blaOXA−51-Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in Peru
Background Common identification techniques do not differentiate among members of the Acinetobacter calcoaceticus–baumannii (ACB) complex, and the presence of non‐ baumannii Acinetobacter is often misinterpreted. The blaOXA−51 gene is located within the chromosome of Acinetobacter baumannii . Despit...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
John Wiley and Sons Ltd
2025
|
| Materias: | |
| Acceso en línea: | Enlace permanente (DOI o Handle) |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1881508882329632768 |
|---|---|
| author | Oporto-Llerena, Rosario Huerto-Huanuco, Rosario Quispe-Hualpa, Yaneth Palomino-Kobayashi, Luciano A. Soza, Gabriela Rojas-Jaimes, Jesús Eduardo Gonzales, Patricia Pollack, Luis Gomez, Andrea C. Salvador-Luján, Gina Cuaresma, Edwin Luque Chipana, Nestor Alejandro Casapia, Martin Arteaga-Livias, Kovy Sáenz, Yolanda Pons, María Jesus Ruiz, Joaquim |
| author_browse | Arteaga-Livias, Kovy Casapia, Martin Cuaresma, Edwin Gomez, Andrea C. Gonzales, Patricia Huerto-Huanuco, Rosario Luque Chipana, Nestor Alejandro Oporto-Llerena, Rosario Palomino-Kobayashi, Luciano A. Pollack, Luis Pons, María Jesus Quispe-Hualpa, Yaneth Rojas-Jaimes, Jesús Eduardo Ruiz, Joaquim Salvador-Luján, Gina Soza, Gabriela Sáenz, Yolanda |
| author_facet | Oporto-Llerena, Rosario Huerto-Huanuco, Rosario Quispe-Hualpa, Yaneth Palomino-Kobayashi, Luciano A. Soza, Gabriela Rojas-Jaimes, Jesús Eduardo Gonzales, Patricia Pollack, Luis Gomez, Andrea C. Salvador-Luján, Gina Cuaresma, Edwin Luque Chipana, Nestor Alejandro Casapia, Martin Arteaga-Livias, Kovy Sáenz, Yolanda Pons, María Jesus Ruiz, Joaquim |
| author_sort | Oporto-Llerena, Rosario |
| collection | Producción científica |
| description | Background Common identification techniques do not differentiate among members of the Acinetobacter calcoaceticus–baumannii (ACB) complex, and the presence of non‐ baumannii Acinetobacter is often misinterpreted. The blaOXA−51 gene is located within the chromosome of Acinetobacter baumannii . Despite its plasmid dissemination to other members of the genus, it may be considered in initial species screening. Thus, this study aimed to determine the presence of blaOXA−51 ‐negative Acinetobacter spp. as a cause of infection in Peru. Methods Two hundred ninety‐eight ACB complex isolates from different regions of Peru were isolated between January 2018 and March 2024. Of these, 272 and 25 were confirmed as hospital‐acquired and community infections, respectively. The presence of blaOXA−51 was determined by polymerase chain reaction, and the susceptibility levels to 12 antimicrobial agents were determined. Results The results showed that 38 (12.7%) isolates were blaOXA−51 ‐negative. These isolates were frequent among community infections (13/25, p < 0.0001), often causing urine infections. They showed significantly lower levels of resistance to almost all antimicrobial agents tested, and most of them were recovered from regions outside metropolitan Lima. Conclusion A relevant number of infections by non‐ baumannii Acinetobacter species in Peru is suggested, highlighting the need for systematic identification of these species in the country. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/2880 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | John Wiley and Sons Ltd |
| publisherStr | John Wiley and Sons Ltd |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/28802026-11-03T23:05:08ZblaOXA−51-Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in PeruOporto-Llerena, RosarioHuerto-Huanuco, RosarioQuispe-Hualpa, YanethPalomino-Kobayashi, Luciano A.Soza, GabrielaRojas-Jaimes, Jesús EduardoGonzales, PatriciaPollack, LuisGomez, Andrea C.Salvador-Luján, GinaCuaresma, EdwinLuque Chipana, Nestor AlejandroCasapia, MartinArteaga-Livias, KovySáenz, YolandaPons, María JesusRuiz, JoaquimAntibiotic ResistanceAcinetobacter SppHospital-acquired InfectionCommunity-acquired InfectionOxa-51Background Common identification techniques do not differentiate among members of the Acinetobacter calcoaceticus–baumannii (ACB) complex, and the presence of non‐ baumannii Acinetobacter is often misinterpreted. The blaOXA−51 gene is located within the chromosome of Acinetobacter baumannii . Despite its plasmid dissemination to other members of the genus, it may be considered in initial species screening. Thus, this study aimed to determine the presence of blaOXA−51 ‐negative Acinetobacter spp. as a cause of infection in Peru. Methods Two hundred ninety‐eight ACB complex isolates from different regions of Peru were isolated between January 2018 and March 2024. Of these, 272 and 25 were confirmed as hospital‐acquired and community infections, respectively. The presence of blaOXA−51 was determined by polymerase chain reaction, and the susceptibility levels to 12 antimicrobial agents were determined. Results The results showed that 38 (12.7%) isolates were blaOXA−51 ‐negative. These isolates were frequent among community infections (13/25, p < 0.0001), often causing urine infections. They showed significantly lower levels of resistance to almost all antimicrobial agents tested, and most of them were recovered from regions outside metropolitan Lima. Conclusion A relevant number of infections by non‐ baumannii Acinetobacter species in Peru is suggested, highlighting the need for systematic identification of these species in the country.Funding text 1: This study was supported by the Programa Nacional de Investigaci\u00F3n Cient\u00EDfica y Estudios Avanzados (PROCIENCIA, Peru) under the financial scheme \u201CE041-2023-001-Proyectos de Investigaci\u00F3n B\u00E1sica\u201D (contract: PE501082454-2023-PROCIENCIA) and Universidad Cient\u00EDfica del Sur (project 059-2023-PRO99), and developed within the frame of the net 221RT0113 from the Programa Iberoamericano\u200B de Ciencia y Tecnolog\u00EDa para el Desarrollo (CYTED). The authors would like to thank the Members of the Research Group on Peruvian Acinetobacter spp. (RPGA): Zulema Surichaqui-Cerr\u00F3n (Research Group on Dynamics and Epidemiology of Antimicrobial Resistance\u2014\u201COne Health,\u201D Universidad Cientifica del Sur, Lima, Per\u00FA; Microbiology Service, Instituto Nacional Materno Perinatal, Lima, Peru); Maria R. Chirinos (Microbiology Service, Instituto Nacional Materno Perinatal, Lima, Peru); Luis Casta\u00F1eda (Faculty of Health Sciences, Universidad Privada del Norte, Lima, Peru); Delza Tarraga Gonzales and Elsa Nu\u00F1ez Infanz\u00F3n (Microbiology Service, Hospital Nacional Guillermo Almenara Irigoyen, ESSALUD, Lima, Peru); Carmen Valera-Krumdieck (Clinical Pathology Service, Microbiology Area, Hospital Maria Auxiliadora, Lima, Peru); Katherine Alcedo and William Villegas Quispe (Laboratory of Microbiology, Hospital Nacional PNP Luis N. S\u00E1enz, Lima, Peru); Alejandra Vizcarra and Joseph Pinto (Center for Basic and TranslationaArticle10.1155/jotm/88519062-s2.0-105023409695https://hdl.handle.net/20.500.15037/2880enJournal of Tropical MedicineJournal of Tropical Medicine1687-9686PE501082454-2023PE501082454-2023John Wiley and Sons Ltd2025-01-012026-06-27T02:34:29Z2026-06-27T02:34:29Z |
| spellingShingle | Antibiotic Resistance Acinetobacter Spp Hospital-acquired Infection Community-acquired Infection Oxa-51 Oporto-Llerena, Rosario Huerto-Huanuco, Rosario Quispe-Hualpa, Yaneth Palomino-Kobayashi, Luciano A. Soza, Gabriela Rojas-Jaimes, Jesús Eduardo Gonzales, Patricia Pollack, Luis Gomez, Andrea C. Salvador-Luján, Gina Cuaresma, Edwin Luque Chipana, Nestor Alejandro Casapia, Martin Arteaga-Livias, Kovy Sáenz, Yolanda Pons, María Jesus Ruiz, Joaquim blaOXA−51-Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in Peru |
| title | blaOXA−51-Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in Peru |
| title_full | blaOXA−51-Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in Peru |
| title_fullStr | blaOXA−51-Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in Peru |
| title_full_unstemmed | blaOXA−51-Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in Peru |
| title_short | blaOXA−51-Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in Peru |
| title_sort | blaoxa 51 negative acinetobacter calcoaceticus baumannii complex as a cause of human infection in peru |
| topic | Antibiotic Resistance Acinetobacter Spp Hospital-acquired Infection Community-acquired Infection Oxa-51 |
| topic_facet | Antibiotic Resistance Acinetobacter Spp Hospital-acquired Infection Community-acquired Infection Oxa-51 |
| url | https://hdl.handle.net/20.500.15037/2880 |
| work_keys_str_mv | AT oportollerenarosario blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT huertohuanucorosario blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT quispehualpayaneth blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT palominokobayashilucianoa blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT sozagabriela blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT rojasjaimesjesuseduardo blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT gonzalespatricia blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT pollackluis blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT gomezandreac blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT salvadorlujangina blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT cuaresmaedwin blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT luquechipananestoralejandro blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT casapiamartin blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT arteagaliviaskovy blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT saenzyolanda blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT ponsmariajesus blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu AT ruizjoaquim blaoxa51negativeacinetobactercalcoaceticusbaumanniicomplexasacauseofhumaninfectioninperu |