Dynamic immune markers predict HIV acquisition and augment associations with sociobehavioral factors for HIV exposure
study in Peru, and assessed a panel of plasma immune biomarkers at enrollment and longitudinally, including within a month of diagnosis of primary HIV or matched timepoint in controls. We used machine learning to select biomarkers and sociobehavioral covariates predictive of HIV acquisition. Most bi...
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| Formato: | Artículo |
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2022
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| _version_ | 1881508873157738496 |
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| author | Rachel Bender Ignacio Sayan Dasgupta Rogelio Valdez Urvashi Pandey Siavash Pasalar Ricardo Alfaro Florian Hladik Germán G. Gornalusse Javier R. Lama Ann Duerr |
| author_browse | Ann Duerr Florian Hladik Germán G. Gornalusse Javier R. Lama Rachel Bender Ignacio Ricardo Alfaro Rogelio Valdez Sayan Dasgupta Siavash Pasalar Urvashi Pandey |
| author_facet | Rachel Bender Ignacio Sayan Dasgupta Rogelio Valdez Urvashi Pandey Siavash Pasalar Ricardo Alfaro Florian Hladik Germán G. Gornalusse Javier R. Lama Ann Duerr |
| author_sort | Rachel Bender Ignacio |
| collection | Producción científica |
| description | study in Peru, and assessed a panel of plasma immune biomarkers at enrollment and longitudinally, including within a month of diagnosis of primary HIV or matched timepoint in controls. We used machine learning to select biomarkers and sociobehavioral covariates predictive of HIV acquisition. Most biomarkers were indistinguishable between cases and controls one month before HIV diagnosis. However, levels differed between cases and controls at study entry, months to years earlier. Dynamic changes in IL-2, IL-7, IL-10, IP-10 and IL-12, rather than absolute levels, jointly predicted HIV risk when added to traditional risk factors, and there was modest effect modification of biomarkers on association between sociobehavioral risk factors and HIV acquisition. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1760 |
| institution | UPeU |
| language | English |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/17602026-10-30T16:16:42ZDynamic immune markers predict HIV acquisition and augment associations with sociobehavioral factors for HIV exposureRachel Bender IgnacioSayan DasguptaRogelio ValdezUrvashi PandeySiavash PasalarRicardo AlfaroFlorian HladikGermán G. GornalusseJavier R. LamaAnn DuerrHuman immunodeficiency virus (HIV)Immune systemImmunologyCase-control studyMedicineAssociation (psychology)PsychologyInternal medicinePsychotherapistHuman immunodeficiency virus (HIV)Immune systemImmunologyCase-control studyMedicineAssociation (psychology)PsychologyInternal medicineLife Sciences Immunology and Microbiology Virology HIV Research and TreatmentHealth Sciences Medicine Infectious Diseases HIV/AIDS Research and InterventionsHealth Sciences Health Professions General Health Professions Adolescent Sexual and Reproductive Healthstudy in Peru, and assessed a panel of plasma immune biomarkers at enrollment and longitudinally, including within a month of diagnosis of primary HIV or matched timepoint in controls. We used machine learning to select biomarkers and sociobehavioral covariates predictive of HIV acquisition. Most biomarkers were indistinguishable between cases and controls one month before HIV diagnosis. However, levels differed between cases and controls at study entry, months to years earlier. Dynamic changes in IL-2, IL-7, IL-10, IP-10 and IL-12, rather than absolute levels, jointly predicted HIV risk when added to traditional risk factors, and there was modest effect modification of biomarkers on association between sociobehavioral risk factors and HIV acquisition.Articlehttps://pubmed.ncbi.nlm.nih.gov/36483014https://doi.org/10.1016/j.isci.2022.10563210.1016/j.isci.2022.105632https://hdl.handle.net/20.500.15037/1760W4309726475eniScience2589-00422022-11-192026-06-13T14:21:40Z2026-06-13T14:21:40Z |
| spellingShingle | Human immunodeficiency virus (HIV) Immune system Immunology Case-control study Medicine Association (psychology) Psychology Internal medicine Psychotherapist Human immunodeficiency virus (HIV) Immune system Immunology Case-control study Medicine Association (psychology) Psychology Internal medicine Life Sciences Immunology and Microbiology Virology HIV Research and Treatment Health Sciences Medicine Infectious Diseases HIV/AIDS Research and Interventions Health Sciences Health Professions General Health Professions Adolescent Sexual and Reproductive Health Rachel Bender Ignacio Sayan Dasgupta Rogelio Valdez Urvashi Pandey Siavash Pasalar Ricardo Alfaro Florian Hladik Germán G. Gornalusse Javier R. Lama Ann Duerr Dynamic immune markers predict HIV acquisition and augment associations with sociobehavioral factors for HIV exposure |
| title | Dynamic immune markers predict HIV acquisition and augment associations with sociobehavioral factors for HIV exposure |
| title_full | Dynamic immune markers predict HIV acquisition and augment associations with sociobehavioral factors for HIV exposure |
| title_fullStr | Dynamic immune markers predict HIV acquisition and augment associations with sociobehavioral factors for HIV exposure |
| title_full_unstemmed | Dynamic immune markers predict HIV acquisition and augment associations with sociobehavioral factors for HIV exposure |
| title_short | Dynamic immune markers predict HIV acquisition and augment associations with sociobehavioral factors for HIV exposure |
| title_sort | dynamic immune markers predict hiv acquisition and augment associations with sociobehavioral factors for hiv exposure |
| topic | Human immunodeficiency virus (HIV) Immune system Immunology Case-control study Medicine Association (psychology) Psychology Internal medicine Psychotherapist Human immunodeficiency virus (HIV) Immune system Immunology Case-control study Medicine Association (psychology) Psychology Internal medicine Life Sciences Immunology and Microbiology Virology HIV Research and Treatment Health Sciences Medicine Infectious Diseases HIV/AIDS Research and Interventions Health Sciences Health Professions General Health Professions Adolescent Sexual and Reproductive Health |
| topic_facet | Human immunodeficiency virus (HIV) Immune system Immunology Case-control study Medicine Association (psychology) Psychology Internal medicine Psychotherapist Human immunodeficiency virus (HIV) Immune system Immunology Case-control study Medicine Association (psychology) Psychology Internal medicine Life Sciences Immunology and Microbiology Virology HIV Research and Treatment Health Sciences Medicine Infectious Diseases HIV/AIDS Research and Interventions Health Sciences Health Professions General Health Professions Adolescent Sexual and Reproductive Health |
| url | https://pubmed.ncbi.nlm.nih.gov/36483014 https://doi.org/10.1016/j.isci.2022.105632 https://hdl.handle.net/20.500.15037/1760 |
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