10182013000100006https://hdl.handle.net/20.500.15037/670W2017683099esRevista chilena de infectología0716-10180717-63412013-02-012026-06-13T09:30:14Z2026-06-13T09:30:14Z |
| spellingShingle | Medicine Viral load Antiretroviral therapy Internal medicine Multivariate analysis Human immunodeficiency virus (HIV) Pediatrics Immunology Medicine Viral load Antiretroviral therapy Internal medicine Multivariate analysis Human immunodeficiency virus (HIV) Pediatrics Immunology Adult Adult Adult Female Female Female Hospitals, Public Hospitals, Public Hospitals, Public Humans Humans Humans Male Male Male Peru Peru Peru Retrospective Studies Retrospective Studies Retrospective Studies Risk Factors Risk Factors Risk Factors HIV Infections drug therapy HIV Infections drug therapy HIV Infections drug therapy HIV Infections virology HIV Infections virology HIV Infections virology Treatment Failure Treatment Failure Treatment Failure CD4 Lymphocyte Count CD4 Lymphocyte Count CD4 Lymphocyte Count Anti-HIV Agents therapeutic use Anti-HIV Agents therapeutic use Anti-HIV Agents therapeutic use Viral Load Viral Load Viral Load Antiretroviral Therapy, Highly Active Antiretroviral Therapy, Highly Active Antiretroviral Therapy, Highly Active Health Sciences Medicine Infectious Diseases HIV/AIDS Research and Interventions Health Sciences Medicine Infectious Diseases HIV/AIDS drug development and treatment Health Sciences Medicine Emergency Medicine HIV-related health complications and treatments Jorge Alave Jorge Paz Elsa González Miguel Campos Martín Rodríguez James H. Willig Juan Echevarría Factores asociados a falla virológica en pacientes infectados con VIH que reciben terapia anti-retroviral en un hospital público del Perú |
| title | Factores asociados a falla virológica en pacientes infectados con VIH que reciben terapia anti-retroviral en un hospital público del Perú |
| title_full | Factores asociados a falla virológica en pacientes infectados con VIH que reciben terapia anti-retroviral en un hospital público del Perú |
| title_fullStr | Factores asociados a falla virológica en pacientes infectados con VIH que reciben terapia anti-retroviral en un hospital público del Perú |
| title_full_unstemmed | Factores asociados a falla virológica en pacientes infectados con VIH que reciben terapia anti-retroviral en un hospital público del Perú |
| title_short | Factores asociados a falla virológica en pacientes infectados con VIH que reciben terapia anti-retroviral en un hospital público del Perú |
| title_sort | factores asociados a falla virologica en pacientes infectados con vih que reciben terapia anti retroviral en un hospital publico del peru |
| topic | Medicine Viral load Antiretroviral therapy Internal medicine Multivariate analysis Human immunodeficiency virus (HIV) Pediatrics Immunology Medicine Viral load Antiretroviral therapy Internal medicine Multivariate analysis Human immunodeficiency virus (HIV) Pediatrics Immunology Adult Adult Adult Female Female Female Hospitals, Public Hospitals, Public Hospitals, Public Humans Humans Humans Male Male Male Peru Peru Peru Retrospective Studies Retrospective Studies Retrospective Studies Risk Factors Risk Factors Risk Factors HIV Infections drug therapy HIV Infections drug therapy HIV Infections drug therapy HIV Infections virology HIV Infections virology HIV Infections virology Treatment Failure Treatment Failure Treatment Failure CD4 Lymphocyte Count CD4 Lymphocyte Count CD4 Lymphocyte Count Anti-HIV Agents therapeutic use Anti-HIV Agents therapeutic use Anti-HIV Agents therapeutic use Viral Load Viral Load Viral Load Antiretroviral Therapy, Highly Active Antiretroviral Therapy, Highly Active Antiretroviral Therapy, Highly Active Health Sciences Medicine Infectious Diseases HIV/AIDS Research and Interventions Health Sciences Medicine Infectious Diseases HIV/AIDS drug development and treatment Health Sciences Medicine Emergency Medicine HIV-related health complications and treatments |
| topic_facet | Medicine Viral load Antiretroviral therapy Internal medicine Multivariate analysis Human immunodeficiency virus (HIV) Pediatrics Immunology Medicine Viral load Antiretroviral therapy Internal medicine Multivariate analysis Human immunodeficiency virus (HIV) Pediatrics Immunology Adult Adult Adult Female Female Female Hospitals, Public Hospitals, Public Hospitals, Public Humans Humans Humans Male Male Male Peru Peru Peru Retrospective Studies Retrospective Studies Retrospective Studies Risk Factors Risk Factors Risk Factors HIV Infections drug therapy HIV Infections drug therapy HIV Infections drug therapy HIV Infections virology HIV Infections virology HIV Infections virology Treatment Failure Treatment Failure Treatment Failure CD4 Lymphocyte Count CD4 Lymphocyte Count CD4 Lymphocyte Count Anti-HIV Agents therapeutic use Anti-HIV Agents therapeutic use Anti-HIV Agents therapeutic use Viral Load Viral Load Viral Load Antiretroviral Therapy, Highly Active Antiretroviral Therapy, Highly Active Antiretroviral Therapy, Highly Active Health Sciences Medicine Infectious Diseases HIV/AIDS Research and Interventions Health Sciences Medicine Infectious Diseases HIV/AIDS drug development and treatment Health Sciences Medicine Emergency Medicine HIV-related health complications and treatments |
| url | https://pubmed.ncbi.nlm.nih.gov/23450408 http://www.scielo.cl/pdf/rci/v30n1/art06.pdf https://doi.org/10.4067/s0716-10182013000100006 https://hdl.handle.net/20.500.15037/670 |
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