EVOLUTION OF THE PREVALENCE AND ANTIMICROBIAL RESISTANCE AMONG Escherichia coli ISOLATED AS A CAUSE OF INFECTION IN PATIENTS ADMITTED TO A IV-LEVEL HOSPITAL IN LIMA, PERU
The levels and evolution of antimicrobial resistance of Escherichia coli during 01/2009-06/2010 (Period 1), 01/2012-06-2013 (Period 2) and 07/2013-12/2014 (Period 3) were analyzed. Identification, susceptibility levels to 13 antibiotics and the presence of extendedspectrum β-lactamases (ESBLs) were...
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Brazilian Society of Parasitology
2022
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| author | Flores-Paredes, Wilfredo Luque Chipana, Nestor Alejandro Albornoz Toyohama, Roger Hiroshi Rojas, Nayade Espinoza, Manuel Ruiz, Joaquim Pons, María Jesus |
| author_browse | Albornoz Toyohama, Roger Hiroshi Espinoza, Manuel Flores-Paredes, Wilfredo Luque Chipana, Nestor Alejandro Pons, María Jesus Rojas, Nayade Ruiz, Joaquim |
| author_facet | Flores-Paredes, Wilfredo Luque Chipana, Nestor Alejandro Albornoz Toyohama, Roger Hiroshi Rojas, Nayade Espinoza, Manuel Ruiz, Joaquim Pons, María Jesus |
| author_sort | Flores-Paredes, Wilfredo |
| collection | Producción científica |
| description | The levels and evolution of antimicrobial resistance of Escherichia coli during 01/2009-06/2010 (Period 1), 01/2012-06-2013 (Period 2) and 07/2013-12/2014 (Period 3) were analyzed. Identification, susceptibility levels to 13 antibiotics and the presence of extendedspectrum β-lactamases (ESBLs) were determined. Overall, 9,918 microorganisms were isolated as a cause of infection. Of these 3,016 (30.4%) were E. coli, with 1,770 (59%), 992 (33%) and 254 (8%), from the Medicine and the Surgery Departments and the Intensive Care Unit (ICU), respectively. There was a significant increase (p=0.0002) of E. coli throughout considered periods. The isolates presented high levels of resistance (>60%) to cephalosporins, ciprofloxacin and cotrimoxazole, being only susceptible to imipenem (0.3% of resistance) and tigecycline. Overall the analysis of evolution of antimicrobial resistance showed that resistance to cephalosporins and amikacin significantly increased, while, the ones of piperacillintazobactam, cotrimoxazole and gentamicin had significantly decreased. Nevertheless, the ICU isolates showed an inverse scenario for cephalosporins. These findings agree with an increase of ESBLs on the Medicine (56% to 66%; p<0.0001) and on the Surgery (54% to 62%; p=0.0197) departments, with a parallel decrease in the ICU (76% to 68%). In summary, high levels of antimicrobial resistance have been reported among E. coli, with worrisome levels of ESBL. A continuous surveillance of antimicrobial resistance levels in the area is needed. KEY WORDS: Escherichia coli; antimicrobial resistance; cephalosporins |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/3101 |
| institution | UPeU |
| language | English |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Brazilian Society of Parasitology |
| publisherStr | Brazilian Society of Parasitology |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/31012026-11-02T22:00:04ZEVOLUTION OF THE PREVALENCE AND ANTIMICROBIAL RESISTANCE AMONG Escherichia coli ISOLATED AS A CAUSE OF INFECTION IN PATIENTS ADMITTED TO A IV-LEVEL HOSPITAL IN LIMA, PERUFlores-Paredes, WilfredoLuque Chipana, Nestor AlejandroAlbornoz Toyohama, Roger HiroshiRojas, NayadeEspinoza, ManuelRuiz, JoaquimPons, María JesusThe levels and evolution of antimicrobial resistance of Escherichia coli during 01/2009-06/2010 (Period 1), 01/2012-06-2013 (Period 2) and 07/2013-12/2014 (Period 3) were analyzed. Identification, susceptibility levels to 13 antibiotics and the presence of extendedspectrum β-lactamases (ESBLs) were determined. Overall, 9,918 microorganisms were isolated as a cause of infection. Of these 3,016 (30.4%) were E. coli, with 1,770 (59%), 992 (33%) and 254 (8%), from the Medicine and the Surgery Departments and the Intensive Care Unit (ICU), respectively. There was a significant increase (p=0.0002) of E. coli throughout considered periods. The isolates presented high levels of resistance (>60%) to cephalosporins, ciprofloxacin and cotrimoxazole, being only susceptible to imipenem (0.3% of resistance) and tigecycline. Overall the analysis of evolution of antimicrobial resistance showed that resistance to cephalosporins and amikacin significantly increased, while, the ones of piperacillintazobactam, cotrimoxazole and gentamicin had significantly decreased. Nevertheless, the ICU isolates showed an inverse scenario for cephalosporins. These findings agree with an increase of ESBLs on the Medicine (56% to 66%; p<0.0001) and on the Surgery (54% to 62%; p=0.0197) departments, with a parallel decrease in the ICU (76% to 68%). In summary, high levels of antimicrobial resistance have been reported among E. coli, with worrisome levels of ESBL. A continuous surveillance of antimicrobial resistance levels in the area is needed. KEY WORDS: Escherichia coli; antimicrobial resistance; cephalosporinsWe thank Donna Pringle for the language correction. Funding: JR was supported by Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT - Perú) and Universidad Científica del Sur within the “Proyecto de Mejoramiento y Ampliación de los Servicios del Sistema Nacional de Ciencia, Tecnología e Innovación Tecnológica” [contract: 08-2019-FONDECYT-BM-INC-INV”].Article10.5216/rpt.v51i3.743602-s2.0-85143387699https://hdl.handle.net/20.500.15037/3101enRevista de Patologia Tropical / Journal of Tropical PathologyJournal of Tropical Pathology0301-040608-2019-FONDECYT08-2019-FONDECYTBrazilian Society of Parasitology2022-10-192026-06-27T02:35:51Z2026-06-27T02:35:51Z |
| spellingShingle | Flores-Paredes, Wilfredo Luque Chipana, Nestor Alejandro Albornoz Toyohama, Roger Hiroshi Rojas, Nayade Espinoza, Manuel Ruiz, Joaquim Pons, María Jesus EVOLUTION OF THE PREVALENCE AND ANTIMICROBIAL RESISTANCE AMONG Escherichia coli ISOLATED AS A CAUSE OF INFECTION IN PATIENTS ADMITTED TO A IV-LEVEL HOSPITAL IN LIMA, PERU |
| title | EVOLUTION OF THE PREVALENCE AND ANTIMICROBIAL RESISTANCE AMONG Escherichia coli ISOLATED AS A CAUSE OF INFECTION IN PATIENTS ADMITTED TO A IV-LEVEL HOSPITAL IN LIMA, PERU |
| title_full | EVOLUTION OF THE PREVALENCE AND ANTIMICROBIAL RESISTANCE AMONG Escherichia coli ISOLATED AS A CAUSE OF INFECTION IN PATIENTS ADMITTED TO A IV-LEVEL HOSPITAL IN LIMA, PERU |
| title_fullStr | EVOLUTION OF THE PREVALENCE AND ANTIMICROBIAL RESISTANCE AMONG Escherichia coli ISOLATED AS A CAUSE OF INFECTION IN PATIENTS ADMITTED TO A IV-LEVEL HOSPITAL IN LIMA, PERU |
| title_full_unstemmed | EVOLUTION OF THE PREVALENCE AND ANTIMICROBIAL RESISTANCE AMONG Escherichia coli ISOLATED AS A CAUSE OF INFECTION IN PATIENTS ADMITTED TO A IV-LEVEL HOSPITAL IN LIMA, PERU |
| title_short | EVOLUTION OF THE PREVALENCE AND ANTIMICROBIAL RESISTANCE AMONG Escherichia coli ISOLATED AS A CAUSE OF INFECTION IN PATIENTS ADMITTED TO A IV-LEVEL HOSPITAL IN LIMA, PERU |
| title_sort | evolution of the prevalence and antimicrobial resistance among escherichia coli isolated as a cause of infection in patients admitted to a iv level hospital in lima peru |
| url | https://hdl.handle.net/20.500.15037/3101 |
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