Leukocyte Telomere Length and Vitamin D: A Systematic Review of Observational Research
Introduction: Interest in biological markers of healthy aging has grown, particularly vitamin D (VD) and leukocyte telomere length (LTL). Telomeres shorten with age and are linked to chronic disease, while VD may influence this process through effects on inflammation and oxidative stress. Clarifying...
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2026
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| author | Clínica Dávila, Santiago, Chile Estefó Aroztegui, Magdalena Zúñiga, Valeria Andrea Instituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico González, Bárbara C. Canto Campillo, Delza Spencer de Vasconcellos, Leonardo Lick Gonçalves, Shaiana Carmignani Verdade, Roberto Gómez-Jaramillo, Ana María Pontificia Universidad Católica del Ecuador, Centro de Investigación para la Salud en América Latina (CISeAL) Rojas Humpire, Ricardo Josue Rocha Vaughan, Renata Ayala, Marcela Instituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico Khalil, Sally Alonso, Angie Njokanma, Azuka Spencer de Vasconcellos, Leonardo Polanco, Gustavo Araya, Guisella Clínica Alemana, Santiago, Chile Jaamour, Ghazal Fernandes, Renato de Souza Machado, Tiago Sarakool, Krittamuk Maqbool, Moeez Ireland, Health Service Executive Shahid, Samreen Aguilar, Thelma Clínica Dávila, Santiago, Chile Rodriguez, Fabiana Vieira Neves, Vinicius |
| author_browse | Aguilar, Thelma Alonso, Angie Araya, Guisella Ayala, Marcela Canto Campillo, Delza Carmignani Verdade, Roberto Clínica Alemana, Santiago, Chile Clínica Dávila, Santiago, Chile Estefó Aroztegui, Magdalena Fernandes, Renato González, Bárbara C. Gómez-Jaramillo, Ana María Instituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico Ireland, Health Service Executive Jaamour, Ghazal Khalil, Sally Lick Gonçalves, Shaiana Maqbool, Moeez Njokanma, Azuka Polanco, Gustavo Pontificia Universidad Católica del Ecuador, Centro de Investigación para la Salud en América Latina (CISeAL) Rocha Vaughan, Renata Rodriguez, Fabiana Rojas Humpire, Ricardo Josue Sarakool, Krittamuk Shahid, Samreen Spencer de Vasconcellos, Leonardo Vieira Neves, Vinicius Zúñiga, Valeria Andrea de Souza Machado, Tiago |
| author_facet | Clínica Dávila, Santiago, Chile Estefó Aroztegui, Magdalena Zúñiga, Valeria Andrea Instituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico González, Bárbara C. Canto Campillo, Delza Spencer de Vasconcellos, Leonardo Lick Gonçalves, Shaiana Carmignani Verdade, Roberto Gómez-Jaramillo, Ana María Pontificia Universidad Católica del Ecuador, Centro de Investigación para la Salud en América Latina (CISeAL) Rojas Humpire, Ricardo Josue Rocha Vaughan, Renata Ayala, Marcela Instituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico Khalil, Sally Alonso, Angie Njokanma, Azuka Spencer de Vasconcellos, Leonardo Polanco, Gustavo Araya, Guisella Clínica Alemana, Santiago, Chile Jaamour, Ghazal Fernandes, Renato de Souza Machado, Tiago Sarakool, Krittamuk Maqbool, Moeez Ireland, Health Service Executive Shahid, Samreen Aguilar, Thelma Clínica Dávila, Santiago, Chile Rodriguez, Fabiana Vieira Neves, Vinicius |
| author_sort | Clínica Dávila, Santiago, Chile |
| collection | Producción científica |
| description | Introduction: Interest in biological markers of healthy aging has grown, particularly vitamin D (VD) and leukocyte telomere length (LTL). Telomeres shorten with age and are linked to chronic disease, while VD may influence this process through effects on inflammation and oxidative stress. Clarifying the VD–LTL relationship could inform their value as biomarkers of longevity. Methods: A PRISMA-guided systematic review of observational studies was conducted, searching PubMed, EMBASE, Cochrane Library, and Scopus in April 2025. Eligible studies enrolled adults and reported serum/plasma VD and LTL measured with validated techniques. Risk of bias was appraised using the Newcastle–Ottawa Scale. Results: From 521 records, 32 full texts were assessed, and 11 observational studies were included (10 cross-sectional, 1 cohort) spanning Europe, the Americas, and Asia (2007–2023). VD was measured via CLIA/RIA, ELISA, or LC-MS/MS; LTL predominantly by qPCR (one Southern blot). Findings were heterogeneous: 4 studies reported longer LTL with higher 25-hydroxyvitamin D [25(OH)D], 1 showed a U-shaped association (shorter LTL at very low and very high 25(OH)D), and 6 found no significant relationship. Positive signals appeared more often in female or middle-aged subgroups, but variability in exposure/outcome definitions and covariate adjustment limited comparability and precluded meta-analysis. Risk of bias was generally low-to-moderate (2 “very good,” 8 “good,” 1 “unsatisfactory” on NOS). Discussion: Findings varied across studies. While some studies reported positive associations between vitamin D levels and telomere length—particularly in female and middle-aged populations—the majority found no significant relationship, and one study reported a U-shaped association. Substantial methodological heterogeneity in study design, vitamin D measurement methods, and covariate adjustment limits the ability to draw definitive conclusions. Based on current evidence, vitamin D supplementation cannot be recommended solely for telomere preservation, though the observed associations in specific subgroups warrant further investigation through well-designed longitudinal and interventional studies. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/550 |
| institution | UPeU |
| language | English |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/5502026-11-02T22:00:04ZLeukocyte Telomere Length and Vitamin D: A Systematic Review of Observational ResearchClínica Dávila, Santiago, ChileEstefó Aroztegui, MagdalenaZúñiga, Valeria AndreaInstituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, MexicoGonzález, Bárbara C.Canto Campillo, DelzaSpencer de Vasconcellos, LeonardoLick Gonçalves, ShaianaCarmignani Verdade, RobertoGómez-Jaramillo, Ana MaríaPontificia Universidad Católica del Ecuador, Centro de Investigación para la Salud en América Latina (CISeAL)Rojas Humpire, Ricardo JosueRocha Vaughan, RenataAyala, MarcelaInstituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, MexicoKhalil, SallyAlonso, AngieNjokanma, AzukaSpencer de Vasconcellos, LeonardoPolanco, GustavoAraya, GuisellaClínica Alemana, Santiago, ChileJaamour, GhazalFernandes, Renatode Souza Machado, TiagoSarakool, KrittamukMaqbool, MoeezIreland, Health Service ExecutiveShahid, SamreenAguilar, ThelmaClínica Dávila, Santiago, ChileRodriguez, FabianaVieira Neves, ViniciusIntroduction: Interest in biological markers of healthy aging has grown, particularly vitamin D (VD) and leukocyte telomere length (LTL). Telomeres shorten with age and are linked to chronic disease, while VD may influence this process through effects on inflammation and oxidative stress. Clarifying the VD–LTL relationship could inform their value as biomarkers of longevity. Methods: A PRISMA-guided systematic review of observational studies was conducted, searching PubMed, EMBASE, Cochrane Library, and Scopus in April 2025. Eligible studies enrolled adults and reported serum/plasma VD and LTL measured with validated techniques. Risk of bias was appraised using the Newcastle–Ottawa Scale. Results: From 521 records, 32 full texts were assessed, and 11 observational studies were included (10 cross-sectional, 1 cohort) spanning Europe, the Americas, and Asia (2007–2023). VD was measured via CLIA/RIA, ELISA, or LC-MS/MS; LTL predominantly by qPCR (one Southern blot). Findings were heterogeneous: 4 studies reported longer LTL with higher 25-hydroxyvitamin D [25(OH)D], 1 showed a U-shaped association (shorter LTL at very low and very high 25(OH)D), and 6 found no significant relationship. Positive signals appeared more often in female or middle-aged subgroups, but variability in exposure/outcome definitions and covariate adjustment limited comparability and precluded meta-analysis. Risk of bias was generally low-to-moderate (2 “very good,” 8 “good,” 1 “unsatisfactory” on NOS). Discussion: Findings varied across studies. While some studies reported positive associations between vitamin D levels and telomere length—particularly in female and middle-aged populations—the majority found no significant relationship, and one study reported a U-shaped association. Substantial methodological heterogeneity in study design, vitamin D measurement methods, and covariate adjustment limits the ability to draw definitive conclusions. Based on current evidence, vitamin D supplementation cannot be recommended solely for telomere preservation, though the observed associations in specific subgroups warrant further investigation through well-designed longitudinal and interventional studies.Articlehttps://doi.org/10.21801/ppcrj.2025.113.310.21801/ppcrj.2025.113.3https://hdl.handle.net/20.500.15037/550W7117887217enPrinciples and Practice of Clinical Research Journal2378-18902026-01-012026-06-13T08:17:03Z2026-06-13T08:17:03Z |
| spellingShingle | Clínica Dávila, Santiago, Chile Estefó Aroztegui, Magdalena Zúñiga, Valeria Andrea Instituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico González, Bárbara C. Canto Campillo, Delza Spencer de Vasconcellos, Leonardo Lick Gonçalves, Shaiana Carmignani Verdade, Roberto Gómez-Jaramillo, Ana María Pontificia Universidad Católica del Ecuador, Centro de Investigación para la Salud en América Latina (CISeAL) Rojas Humpire, Ricardo Josue Rocha Vaughan, Renata Ayala, Marcela Instituto Tecnológico y de Estudios Superiores de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico Khalil, Sally Alonso, Angie Njokanma, Azuka Spencer de Vasconcellos, Leonardo Polanco, Gustavo Araya, Guisella Clínica Alemana, Santiago, Chile Jaamour, Ghazal Fernandes, Renato de Souza Machado, Tiago Sarakool, Krittamuk Maqbool, Moeez Ireland, Health Service Executive Shahid, Samreen Aguilar, Thelma Clínica Dávila, Santiago, Chile Rodriguez, Fabiana Vieira Neves, Vinicius Leukocyte Telomere Length and Vitamin D: A Systematic Review of Observational Research |
| title | Leukocyte Telomere Length and Vitamin D: A Systematic Review of Observational Research |
| title_full | Leukocyte Telomere Length and Vitamin D: A Systematic Review of Observational Research |
| title_fullStr | Leukocyte Telomere Length and Vitamin D: A Systematic Review of Observational Research |
| title_full_unstemmed | Leukocyte Telomere Length and Vitamin D: A Systematic Review of Observational Research |
| title_short | Leukocyte Telomere Length and Vitamin D: A Systematic Review of Observational Research |
| title_sort | leukocyte telomere length and vitamin d a systematic review of observational research |
| url | https://doi.org/10.21801/ppcrj.2025.113.3 https://hdl.handle.net/20.500.15037/550 |
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